2. Gene
  3. RBL2 - RB transcriptional corepressor like 2 Gene

RBL2 - RB transcriptional corepressor like 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Rb2; P130; BRUWAG

Gene ID: 5934 | Gene type: protein coding

About RBL2

Cytogenetic location: 16q12.2 Genomic coordinates (GRCh38): 16:53,434,471-53,491,648 (from NCBI)

This gene has 9 transcripts (splice variants), 211 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 41.9), testis (RPKM 38.9) and 25 other tissues.

Summary

Enables promoter-specific chromatin binding activity. Involved in regulation of lipid kinase activity. Acts upstream of or within negative regulation of gene expression. Located in chromosome; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

RBL2 Products(5)

mRNA Protein Name
NM_001323608.2 NP_001310537.1 retinoblastoma-like protein 2 isoform 1
NM_001323609.2 NP_001310538.1 retinoblastoma-like protein 2 isoform 2
NM_001323610.2 NP_001310539.1 retinoblastoma-like protein 2 isoform 3
NM_001323611.1 NP_001310540.1 retinoblastoma-like protein 2 isoform 4
NM_005611.4 NP_005602.3 retinoblastoma-like protein 2 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
25100735 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
1331501 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
25100735 GOA
involved in regulation of lipid kinase activity IDA
IDA: Inferred from direct assay
16286473 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBL2 Protein Structure

DUF3452

DUF3452: Domain of unknown function (DUF3452) (101 - 239)

RB_A

RB_A: Retinoblastoma-associated protein A domain (417 - 609)

RB_B

RB_B: Retinoblastoma-associated protein B domain (834 - 1018)

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  • 1139 a.a.
Protein Preferred Names Protein Names

retinoblastoma-like protein 2

130 kDa retinoblastoma-associated protein

RBL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
RBL2 Q08999 RBBP8 Homo sapiens Q99708-2
Y2H Prey Pooling
32296183
Intra
RBL2 Q08999 RBBP8 Homo sapiens Q99708-2
Validated Y2H
32296183
Intra
RBL2 Q08999 RBBP8 Homo sapiens Q99708-2
Y2H Array
32296183
Intra
RBL2 Q08999 RBBP8 Homo sapiens I6L8A6
Y2H
27107012
Intra
RBL2 Q08999 RBBP8 Homo sapiens I6L8A6
BFG-2H
27107012
Cross
RBL2 Q08999 Pax3 Mus musculus P24610
Anti Bait CoIP
9464541
Cross
RBL2 Q08999 Pax3 Mus musculus P24610
Y2H
9464541
Cross
RBL2 Q08999 Vsx2 Mus musculus Q61412
Y2H
9464541
Cross
RBL2 Q08999 Vsx2 Mus musculus Q61412
Pull Down
9464541
Intra
RBL2 Q08999 LIN54 Homo sapiens Q6MZP7
Anti Tag CoIP
17531812
Intra
RBL2 Q08999 LIN54 Homo sapiens Q6MZP7
Anti Bait CoIP
17531812
Cross
RBL2 Q08999 Sirt1 Mus musculus Q923E4
Anti Tag CoIP
17620057
Intra
RBL2 Q08999 CDK4 Homo sapiens P11802
Protein Kinase Assay
22094256
Intra
RBL2 Q08999 E2F4 Homo sapiens Q16254
Anti Bait CoIP
17531812
Intra
RBL2 Q08999 E2F4 Homo sapiens Q16254
Anti Tag CoIP
17531812
Intra
RBL2 Q08999 E2F4 Homo sapiens Q16254
Anti Bait CoIP
22002537
Intra
RBL2 Q08999 PPP2CA Homo sapiens P67775
Phosphatase Assay
15467457
Intra
RBL2 Q08999 DGKZ Homo sapiens Q13574-2
Pull Down
16286473
Cross
RBL2 Q08999 e1a_ade05 Human adenovirus C P03255
Pull Down
1331501
Cross
RBL2 Q08999 e1a_ade05 Human adenovirus C P03255
Affinity Techniques
1331501
Cross: Cross-species interaction Intra: Intraspecies interaction

RBL2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81302 Phospho-Rb2 p130 (Ser952) Antibody (YA1034) WB, IHC-F, IHC-P, ICC/IF Human
HY-P81302A Phospho-Rb2 p130 (Thr986) Antibody (YA1035) WB, IP Human

Related Diseases

Diseases Alias
Brunet-Wagner Neurodevelopmental Syndrome

BRUWAG
Retinoblastoma

RB

Trilateral Retinoblastoma

RB1

Retinoblastoma, Trilateral

Neuroblastoma Of Retina

Rb - Retinoblastoma

Eye Cancer, Retinoblastoma

Retinal Cancer

Retinal Tumor

Glioma, Retinal

Non-Hereditary Retinoblastoma

Childhood Cancer Retinoblastoma

Malignant Neoplasm Of Retina

Retinal Neoplasms
Papilloma

Papillomatosis
Spastic Paraplegia 27, Autosomal Recessive

SPG27

Hereditary Spastic Paraplegia 27

Autosomal Recessive Spastic Paraplegia Type 27

Autosomal Recessive Spastic Paraplegia 27

Spastic Paraplegia-27, Autosomal Recessive
Bilateral Retinoblastoma
Unilateral Retinoblastoma
Burkitt Lymphoma

Burkitt'S Lymphoma

BL

Burkitt Lymphoma, Somatic

Burkitt Lymphoma/Leukaemia

Burkitt'S Tumor

Burkitt'S Tumor Or Lymphoma

Malignant Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma

Burkitt Tumor

Burkitts Lymphoma

Lymphoma, Small Noncleaved-Cell

Burkitt Tumour

Diffuse Small Noncleaved Malignant Burkitt Lymphoma

Malignant Burkitt Lymphoma

“Burkitt-Like” Lymphoma

Undifferentiated Burkitt Lymphoma

Small Noncleaved Cell Burkitt Lymphoma
Retinal Cancer

Malignant Neoplasm Of Retina

Retinal Neoplasms

Malignant Retinal Neoplasm

Malignant Tumor Of Retina

Neoplasm Of Retina

Retinal Tumor

Retinal Neoplasm

Cancer Of The Retina

Malignant Retinal Tumour

Malignant Tumour Of Retina

Primary Malignant Neoplasm Of Retina
Familial Retinoblastoma

Hereditary Retinoblastoma

Retinoblastoma
Eye Disease

Eye Diseases

Abnormality Of The Eye

Toxoplasma Oculopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12504 Pyr6 Inhibitor 98.47% Unkown
HY-N2252 Licarin A Inhibitor 98.48% Unkown
HY-139247 pNPS-DHA / Unkown
HY-N8593 Undecane Inhibitor ≥98.0% Unkown
HY-N8593S Undecane-d24 / Unkown
HY-P1640 (Trp63,Trp64)​-​C3a(63-77) Agonist / Unkown
HY-RS11730 RBL2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-N12116 Maceneolignan A Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RBL2 RGD RGD:3541
Canis familiaris RBL2 VGNC VGNC:45403
Macaca mulatta RBL2 VGNC VGNC:99582
Bos taurus RBL2 VGNC VGNC:33782
Felis catus RBL2 VGNC VGNC:69261
Mus musculus RBL2 MGD MGI:105085