TSHZ2 - teashirt zinc finger homeobox 2 Gene

Homo sapiens

Also known as TSH2; ZABC2; ZNF218; OVC10-2; C20orf17

Gene ID: 128553 | Gene type: protein coding

About TSHZ2

Cytogenetic location: 20q13.2 Genomic coordinates (GRCh38): 20:52,972,358-53,495,330 (from NCBI)

This gene has 5 transcripts (splice variants), 204 orthologues and 2 paralogues. Ubiquitous expression in gall bladder (RPKM 3.9), ovary (RPKM 3.7) and 23 other tissues.

Summary

This gene is a member of the teashirt C2H2-type zinc-finger protein family of transcription factors. This gene encodes a protein with five C2H2-type zinc fingers, a homeobox DNA-binding domain and a coiled-coil domain. This nuclear protein is predicted to act as a transcriptional repressor. This gene is thought to play a role in the development and progression of breast and Other types of Cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

TSHZ2 Products(2)

mRNA	Protein	Name
NM_001193421.2	NP_001180350.1	teashirt homolog 2 isoform 2
NM_173485.6	NP_775756.3	teashirt homolog 2 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24407287	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSHZ2 Protein Structure

zf-C2H2_2

0
200
400
600
800
1034 a.a.

Protein Preferred Names

Protein Names

teashirt homolog 2

cell growth-inhibiting protein 7

TSHZ2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TSHZ2	Q9NRE2	CCDC57	Homo sapiens	Q2TAC2-2	Y2H Array	32296183
Intra	TSHZ2	Q9NRE2	CCDC57	Homo sapiens	Q2TAC2-2	Y2H Prey Pooling	32296183
Intra	TSHZ2	Q9NRE2	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	32296183
Intra	TSHZ2	Q9NRE2	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	TSHZ2	Q9NRE2	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	TSHZ2	Q9NRE2	CRACR2B	Homo sapiens	Q8N4Y2-3	Y2H Prey Pooling	32296183
Intra	TSHZ2	Q9NRE2	CRACR2B	Homo sapiens	Q8N4Y2-3	Y2H Array	32296183
Intra	TSHZ2	Q9NRE2	BACH2	Homo sapiens	Q9BYV9	Y2H Array	32296183
Intra	TSHZ2	Q9NRE2	BACH2	Homo sapiens	Q9BYV9	Y2H Prey Pooling	32296183
Intra	TSHZ2	Q9NRE2	PNMA1	Homo sapiens	Q8ND90	Y2H Array	32296183
Intra	TSHZ2	Q9NRE2	PNMA1	Homo sapiens	Q8ND90	Y2H Prey Pooling	32296183
Intra	TSHZ2	Q9NRE2	MCC	Homo sapiens	P23508	Y2H Prey Pooling	32296183
Intra	TSHZ2	Q9NRE2	MCC	Homo sapiens	P23508	Y2H Array	32296183
Intra	TSHZ2	Q9NRE2	CCDC88B	Homo sapiens	A6NC98	Y2H Array	32296183
Intra	TSHZ2	Q9NRE2	CCDC88B	Homo sapiens	A6NC98	Y2H Prey Pooling	32296183
Intra	TSHZ2	Q9NRE2	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	TSHZ2	Q9NRE2	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	TSHZ2	Q9NRE2	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	32296183
Intra	TSHZ2	Q9NRE2	TRAF1	Homo sapiens	Q13077	Y2H Array	32296183
Intra	TSHZ2	Q9NRE2	SPTA1	Homo sapiens	P02549	Y2H Prey Pooling	32296183
Intra	TSHZ2	Q9NRE2	SPTA1	Homo sapiens	P02549	Y2H Array	32296183
Intra	TSHZ2	Q9NRE2	RABEP1	Homo sapiens	Q15276	Y2H Array	32296183
Intra	TSHZ2	Q9NRE2	RABEP1	Homo sapiens	Q15276	Y2H Prey Pooling	32296183
Intra	TSHZ2	Q9NRE2	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	TSHZ2	Q9NRE2	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	TSHZ2	Q9NRE2	GRIPAP1	Homo sapiens	Q4V328	Y2H Array	32296183
Intra	TSHZ2	Q9NRE2	GRIPAP1	Homo sapiens	Q4V328	Y2H Prey Pooling	32296183
Intra	TSHZ2	Q9NRE2	RINT1	Homo sapiens	Q6NUQ1	Y2H Prey Pooling	32296183
Intra	TSHZ2	Q9NRE2	RINT1	Homo sapiens	Q6NUQ1	Y2H Array	32296183
Intra	TSHZ2	Q9NRE2	COG3	Homo sapiens	Q96JB2-2	Y2H Prey Pooling	32296183
Intra	TSHZ2	Q9NRE2	COG3	Homo sapiens	Q96JB2-2	Y2H Array	32296183
Intra	TSHZ2	Q9NRE2	PHAF1	Homo sapiens	Q9BSU1	Y2H Array	32296183
Intra	TSHZ2	Q9NRE2	PHAF1	Homo sapiens	Q9BSU1	Y2H Prey Pooling	32296183
Intra	TSHZ2	Q9NRE2	CNTROB	Homo sapiens	Q8N137	Y2H Prey Pooling	32296183
Intra	TSHZ2	Q9NRE2	CNTROB	Homo sapiens	Q8N137	Y2H Array	32296183
Intra	TSHZ2	Q9NRE2	GIGYF1	Homo sapiens	O75420	Y2H Array	32296183
Intra	TSHZ2	Q9NRE2	GIGYF1	Homo sapiens	O75420	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Autosomal Recessive Alport Syndrome

Alport Syndrome, Recessive Type	Alport Syndrome, Autosomal Recessive
Alport Syndrome Autosomal Recessive	Alport Syndrome Recessive Type
Nephropathy And Deafness

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15149	TSHZ2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TSHZ2	VGNC	VGNC:47904
Mus musculus	TSHZ2	MGD	MGI:2153084
Rattus norvegicus	TSHZ2	RGD	RGD:6490867
Macaca mulatta	TSHZ2	VGNC	VGNC:78875
Bos taurus	TSHZ2	VGNC	VGNC:59371
Felis catus	TSHZ2	VGNC	VGNC:66618

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