GPR151 - G protein-coupled receptor 151 Gene

Homo sapiens

Also known as GPCR; PGR7; GALR4; GALRL; GPCR-2037

Gene ID: 134391 | Gene type: protein coding

About GPR151

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:146,513,144-146,516,190 (from NCBI)

This gene has 1 transcript (splice variant), 176 orthologues and 7 paralogues.

Summary

This gene encodes an orphan member of the class A rhodopsin-like family of G-protein-coupled receptors (GPCRs). Within the rhodopsin-like family, this gene is a member of the SOG subfamily that includes somatostatin, opioid, Galanin, and kisspeptin receptors. The orthologous mouse gene has a restricted pattern of neuronal expression which is induced following nerve injury. All GPCRs have a transmembrane domain that includes seven transmembrane alpha-helices. A general feature of GPCR signaling is the agonist-induced conformational change in the receptor, leading to activation of the heterotrimeric G protein. The activated G protein then binds to and activates numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017]

GPR151 Products(1)

mRNA	Protein	Name
NM_194251.3	NP_919227.2	G-protein coupled receptor 151

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled receptor activity	IMP IMP: Inferred from mutant phenotype	31119277	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	31119277	GOA
involved in response to acidic pH	IMP IMP: Inferred from mutant phenotype	31119277	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR151 Protein Structure

7tm_1

0
100
200
300
419 a.a.

Protein Preferred Names

Protein Names

G-protein coupled receptor 151

G-protein coupled receptor PGR7

GPR151 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GPR151	Q8TDV0	SLC41A2	Homo sapiens	Q96JW4	Validated Y2H	32296183
Intra	GPR151	Q8TDV0	PGRMC2	Homo sapiens	O15173	Y2H Prey Pooling	32296183
Intra	GPR151	Q8TDV0	PGRMC2	Homo sapiens	O15173	Y2H Array	32296183
Intra	GPR151	Q8TDV0	TMEM239	Homo sapiens	Q8WW34-2	Validated Y2H	32296183
Intra	GPR151	Q8TDV0	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	GPR151	Q8TDV0	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	GPR151	Q8TDV0	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	GPR151	Q8TDV0	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Array	32296183
Intra	GPR151	Q8TDV0	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Prey Pooling	32296183
Intra	GPR151	Q8TDV0	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	GPR151	Q8TDV0	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	GPR151	Q8TDV0	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	GPR151	Q8TDV0	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	GPR151	Q8TDV0	UNC93A	Homo sapiens	Q86WB7-2	Y2H Array	32296183
Intra	GPR151	Q8TDV0	UNC93A	Homo sapiens	Q86WB7-2	Y2H Prey Pooling	32296183
Intra	GPR151	Q8TDV0	SCN3B	Homo sapiens	Q9NY72	Validated Y2H	32296183
Intra	GPR151	Q8TDV0	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	GPR151	Q8TDV0	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	GPR151	Q8TDV0	SSMEM1	Homo sapiens	Q8WWF3	Validated Y2H	32296183
Intra	GPR151	Q8TDV0	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	GPR151	Q8TDV0	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	GPR151	Q8TDV0	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	GPR151	Q8TDV0	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	GPR151	Q8TDV0	SLC18A1	Homo sapiens	P54219-3	Y2H Prey Pooling	32296183
Intra	GPR151	Q8TDV0	SLC18A1	Homo sapiens	P54219-3	Y2H Array	32296183
Intra	GPR151	Q8TDV0	SLC18A2	Homo sapiens	Q05940	Y2H Array	32296183
Intra	GPR151	Q8TDV0	SLC18A2	Homo sapiens	Q05940	Y2H Prey Pooling	32296183
Intra	GPR151	Q8TDV0	SHISAL1	Homo sapiens	Q3SXP7	Y2H Prey Pooling	32296183
Intra	GPR151	Q8TDV0	SHISAL1	Homo sapiens	Q3SXP7	Y2H Array	32296183
Intra	GPR151	Q8TDV0	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	GPR151	Q8TDV0	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	GPR151	Q8TDV0	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	GPR151	Q8TDV0	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	GPR151	Q8TDV0	CGRRF1	Homo sapiens	Q99675	Validated Y2H	32296183
Intra	GPR151	Q8TDV0	CGRRF1	Homo sapiens	Q99675	Y2H Array	32296183
Intra	GPR151	Q8TDV0	CGRRF1	Homo sapiens	Q99675	Y2H Prey Pooling	32296183
Intra	GPR151	Q8TDV0	CERS4	Homo sapiens	Q9HA82	Validated Y2H	32296183
Intra	GPR151	Q8TDV0	CERS4	Homo sapiens	Q9HA82	Y2H Prey Pooling	32296183
Intra	GPR151	Q8TDV0	CERS4	Homo sapiens	Q9HA82	Y2H Array	32296183
Intra	GPR151	Q8TDV0	CYBC1	Homo sapiens	Q9BQA9	Validated Y2H	32296183
Intra	GPR151	Q8TDV0	MANBAL	Homo sapiens	Q9NQG1	Validated Y2H	32296183
Intra	GPR151	Q8TDV0	MANBAL	Homo sapiens	Q9NQG1	Y2H Array	32296183
Intra	GPR151	Q8TDV0	MANBAL	Homo sapiens	Q9NQG1	Y2H Prey Pooling	32296183
Intra	GPR151	Q8TDV0	SACM1L	Homo sapiens	Q9NTJ5	Validated Y2H	32296183
Intra	GPR151	Q8TDV0	SLC10A1	Homo sapiens	Q14973	Y2H Array	32296183
Intra	GPR151	Q8TDV0	SLC10A1	Homo sapiens	Q14973	Y2H Prey Pooling	32296183
Intra	GPR151	Q8TDV0	TIMMDC1	Homo sapiens	Q9NPL8	Validated Y2H	32296183
Intra	GPR151	Q8TDV0	TIMMDC1	Homo sapiens	Q9NPL8	Y2H Array	32296183
Intra	GPR151	Q8TDV0	TIMMDC1	Homo sapiens	Q9NPL8	Y2H Prey Pooling	32296183
Intra	GPR151	Q8TDV0	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	GPR151	Q8TDV0	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	GPR151	Q8TDV0	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	GPR151	Q8TDV0	BCL2L2	Homo sapiens	Q92843	Validated Y2H	32296183
Intra	GPR151	Q8TDV0	STX8	Homo sapiens	Q9UNK0	Validated Y2H	32296183
Intra	GPR151	Q8TDV0	KEAP1	Homo sapiens	Q14145	Y2H Prey Pooling	32296183
Intra	GPR151	Q8TDV0	KEAP1	Homo sapiens	Q14145	Y2H Array	32296183
Intra	GPR151	Q8TDV0	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	GPR151	Q8TDV0	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	GPR151	Q8TDV0	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Essential Tremor

Benign Essential Tremor	Familial Tremor
Hereditary Essential Tremor	Essential Hereditary Tremor
Shaky Hand Syndrome	Benign Essential Tremor Syndrome
Tremor Hereditary Essential	Essential Tremor, Susceptibility To
Tremor, Hereditary Essential

Tremor, Hereditary Essential, 4

ETM4	Essential Tremor 4
Essential Tremor, Hereditary, 4	Hereditary Essential Tremor 4
Tremor, Hereditary Essential 4	Tremor, Hereditary Essential, Type 4

Brachial Plexus Lesion

Brachial Plexus Injuries

Brachial Plexus Lesions

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05670	GPR151 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GPR151	VGNC	VGNC:29558
Canis familiaris	GPR151	VGNC	VGNC:41405
Mus musculus	GPR151	MGD	MGI:2441887
Rattus norvegicus	GPR151	RGD	RGD:727873
Felis catus	GPR151	VGNC	VGNC:62679
Macaca mulatta	GPR151	VGNC	VGNC:72987

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