TNIP2 - TNFAIP3 interacting protein 2 Gene

Homo sapiens

Also known as KLIP; ABIN2; FLIP1

Gene ID: 79155 | Gene type: protein coding

About TNIP2

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:2,741,648-2,756,336 (from NCBI)

This gene has 7 transcripts (splice variants), 169 orthologues and 2 paralogues. Ubiquitous expression in small intestine (RPKM 12.1), colon (RPKM 11.5) and 25 other tissues.

Summary

This gene encodes a protein which acts as an inhibitor of NFkappaB activation. The encoded protein is also involved in MAP/ERK signaling pathway in specific cell types. It may be involved in Apoptosis of endothelial cells. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the X chromosome.[provided by RefSeq, May 2014]

TNIP2 Products(3)

mRNA	Protein	Name
NM_001161527.2	NP_001154999.1	TNFAIP3-interacting protein 2 isoform 2
NM_001292016.2	NP_001278945.1	TNFAIP3-interacting protein 2 isoform 3
NM_024309.4	NP_077285.3	TNFAIP3-interacting protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables polyubiquitin modification-dependent protein binding	IDA IDA: Inferred from direct assay	18212736	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12595760	GOA
enables protein kinase binding	IDA IDA: Inferred from direct assay	21784860	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of endothelial cell apoptotic process	IDA IDA: Inferred from direct assay	12933576	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	21784860	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12753905	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNIP2 Protein Structure

EABR

0
100
200
300
400
429 a.a.

Protein Preferred Names

Protein Names

TNFAIP3-interacting protein 2

A20-binding inhibitor of NF-kappaB activation-2

TNIP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TNIP2	Q8NFZ5	NFKB1	Homo sapiens	P19838-1	Anti Bait CoIP	15169888
Intra	TNIP2	Q8NFZ5	NFKB1	Homo sapiens	P19838-1	Pull Down	15169888
Intra	TNIP2	Q8NFZ5	STK11	Homo sapiens	Q15831	Y2H	12753905
Intra	TNIP2	Q8NFZ5	REL	Homo sapiens	Q04864	TAP	14743216
Intra	TNIP2	Q8NFZ5	MAP3K8	Homo sapiens	P41279	Anti Tag CoIP	15169888
Intra	TNIP2	Q8NFZ5	MAP3K8	Homo sapiens	P41279	Pull Down	15169888
Intra	TNIP2	Q8NFZ5	MAP3K8	Homo sapiens	P41279	TAP	14743216
Intra	TNIP2	Q8NFZ5	MAP3K8	Homo sapiens	P41279	Anti Bait CoIP	15169888
Intra	TNIP2	Q8NFZ5	TNFAIP3	Homo sapiens	P21580	Pull Down	15169888
Intra	TNIP2	Q8NFZ5	TNFAIP3	Homo sapiens	P21580	ViroTrap	30561431
Intra	TNIP2	Q8NFZ5	TNFAIP3	Homo sapiens	P21580	CoIP	11389905
Intra	TNIP2	Q8NFZ5	IKBKG	Homo sapiens	Q9Y6K9	Pull Down	14653779
Intra	TNIP2	Q8NFZ5	IKBKG	Homo sapiens	Q9Y6K9	ViroTrap	30561431
Intra	TNIP2	Q8NFZ5	IKBKG	Homo sapiens	Q9Y6K9	Y2H	21988832

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Rabies

Lyssa	Hydrophobia
St Hubert Disease

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14835	TNIP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TNIP2	VGNC	VGNC:79182
Bos taurus	TNIP2	VGNC	VGNC:54503
Mus musculus	TNIP2	MGD	MGI:2386643
Felis catus	TNIP2	VGNC	VGNC:66417
Rattus norvegicus	TNIP2	RGD	RGD:1307717
Canis familiaris	TNIP2	VGNC	VGNC:47677

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