2. Gene
  3. Clk1 - CDC-like kinase 1 Gene

Clk1 - CDC-like kinase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as STY

Gene ID: 12747 | Gene type: protein coding

About Clk1

Chromosome 1: 58,449,348-58,463,225 reverse strand.GRCm39:CM000994.3

This gene has 13 transcripts (splice variants), 185 orthologues, 12 paralogues and is associated with 17 phenotypes. Broad expression in bladder adult (RPKM 71.4), limb E14.5 (RPKM 59.9) and 23 other tissues.

Summary

Enables protein serine/threonine kinase activity and protein tyrosine kinase activity. Acts upstream of or within protein phosphorylation. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; liver; neural retina; and thyroid gland. Orthologous to human CLK1 (CDC like kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Clk1 Products(1)

mRNA Protein Name
NM_001042634.2 NP_001036099.1 dual specificity protein kinase CLK1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
18284575 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
1825055 MGI
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
1825055 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
1825055 MGI
acts upstream of or within peptidyl-threonine phosphorylation IDA
IDA: Inferred from direct assay
1986248 MGI
acts upstream of or within peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
1825055 MGI
acts upstream of or within protein autophosphorylation IDA
IDA: Inferred from direct assay
1825055 MGI
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
9307018 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Clk1 Protein Structure

PKc_CLK1_4

PKc_CLK1_4: cd14213 (146 - 475)

  • 0
  • 100
  • 200
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  • 400
  • 483 a.a.
Protein Preferred Names Protein Names

dual specificity protein kinase CLK1

protein kinase STY

Related Agents

Pre-clinical Phase
Bioactive Molecules (32)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15338 TG003 Inhibitor 99.57% Unkown
HY-115470 CLK-IN-T3 Inhibitor 98.63% Unkown
HY-112296 T025 98.84% Unkown
HY-15951 ML167 Inhibitor 98.62% Unkown
HY-103082 CLK1-IN-1 Inhibitor 98.79% Unkown
HY-12828 KH-CB19 Inhibitor 99.31% Unkown
HY-111379 EHT 5372 Inhibitor 98.12% Unkown
HY-152219 CLK1-IN-2 Inhibitor 98.73% Unkown
HY-103647 K00546 Inhibitor 98.08% Unkown
HY-117049 Leucettine L41 Inhibitor 98.70% Unkown
HY-123600 SRI-29329 Inhibitor 99.73% Unkown
HY-149262 CLK1-IN-3 98.03% Unkown
HY-12828A KH-CB20 Inhibitor 99.80% Unkown
HY-131978 DB18 Inhibitor 98.27% Unkown
HY-N12625 (R)-(+)-O-Demethylbuchenavianine Inhibitor 98.67% Unkown
HY-113825 CLK1/2-IN-1 Inhibitor 99.87% Unkown
HY-153708 SGC-CLK-1 Inhibitor / Unkown
HY-131909 CJ-2360 Inhibitor / Unkown
HY-113670 CLK1/2-IN-2 Inhibitor / Unkown
HY-113831 CLK1/2-IN-3 Inhibitor / Unkown
HY-125202 KuWal151 Inhibitor / Unkown
HY-146335 CLK1/4-IN-1 Inhibitor / Unkown
HY-146586 Haspin-IN-1 Inhibitor / Unkown
HY-146587 Haspin-IN-2 Inhibitor / Unkown
HY-15338A (E/Z)-TG003 Inhibitor / Unkown
HY-155723 Leucettinib-92 Inhibitor / Unkown
HY-157995 Dyrk1A-IN-7 Inhibitor / Unkown
HY-400528 CLK1-IN-4 Inhibitor 99.75% Unkown
HY-RS02814 CLK1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS02815 Clk1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS02816 Clk1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-122631 TG693 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Clk1 NCBI NCBI:1195