2. Epigenetics
  3. DNA Methyltransferase
  4. MS9024

MS9024 is the degrader for DNA methyltransferase 1 that degrades DNMT1 in cell HCT116 through the ubiquitin-proteasome pathway with a DC50 of 35 nM (DC50 in MDA-MB-468 and H1299 is 254 nM and 101 nM). MS9024 also inhibits DNMT1 with an IC50 of 0.43 μM.

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MS9024 Chemical Structure

MS9024 Chemical Structure

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MS9024 Related Antibodies

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DNA Methyltransferase DNMT1 DNMT3 MGMT

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Description

MS9024 is the degrader for DNA methyltransferase 1 that degrades DNMT1 in cell HCT116 through the ubiquitin-proteasome pathway with a DC50 of 35 nM (DC50 in MDA-MB-468 and H1299 is 254 nM and 101 nM). MS9024 also inhibits DNMT1 with an IC50 of 0.43 μM[1].

IC50 & Target

DNMT1

430 nM (IC50)

Molecular Weight

422.50

Formula

C21H22N6O2S
SMILES

CCC1=C(C(SC(C2=CC=CC=C2)C(N)=O)=NC(N(CC(NC)=O)C)=C1C#N)C#N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MS9024 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MS9024MS 9024MS-9024DNA MethyltransferaseDNMTsDNA MTasesMDA-MB-468H1299HCT116Inhibitorinhibitorinhibit

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