LIN54 - lin-54 DREAM MuvB core complex component Gene

Homo sapiens

Also known as TCX1; JC8.6; CXCDC1; MIP120

Gene ID: 132660 | Gene type: protein coding

About LIN54

Cytogenetic location: 4q21.22 Genomic coordinates (GRCh38): 4:82,924,603-83,012,941 (from NCBI)

This gene has 10 transcripts (splice variants), 206 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 5.1), esophagus (RPKM 4.0) and 25 other tissues.

Summary

LIN54 is a component of the LIN, or DREAM, complex, an essential regulator of cell cycle genes (Schmit et al., 2009 [PubMed 19725879]).[supplied by OMIM, Dec 2010]

LIN54 Products(5)

mRNA	Protein	Name
NM_001115007.3	NP_001108479.1	protein lin-54 homolog isoform b
NM_001115008.3	NP_001108480.1	protein lin-54 homolog isoform b
NM_001288996.2	NP_001275925.1	protein lin-54 homolog isoform c
NM_001288997.1	NP_001275926.1	protein lin-54 homolog isoform b
NM_194282.4	NP_919258.2	protein lin-54 homolog isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables minor groove of adenine-thymine-rich DNA binding	IDA IDA: Inferred from direct assay	27465258	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17531812	GOA
enables transcription regulatory region nucleic acid binding	IDA IDA: Inferred from direct assay	27465258	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within nucleosome organization	IDA IDA: Inferred from direct assay	27465258	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription repressor complex	IDA IDA: Inferred from direct assay	27465258	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LIN54 Protein Structure

TCR

0
200
400
600
749 a.a.

Protein Preferred Names

Protein Names

protein lin-54 homolog

CXC domain-containing protein 1

LIN54 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LIN54	Q6MZP7	BANP	Homo sapiens	Q8N9N5-2	Validated Y2H	32296183
Intra	LIN54	Q6MZP7	BANP	Homo sapiens	Q8N9N5-2	Y2H Prey Pooling	32296183
Intra	LIN54	Q6MZP7	BANP	Homo sapiens	Q8N9N5-2	Y2H Array	32296183
Intra	LIN54	Q6MZP7	MYBL2	Homo sapiens	P10244	Anti Tag CoIP	19725879
Intra	LIN54	Q6MZP7	MYBL2	Homo sapiens	P10244	Anti Bait CoIP	17531812
Intra	LIN54	Q6MZP7	SF3A2	Homo sapiens	Q15428	Y2H Array	32296183
Intra	LIN54	Q6MZP7	SF3A2	Homo sapiens	Q15428	Y2H Prey Pooling	32296183
Intra	LIN54	Q6MZP7	ZNF143	Homo sapiens	P52747	Y2H Prey Pooling	32296183
Intra	LIN54	Q6MZP7	ZNF143	Homo sapiens	P52747	Y2H Array	32296183
Intra	LIN54	Q6MZP7	SP3	Homo sapiens	Q02447	Y2H Prey Pooling	32296183
Intra	LIN54	Q6MZP7	SP3	Homo sapiens	Q02447	Y2H Array	32296183
Intra	LIN54	Q6MZP7	ZNF76	Homo sapiens	P36508	Y2H Prey Pooling	32296183
Intra	LIN54	Q6MZP7	ZNF76	Homo sapiens	P36508	Y2H Array	32296183
Intra	LIN54	Q6MZP7	RBL2	Homo sapiens	Q08999	Anti Tag CoIP	19725879
Intra	LIN54	Q6MZP7	RBL2	Homo sapiens	Q08999	Anti Bait CoIP	17531812

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spondyloarthropathy 1

Ankylosing Spondylitis	Spondyloarthropathy, Susceptibility To, 1
SPDA1	Marie-Strumpell Spondylitis
Bechterew Syndrome	Spa
Spondylarthritis Ankylopoietica	Reiter Syndrome
Ankylosing Spondylitis, Susceptibility To	Bekhterev Syndrome
Bekhterev'S Disease	Marie-Strumpell Disease
Axial Spondylarthritis	Bechterew Disease
Marie-Struempell Disease	Spondylitis Ankylopoietica
Spondyloarthritis	Spondyloarthritis Ankylopoietica
Spas	Ankylosing Spondylarthritis
Psoriatic Arthritis	Reactive Arthritis
Rheumatoid Spondylitis	Spondylitis Ankylosans
Spondylitis Ankylosing	Spondylitis, Ankylosing
Spondylarthropathies	Arthritis, Psoriatic
Arthritis, Reactive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07675	LIN54 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LIN54	MGD	MGI:2140902
Canis familiaris	LIN54	VGNC	VGNC:42685
Bos taurus	LIN54	VGNC	VGNC:30894
Rattus norvegicus	LIN54	RGD	RGD:1311361
Felis catus	LIN54	VGNC	VGNC:63232
Macaca mulatta	LIN54	VGNC	VGNC:74123

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