SELENOK - selenoprotein K Gene

Homo sapiens

Also known as SELK; HSPC030; HSPC297

Gene ID: 58515 | Gene type: protein coding

About SELENOK

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:53,884,417-53,891,859 (from NCBI)

This gene has 4 transcripts (splice variants) and 193 orthologues. Ubiquitous expression in adrenal (RPKM 48.3), thyroid (RPKM 43.1) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the selenoprotein K family. It is a transmembrane protein that is localized in the endoplasmic reticulum (ER), and is involved in ER-associated degradation (ERAD) of misfolded, glycosylated proteins. It also has a role in the protection of cells from ER stress-induced Apoptosis. Knockout studies in mice show the importance of this gene in promoting CA(2+) flux in immune cells and mounting effective immune response. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Pseudogenes of this locus have been identified on chromosomes 6 and 19.[provided by RefSeq, Aug 2017]

SELENOK Products(1)

mRNA	Protein	Name
NM_021237.5	NP_067060.2	selenoprotein K

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25117454	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25368151	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	20692228	GOA
involved in protein palmitoylation	IDA IDA: Inferred from direct assay	25368151	GOA
involved in response to oxidative stress	IMP IMP: Inferred from mutant phenotype	16962588	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	16962588	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	21220695	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SELENOK Protein Structure

SelK_SelG

0
94 a.a.

Protein Preferred Names

Protein Names

selenoprotein K

SELENOK Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SELENOK	Q9Y6D0	SLC30A8	Homo sapiens	Q8IWU4	Y2H Prey Pooling	32296183
Intra	SELENOK	Q9Y6D0	SLC30A8	Homo sapiens	Q8IWU4	Y2H Array	32296183
Intra	SELENOK	Q9Y6D0	IL10RA	Homo sapiens	Q13651	Y2H Prey Pooling	32296183
Intra	SELENOK	Q9Y6D0	IL10RA	Homo sapiens	Q13651	Y2H Array	32296183
Intra	SELENOK	Q9Y6D0	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	SELENOK	Q9Y6D0	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	SELENOK	Q9Y6D0	STOM	Homo sapiens	P27105	Y2H Prey Pooling	32296183
Intra	SELENOK	Q9Y6D0	STOM	Homo sapiens	P27105	Y2H Array	32296183
Intra	SELENOK	Q9Y6D0	TMPRSS2	Homo sapiens	O15393-2	Y2H Array	32296183
Intra	SELENOK	Q9Y6D0	TMPRSS2	Homo sapiens	O15393-2	Y2H Prey Pooling	32296183
Intra	SELENOK	Q9Y6D0	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	SELENOK	Q9Y6D0	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	SELENOK	Q9Y6D0	SLC35E3	Homo sapiens	Q7Z769	Y2H Prey Pooling	32296183
Intra	SELENOK	Q9Y6D0	SLC35E3	Homo sapiens	Q7Z769	Y2H Array	32296183
Intra	SELENOK	Q9Y6D0	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	SELENOK	Q9Y6D0	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	SELENOK	Q9Y6D0	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Prey Pooling	32296183
Intra	SELENOK	Q9Y6D0	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Array	32296183
Intra	SELENOK	Q9Y6D0	MMD	Homo sapiens	Q15546	Y2H Array	32296183
Intra	SELENOK	Q9Y6D0	MMD	Homo sapiens	Q15546	Y2H Prey Pooling	32296183
Intra	SELENOK	Q9Y6D0	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
Intra	SELENOK	Q9Y6D0	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
Intra	SELENOK	Q9Y6D0	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	SELENOK	Q9Y6D0	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	SELENOK	Q9Y6D0	AMIGO1	Homo sapiens	Q86WK6	Y2H Prey Pooling	32296183
Intra	SELENOK	Q9Y6D0	AMIGO1	Homo sapiens	Q86WK6	Y2H Array	32296183
Intra	SELENOK	Q9Y6D0	STMN4	Homo sapiens	Q9H169-2	Y2H Prey Pooling	32296183
Intra	SELENOK	Q9Y6D0	STMN4	Homo sapiens	Q9H169-2	Y2H Array	32296183
Intra	SELENOK	Q9Y6D0	RNF19B	Homo sapiens	Q6ZMZ0	Y2H Prey Pooling	32296183
Intra	SELENOK	Q9Y6D0	RNF19B	Homo sapiens	Q6ZMZ0	Y2H Array	32296183
Intra	SELENOK	Q9Y6D0	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	SELENOK	Q9Y6D0	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	SELENOK	Q9Y6D0	CNR2	Homo sapiens	P34972	Y2H Prey Pooling	32296183
Intra	SELENOK	Q9Y6D0	CNR2	Homo sapiens	P34972	Y2H Array	32296183
Intra	SELENOK	Q9Y6D0	MFSD6	Homo sapiens	Q6ZSS7	Y2H Array	32296183
Intra	SELENOK	Q9Y6D0	MFSD6	Homo sapiens	Q6ZSS7	Y2H Prey Pooling	32296183
Intra	SELENOK	Q9Y6D0	COMT	Homo sapiens	P21964	Y2H Array	32296183
Intra	SELENOK	Q9Y6D0	COMT	Homo sapiens	P21964	Y2H Prey Pooling	32296183
Intra	SELENOK	Q9Y6D0	GORAB	Homo sapiens	Q5T7V8	Y2H Prey Pooling	32296183
Intra	SELENOK	Q9Y6D0	GORAB	Homo sapiens	Q5T7V8	Y2H Array	32296183
Intra	SELENOK	Q9Y6D0	SLC10A1	Homo sapiens	Q14973	Y2H Prey Pooling	32296183
Intra	SELENOK	Q9Y6D0	SLC10A1	Homo sapiens	Q14973	Y2H Array	32296183
Intra	SELENOK	Q9Y6D0	MTIF3	Homo sapiens	Q9H2K0	Y2H Prey Pooling	32296183
Intra	SELENOK	Q9Y6D0	MTIF3	Homo sapiens	Q9H2K0	Y2H Array	32296183
Intra	SELENOK	Q9Y6D0	MRM1	Homo sapiens	Q6IN84	Y2H Prey Pooling	32296183
Intra	SELENOK	Q9Y6D0	MRM1	Homo sapiens	Q6IN84	Y2H Array	32296183
Intra	SELENOK	Q9Y6D0	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	SELENOK	Q9Y6D0	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	SELENOK	Q9Y6D0	BIK	Homo sapiens	Q13323	Y2H Prey Pooling	32296183
Intra	SELENOK	Q9Y6D0	BIK	Homo sapiens	Q13323	Y2H Array	32296183
Intra	SELENOK	Q9Y6D0	C6orf47	Homo sapiens	O95873	Y2H Array	32296183
Intra	SELENOK	Q9Y6D0	C6orf47	Homo sapiens	O95873	Y2H Prey Pooling	32296183
Intra	SELENOK	Q9Y6D0	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	SELENOK	Q9Y6D0	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
Intra	SELENOK	Q9Y6D0	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	SELENOK	Q9Y6D0	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	SELENOK	Q9Y6D0	ccsb orf id: 2260	Homo sapiens	EBI-22326698	Y2H Prey Pooling	32296183
Intra	SELENOK	Q9Y6D0	ccsb orf id: 2260	Homo sapiens	EBI-22326698	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Keshan Disease

Caused By Deficiency Of Selenium In The Diet

Enlarged Heart And Poor Heart Function

Staphyloenterotoxemia

Staphylococcal Food Poisoning	Staphylococcal Toxaemia Due To Food
Staphyloenterotoxicosis

Commensal Bacterial Infectious Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12637	SELENOK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SELENOK	VGNC	VGNC:80714
Rattus norvegicus	SELENOK	RGD	RGD:1303129
Mus musculus	SELENOK	MGD	MGI:1931466

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