2. Cell Cycle/DNA Damage
  3. CDK
  4. CLK1-IN-2

CLK1-IN-2 is metabolically stable Clk1 inhibitor. CLK1-IN-2 has selectivity for Clk1 with an IC50 value of 1.7 nM. CLK1-IN-2 can be used for the research of tumour, Duchenne's muscular dystrophy and viral infections such as HIV-1 and influenza.

For research use only. We do not sell to patients.

CLK1-IN-2 Chemical Structure

CLK1-IN-2 Chemical Structure

CAS No. : 3029431-68-0

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Based on 1 publication(s) in Google Scholar

CLK1-IN-2 Related Antibodies

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Description

CLK1-IN-2 is metabolically stable Clk1 inhibitor. CLK1-IN-2 has selectivity for Clk1 with an IC50 value of 1.7 nM. CLK1-IN-2 can be used for the research of tumour, Duchenne's muscular dystrophy and viral infections such as HIV-1 and influenza[1].

IC50 & Target

IC50: 1.7 nM (Clk1)[1].
In Vitro

CLK1-IN-2 (Compound 27a) has selectivity for Clk1 with an IC50 value of 1.7 nM[1].
CLK1-IN-2 shows long metabolic half-lives of 6.4 h[1].
CLK1-IN-2exhibits a GI50 of 3.4 μM in T24 cancer cells[1].
CLK1-IN-2 shows a cellular Ki valiue of 0.051 μM in NanoBRET cellular Clk1 engagement assay[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CLK1-IN-2 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: Human dermal fibroblasts
Concentration: 15 μM
Incubation Time: 2 days
Result: Not affected the proliferation of normal human cells such as fibroblasts.
Molecular Weight

367.25

Formula

C16H12Cl2N2O2S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CC2=CC(OC)=CC=C2S1)NNC3=CC(Cl)=CC(Cl)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (272.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7229 mL 13.6147 mL 27.2294 mL
5 mM 0.5446 mL 2.7229 mL 5.4459 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7229 mL 13.6147 mL 27.2294 mL 68.0735 mL
5 mM 0.5446 mL 2.7229 mL 5.4459 mL 13.6147 mL
10 mM 0.2723 mL 1.3615 mL 2.7229 mL 6.8074 mL
15 mM 0.1815 mL 0.9076 mL 1.8153 mL 4.5382 mL
20 mM 0.1361 mL 0.6807 mL 1.3615 mL 3.4037 mL
25 mM 0.1089 mL 0.5446 mL 1.0892 mL 2.7229 mL
30 mM 0.0908 mL 0.4538 mL 0.9076 mL 2.2691 mL
40 mM 0.0681 mL 0.3404 mL 0.6807 mL 1.7018 mL
50 mM 0.0545 mL 0.2723 mL 0.5446 mL 1.3615 mL
60 mM 0.0454 mL 0.2269 mL 0.4538 mL 1.1346 mL
80 mM 0.0340 mL 0.1702 mL 0.3404 mL 0.8509 mL
100 mM 0.0272 mL 0.1361 mL 0.2723 mL 0.6807 mL
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CLK1-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CLK1-IN-23029431-68-0CDKCyclin dependent kinaseClk1selectivitytumourDuchenne's muscular dystrophyviral infectionsHIV-1influenzaInhibitorinhibitorinhibit

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