2. Gene
  3. GABPA - GA binding protein transcription factor subunit alpha Gene

GABPA - GA binding protein transcription factor subunit alpha Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as NFT2; NRF2; NRF2A; E4TF1A; E4TF1-60; RCH04A07

Gene ID: 2551 | Gene type: protein coding

About GABPA

Cytogenetic location: 21q21.3 Genomic coordinates (GRCh38): 21:25,734,972-25,772,460 (from NCBI)

This gene has 3 transcripts (splice variants), 214 orthologues and 28 paralogues. Ubiquitous expression in thyroid (RPKM 13.9), endometrium (RPKM 11.3) and 25 other tissues.

Summary

This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with Other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2010]

GABPA Products(2)

mRNA Protein Name
NM_001197297.2 NP_001184226.1 GA-binding protein alpha chain
NM_002040.4 NP_002031.2 GA-binding protein alpha chain
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
12750007 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12750007 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10675337 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
9857059 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9857059 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12750007 GOA
Cellular Component GO Annotation Evidence Reference Source
located in chromatin IDA
IDA: Inferred from direct assay
22306510 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9857059 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GABPA Protein Structure

GABP-alpha

GABP-alpha: GA-binding protein alpha chain (35 - 122)

SAM_PNT

SAM_PNT: Sterile alpha motif (SAM)/Pointed domain (171 - 250)

Ets

Ets: Ets-domain (319 - 401)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 454 a.a.
Protein Preferred Names Protein Names

GA-binding protein alpha chain

GA binding protein transcription factor alpha subunit 60kDa

GABPA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
GABPA Q06546 ZC2HC1B Homo sapiens Q5TFG8
Y2H Array
32296183
Intra
GABPA Q06546 ZC2HC1B Homo sapiens Q5TFG8
Y2H Prey Pooling
32296183
Intra
GABPA Q06546 ZC2HC1B Homo sapiens Q5TFG8
Validated Y2H
32296183
Intra
GABPA Q06546 GABPB1 Homo sapiens Q06547
Anti Tag CoIP
33961781
Intra
GABPA Q06546 GABPB1 Homo sapiens Q06547
Validated Y2H
32296183
Intra
GABPA Q06546 STK16 Homo sapiens O75716
Y2H Array
32296183
Intra
GABPA Q06546 STK16 Homo sapiens O75716
Y2H Prey Pooling
32296183
Intra
GABPA Q06546 GABPB2 Homo sapiens Q8TAK5
Validated Y2H
32296183
Intra
GABPA Q06546 GABPB2 Homo sapiens Q8TAK5
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05206 GABPA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GABPA VGNC VGNC:41050
Mus musculus GABPA MGD MGI:95610
Rattus norvegicus GABPA RGD RGD:1310802
Bos taurus GABPA VGNC VGNC:29189
Macaca mulatta GABPA VGNC VGNC:72844
Felis catus GABPA VGNC VGNC:62416