GABPB2 - GA binding protein transcription factor subunit beta 2 Gene

Homo sapiens

Also known as GABPB-2

Gene ID: 126626 | Gene type: protein coding

About GABPB2

This gene has 6 transcripts (splice variants), 160 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 4.7), ovary (RPKM 3.2) and 25 other tissues.

Summary

Enables transcription cis-regulatory region binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

GABPB2 Products(9)

mRNA	Protein	Name
NM_001323906.2	NP_001310835.1	GA-binding protein subunit beta-2 isoform b
NM_001323907.2	NP_001310836.1	GA-binding protein subunit beta-2 isoform c
NM_001323908.2	NP_001310837.1	GA-binding protein subunit beta-2 isoform a
NM_001323909.2	NP_001310838.1	GA-binding protein subunit beta-2 isoform d
NM_001323910.2	NP_001310839.1	GA-binding protein subunit beta-2 isoform h
NM_001323911.2	NP_001310840.1	GA-binding protein subunit beta-2 isoform e
NM_001323912.2	NP_001310841.1	GA-binding protein subunit beta-2 isoform f
NM_001323913.2	NP_001310842.1	GA-binding protein subunit beta-2 isoform g
NM_144618.3	NP_653219.1	GA-binding protein subunit beta-2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	9857059	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9857059	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	9857059	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GABPB2 Protein Structure

Ank_3

Ank_2

0
100
200
300
400
448 a.a.

Protein Preferred Names

Protein Names

GA-binding protein subunit beta-2

GA binding protein transcription factor beta subunit 2

GABPB2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GABPB2	Q8TAK5	VAC14	Homo sapiens	Q08AM6	Y2H Array	32296183
Intra	GABPB2	Q8TAK5	VAC14	Homo sapiens	Q08AM6	Y2H Prey Pooling	32296183
Intra	GABPB2	Q8TAK5	LONRF1	Homo sapiens	Q17RB8	Y2H Array	32296183
Intra	GABPB2	Q8TAK5	LONRF1	Homo sapiens	Q17RB8	Y2H Prey Pooling	32296183
Intra	GABPB2	Q8TAK5	GABPA	Homo sapiens	Q06546	Anti Tag CoIP	33961781
Intra	GABPB2	Q8TAK5	GABPA	Homo sapiens	Q06546	Y2H Prey Pooling	32296183
Intra	GABPB2	Q8TAK5	GABPA	Homo sapiens	Q06546	Anti Tag CoIP	28514442
Intra	GABPB2	Q8TAK5	GABPA	Homo sapiens	Q06546	Y2H Array	32296183
Intra	GABPB2	Q8TAK5	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	25416956
Intra	GABPB2	Q8TAK5	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	25416956
Intra	GABPB2	Q8TAK5	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
Intra	GABPB2	Q8TAK5	FLNA	Homo sapiens	P21333-2	Y2H Array	32814053
Intra	GABPB2	Q8TAK5	FLNA	Homo sapiens	P21333-2	Validated Y2H	32814053
Intra	GABPB2	Q8TAK5	FLNA	Homo sapiens	P21333-2	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Paranoid Schizophrenia

Chronic Paranoid Schizophrenia	Paranoid Type Schizophrenia
Paranoid Type Schizophrenia Subchronic State	Paraphrenia - Late
Paraphrenic Schizophrenia	Schizophrenia, Paranoid

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05208	GABPB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GABPB2	VGNC	VGNC:29190
Rattus norvegicus	GABPB2	RGD	RGD:1565234
Macaca mulatta	GABPB2	VGNC	VGNC:72798
Felis catus	GABPB2	VGNC	VGNC:80214
Mus musculus	GABPB2	MGD	MGI:95612
Canis familiaris	GABPB2	VGNC	VGNC:41052

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