Dnmt1 - DNA methyltransferase (cytosine-5) 1 Gene

Mus musculus

Also known as Dnmt; MCMT; Met1; Cxxc9; MTase; Met-1; Dnmt1o; m.MmuI; MommeD2

Gene ID: 13433 | Gene type: protein coding

About Dnmt1

Chromosome 9: 20,818,505-20,871,184 reverse strand.GRCm39:CM001002.3

This gene has 7 transcripts (splice variants), 215 orthologues, 1 paralogue and is associated with 21 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 37.3), thymus adult (RPKM 36.6) and 27 other tissues.

Summary

This gene encodes a methyltransferase that preferentially methylates cytosines of CpG residues in hemimethylated DNA to generate fully methylated CpG base pairs during DNA replication. This Enzyme plays roles in diverse cellular processes including cell cycle regulation, DNA repair, and telomere maintenance. The encoded protein is composed of an N-terminal domain with a nuclear localization sequence and replication fork-targeting domain, a DNA-binding CXXC domain, two bromo-adjacent homology domains, and a C-terminal catalytic domain. Mouse embryonic stem cells mutant for this gene are viable, but when introduced into the germ line, cause a recessive lethal phenotype with mutant embryos displaying stunted growth and developmental defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Dnmt1 Products(6)

mRNA	Protein	Name
NM_001199431.2	NP_001186360.2	DNA (cytosine-5)-methyltransferase 1 isoform 1
NM_001199432.2	NP_001186361.1	DNA (cytosine-5)-methyltransferase 1 isoform 3
NM_001314011.2	NP_001300940.1	DNA (cytosine-5)-methyltransferase 1 isoform 5
NM_001199433.2	NP_001186362.1	DNA (cytosine-5)-methyltransferase 1 isoform 4
NM_001404685.2	NP_001391614.2	DNA (cytosine-5)-methyltransferase 1 isoform 6
NM_010066.5	NP_034196.5	DNA (cytosine-5)-methyltransferase 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA (cytosine-5-)-methyltransferase activity	IDA IDA: Inferred from direct assay	11399088	MGI
enables DNA binding	IDA IDA: Inferred from direct assay	11399088	MGI
enables DNA-methyltransferase activity	IMP IMP: Inferred from mutant phenotype	1606615	MGI
enables RNA binding	IDA IDA: Inferred from direct assay	20573698	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	24105743	MGI
enables lncRNA binding	IDA IDA: Inferred from direct assay	25686699	MGI
enables methyl-CpG binding	IDA IDA: Inferred from direct assay	20573698	MGI
enables methyltransferase activity	IDA IDA: Inferred from direct assay	10615135	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10615135	MGI
enables zinc ion binding	IDA IDA: Inferred from direct assay	11399088	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA methylation-dependent heterochromatin formation	IDA IDA: Inferred from direct assay	10615135	MGI
acts upstream of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17245608	MGI
acts upstream of or within cellular response to amino acid stimulus	IDA IDA: Inferred from direct assay	20548288	MGI
acts upstream of or within cellular response to bisphenol A	IDA IDA: Inferred from direct assay	21980460	MGI
acts upstream of or within chromosomal DNA methylation maintenance following DNA replication	IDA IDA: Inferred from direct assay	11399088	MGI
acts upstream of or within chromosomal DNA methylation maintenance following DNA replication	IGI IGI: Inferred from genetic interaction	27841881	MGI
acts upstream of or within chromosomal DNA methylation maintenance following DNA replication	IMP IMP: Inferred from mutant phenotype	16887828	MGI
acts upstream of or within epigenetic programming of gene expression	IGI IGI: Inferred from genetic interaction	27841881	MGI
acts upstream of or within epigenetic programming of gene expression	IMP IMP: Inferred from mutant phenotype	1606615	MGI
acts upstream of or within positive effect epigenetic programming of gene expression	IMP IMP: Inferred from mutant phenotype	29117290	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17245608	MGI
acts upstream of or within negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	29117290	MGI
involved in negative regulation of gene expression via chromosomal CpG island methylation	IMP IMP: Inferred from mutant phenotype	17576694	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10888872	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16887828	MGI
acts upstream of or within regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	10919675	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	16491076	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in female germ cell nucleus	IDA IDA: Inferred from direct assay	15063176	MGI
located in germ cell nucleus	IDA IDA: Inferred from direct assay	15063176	MGI
located in heterochromatin	IDA IDA: Inferred from direct assay	14519686	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11942627	MGI
located in pericentric heterochromatin	IDA IDA: Inferred from direct assay	17576694	MGI
located in replication fork	IDA IDA: Inferred from direct assay	10888872	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Dnmt1 Protein Structure

DMAP_binding

PRK12678

DNMT1-RFD

zf-CXXC

BAH_Dnmt1_I

BAH_Dnmt1_II

Dcm

0
300
600
900
1200
1500
1620 a.a.

Protein Preferred Names

Protein Names

DNA (cytosine-5)-methyltransferase 1

DNA MTase MmuI

DNA methyltransferase MmuI

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-A0004	Decitabine	Inhibitor	99.97%	Yes
HY-10586	5-Azacytidine	Inhibitor	99.91%	Yes
HY-B2194	γ-Oryzanol	Inhibitor	98.30%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15229	Guadecitabine sodium	Inhibitor	98.05%	Phase 3

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-135146	GSK-3484862	Inhibitor	99.95%	Unkown
HY-13642	RG108	Inhibitor	99.85%	Unkown
HY-13962	SGI-1027	Inhibitor	99.77%	Unkown
HY-13420	Zebularine	Inhibitor	99.99%	Unkown
HY-B2230	Hinokitiol	Inhibitor	99.83%	Unkown
HY-101925	CM-272	Inhibitor	98.70%	Unkown
HY-117421A	CM-579 trihydrochloride	Inhibitor	97.00%	Unkown
HY-12747	DC_517	Inhibitor	99.67%	Unkown
HY-139664A	(R)-GSK-3685032	Inhibitor	98.97%	Unkown
HY-12746	DC-05	Inhibitor	98.96%	Unkown
HY-139015	5-Aza-4'-thio-2'-deoxycytidine	Inhibitor	99.09%	Unkown
HY-117421	CM-579	Inhibitor	/	Unkown
HY-161694	DNMT1-IN-3	Inhibitor	/	Unkown
HY-19826	Isofistularin-3	Inhibitor	/	Unkown
HY-163803	CM-444	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dnmt1	NCBI	NCBI:1786

Name
Email *

	Sorry, but the email address you supplied was invalid.