2. Gene
  3. CLK1 - CDC like kinase 1 Gene

CLK1 - CDC like kinase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as CLK; STY; CLK/STY

Gene ID: 1195 | Gene type: protein coding

About CLK1

Cytogenetic location: 2q33.1 Genomic coordinates (GRCh38): 2:200,853,009-200,864,658 (from NCBI)

This gene has 14 transcripts (splice variants), 185 orthologues and 12 paralogues. Ubiquitous expression in bone marrow (RPKM 96.5), lymph node (RPKM 51.9) and 25 other tissues.

Summary

This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

CLK1 Products(5)

mRNA Protein Name
NM_001162407.1 NP_001155879.1 dual specificity protein kinase CLK1 isoform 2
NM_004071.4 NP_004062.2 dual specificity protein kinase CLK1 isoform 1
NR_027856.2
NR_027855.2
NM_001024646.1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
10480872 GOA
Biological Process GO Annotation Evidence Reference Source
involved in regulation of RNA splicing IMP
IMP: Inferred from mutant phenotype
19168442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLK1 Protein Structure

Pkinase

Pkinase: Protein kinase domain (161 - 477)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 484 a.a.
Protein Preferred Names Protein Names

dual specificity protein kinase CLK1

CDC28/CDC2-like kinase

protein tyrosine kinase STY

CLK1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CLK1 P49759 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
25416956
Intra
CLK1 P49759 PDE9A Homo sapiens O76083
Validated Y2H
25416956
Intra
CLK1 P49759 PDE9A Homo sapiens O76083
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (32)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15338 TG003 Inhibitor 99.57% Unkown
HY-115470 CLK-IN-T3 Inhibitor 98.63% Unkown
HY-112296 T025 98.84% Unkown
HY-15951 ML167 Inhibitor 98.62% Unkown
HY-103082 CLK1-IN-1 Inhibitor 98.79% Unkown
HY-12828 KH-CB19 Inhibitor 99.31% Unkown
HY-111379 EHT 5372 Inhibitor 98.12% Unkown
HY-152219 CLK1-IN-2 Inhibitor 98.73% Unkown
HY-103647 K00546 Inhibitor 98.08% Unkown
HY-117049 Leucettine L41 Inhibitor 98.70% Unkown
HY-123600 SRI-29329 Inhibitor 99.73% Unkown
HY-149262 CLK1-IN-3 98.03% Unkown
HY-12828A KH-CB20 Inhibitor 99.80% Unkown
HY-131978 DB18 Inhibitor 98.27% Unkown
HY-N12625 (R)-(+)-O-Demethylbuchenavianine Inhibitor 98.67% Unkown
HY-113825 CLK1/2-IN-1 Inhibitor 99.87% Unkown
HY-153708 SGC-CLK-1 Inhibitor / Unkown
HY-131909 CJ-2360 Inhibitor / Unkown
HY-113670 CLK1/2-IN-2 Inhibitor / Unkown
HY-113831 CLK1/2-IN-3 Inhibitor / Unkown
HY-125202 KuWal151 Inhibitor / Unkown
HY-146335 CLK1/4-IN-1 Inhibitor / Unkown
HY-146586 Haspin-IN-1 Inhibitor / Unkown
HY-146587 Haspin-IN-2 Inhibitor / Unkown
HY-15338A (E/Z)-TG003 Inhibitor / Unkown
HY-155723 Leucettinib-92 Inhibitor / Unkown
HY-157995 Dyrk1A-IN-7 Inhibitor / Unkown
HY-400528 CLK1-IN-4 Inhibitor 99.75% Unkown
HY-RS02814 CLK1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS02815 Clk1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS02816 Clk1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-122631 TG693 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CLK1 MGD MGI:107403
Rattus norvegicus CLK1 RGD RGD:1311469
Felis catus CLK1 VGNC VGNC:60963
Bos taurus CLK1 VGNC VGNC:27448
Macaca mulatta CLK1 VGNC VGNC:71258
Canis familiaris CLK1 VGNC VGNC:39346
Others CLK1 NCBI