Ephb2 - Eph receptor B2 Gene

Mus musculus

Also known as Drt; Erk; Nuk; Cek5; Hek5; Qek5; Sek3; ETECK; Prkm5; Tyro5

Gene ID: 13844 | Gene type: protein coding

About Ephb2

Summary

This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors consist of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. The encoded receptor preferentially binds membrane-bound ephrin-B ligands and is involved in nervous system and vascular development. This gene is used as a marker of intestinal stem cells. Homozygous knockout mice for this gene exhibit impaired axon guidance and vestibular function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Ephb2 Products(2)

mRNA	Protein	Name
NM_001290753.2	NP_001277682.1	ephrin type-B receptor 2 isoform 1 precursor
NM_010142.4	NP_034272.1	ephrin type-B receptor 2 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables amyloid-beta binding	IPI IPI: Inferred from physical interaction	21113149	MGI
enables axon guidance receptor activity	IDA IDA: Inferred from direct assay	11532925	MGI
enables ephrin receptor activity	IDA IDA: Inferred from direct assay	11780069	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	16977320	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9883737	MGI
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	9883737	MGI
enables protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	21113149	MGI
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	21113149	MGI
enables signaling receptor activity	IDA IDA: Inferred from direct assay	11780069	MGI
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	11754835	MGI
enables transmembrane-ephrin receptor activity	IDA IDA: Inferred from direct assay	21029865	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in angiogenesis	IMP IMP: Inferred from mutant phenotype	9990854	MGI
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	15223334	MGI
acts upstream of or within axon guidance	IDA IDA: Inferred from direct assay	11532925	MGI
involved in axon guidance	IMP IMP: Inferred from mutant phenotype	8947026	MGI
involved in axonal fasciculation	IMP IMP: Inferred from mutant phenotype	8947026	MGI
acts upstream of axonogenesis	IDA IDA: Inferred from direct assay	12971893	MGI
acts upstream of or within camera-type eye morphogenesis	IMP IMP: Inferred from mutant phenotype	12971893	MGI
acts upstream of or within cell morphogenesis	IGI IGI: Inferred from genetic interaction	17686994	MGI
acts upstream of or within cell surface receptor protein tyrosine kinase signaling pathway	IDA IDA: Inferred from direct assay	14988728	MGI
acts upstream of or within central nervous system projection neuron axonogenesis	IMP IMP: Inferred from mutant phenotype	12971893	MGI
involved in commissural neuron axon guidance	IMP IMP: Inferred from mutant phenotype	8689685	MGI
involved in corpus callosum development	IMP IMP: Inferred from mutant phenotype	8947026	MGI
involved in dendritic spine development	IMP IMP: Inferred from mutant phenotype	14691139	MGI
acts upstream of or within dendritic spine morphogenesis	IDA IDA: Inferred from direct assay	17310244	MGI
involved in dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	14691139	MGI
acts upstream of or within ephrin receptor signaling pathway	IDA IDA: Inferred from direct assay	17310244	MGI
involved in ephrin receptor signaling pathway	IDA IDA: Inferred from direct assay	21029865	MGI
involved in inner ear morphogenesis	IMP IMP: Inferred from mutant phenotype	10839360	MGI
acts upstream of or within learning	IMP IMP: Inferred from mutant phenotype	11754835	MGI
involved in learning or memory	IGI IGI: Inferred from genetic interaction	21113149	MGI
involved in negative regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	11585923	MGI
involved in negative regulation of NMDA glutamate receptor activity	IMP IMP: Inferred from mutant phenotype	21113149	MGI
involved in negative regulation of Ras protein signal transduction	IDA IDA: Inferred from direct assay	11585923	MGI
acts upstream of or within negative regulation of axonogenesis	IDA IDA: Inferred from direct assay	12971893	MGI
acts upstream of negative regulation of protein kinase activity	IDA IDA: Inferred from direct assay	11585923	MGI
involved in negative regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	11585923	MGI
involved in neuron projection retraction	IDA IDA: Inferred from direct assay	11585923	MGI
acts upstream of or within optic nerve morphogenesis	IMP IMP: Inferred from mutant phenotype	12971893	MGI
acts upstream of or within peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	17686994	MGI
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	21029865	MGI
involved in peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	21113149	MGI
involved in phosphorylation	IDA IDA: Inferred from direct assay	9883737	MGI
involved in positive regulation of NMDA glutamate receptor activity	IMP IMP: Inferred from mutant phenotype	21113149	MGI
acts upstream of or within positive regulation of long-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	11754836	MGI
involved in positive regulation of long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	21113149	MGI
involved in positive regulation of synapse assembly	IDA IDA: Inferred from direct assay	21029865	MGI
involved in positive regulation of synapse assembly	IMP IMP: Inferred from mutant phenotype	14691139	MGI
involved in positive regulation of synaptic plasticity	IGI IGI: Inferred from genetic interaction	21113149	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	12971893	MGI
acts upstream of or within regulation of axonogenesis	IDA IDA: Inferred from direct assay	14988728	MGI
involved in regulation of body fluid levels	IMP IMP: Inferred from mutant phenotype	10839360	MGI
acts upstream of or within regulation of neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	11754835	MGI
involved in regulation of synapse assembly	EXP EXP: Inferred from Experiment	17122040	MGI
involved in regulation of synapse assembly	IDA IDA: Inferred from direct assay	17122040	MGI
involved in regulation of synapse assembly	IMP IMP: Inferred from mutant phenotype	17122040	MGI
acts upstream of or within retinal ganglion cell axon guidance	IDA IDA: Inferred from direct assay	12971893	MGI
involved in roof of mouth development	IMP IMP: Inferred from mutant phenotype	8947026	MGI
involved in urogenital system development	IMP IMP: Inferred from mutant phenotype	15223334	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	8689685	MGI
located in dendrite	IDA IDA: Inferred from direct assay	14691139	MGI
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	17122040	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17122040	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	18410519	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	17122040	MGI
is active in hippocampal mossy fiber to CA3 synapse	IDA IDA: Inferred from direct assay	30185604	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	12971893	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	8689685	MGI
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	18410519	MGI
is active in postsynaptic membrane	IEP IEP: Inferred from expression pattern	18410519	MGI
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	18410519	MGI
is active in presynaptic membrane	IEP IEP: Inferred from expression pattern	18410519	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ephrin type-B receptor 2

neural kinase	nuk receptor tyrosine kinase
tyrosine-protein kinase receptor EPH-3	tyrosine-protein kinase receptor SEK-3

Ephb2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Ephb2	P54763	TIAM1	Homo sapiens	Q13009	Anti Tag CoIP	17440041
Intra	Ephb2	P54763	TIAM1	Homo sapiens	Q13009	Pull Down	17440041
Intra	Ephb2	P54763	P12023-PRO_0000000118	Mus musculus	P12023-PRO_0000000118	Anti Bait CoIP	21113149
Intra	Ephb2	P54763	P12023-PRO_0000000118	Mus musculus	P12023-PRO_0000000118	Pull Down	21113149
Intra	Ephb2	P54763	P12023-PRO_0000000118	Mus musculus	P12023-PRO_0000000118	Anti Tag CoIP	21113149
Intra	Ephb2	P54763	Epha4	Mus musculus	Q03137	Protein Kinase Assay	16977320
Intra	Ephb2	P54763	Arhgef15	Mus musculus	Q5FWH6-2	Anti Tag CoIP	21029865
Intra	Ephb2	P54763	Src	Mus musculus	P05480	IF	16298995
Intra	Ephb2	P54763	Src	Mus musculus	P05480	Anti Bait CoIP	16298995
Intra	Ephb2	P54763	Efnb2	Mus musculus	P52800	X-Ray Diffraction	11780069
Intra	Ephb2	P54763	Ephb2	Mus musculus	P54763	X-Ray Diffraction	16977320
Intra	Ephb2	P54763	Ptk2	Mus musculus	P34152	Anti Bait CoIP	16298995
Intra	Ephb2	P54763	Grip1	Mus musculus	Q925T6	Y2H	9883737
Intra	Ephb2	P54763	Ephb2	Mus musculus	P54763	NMR	16977320
Intra	Ephb2	P54763	Ptk2	Mus musculus	P34152	IF	16298995

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Ephb2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75235	EphB2 Protein, Mouse (HEK293, His)	P54763-3 (V19-K540)	≥95%
HY-P75236	EphB2 Protein, Mouse (HEK293, Fc)	P54763-3/NP_034272.1 (V19-K540)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18833	ALW-II-49-7	Inhibitor	99.80%	Unkown
HY-P5438	Srctide	Substrate	99.93%	Unkown
HY-157019	UniPR1447	Antagonist	99.46%	Unkown
HY-170517	PKMYT1-IN-8	Inhibitor	/	Unkown
HY-146375	UniPR505	Antagonist	/	Unkown
HY-P10630	Pep63	Inhibitor	/	Unkown
HY-RS04434	EPHB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990405	Anti-EphB2 Antibody	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ephb2	NCBI	NCBI:2048
Macaca fascicularis	Ephb2	NCBI	NCBI:102137932

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