TTC5 - tetratricopeptide repeat domain 5 Gene

Homo sapiens

Also known as Strap; NEDCAFD

Gene ID: 91875 | Gene type: protein coding

About TTC5

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:20,286,227-20,305,951 (from NCBI)

This gene has 7 transcripts (splice variants), 199 orthologues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 7.6), thyroid (RPKM 6.4) and 25 other tissues.

Summary

Predicted to enable DNA binding activity and chromatin binding activity. Predicted to be involved in DNA repair. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TTC5 Products(1)

mRNA	Protein	Name
NM_138376.3	NP_612385.2	tetratricopeptide repeat protein 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables ribosome binding	IMP IMP: Inferred from mutant phenotype	31727855	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of mRNA catabolic process	IMP IMP: Inferred from mutant phenotype	31727855	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	31727855	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TTC5 Protein Structure

TPR_11

0
100
200
300
400
440 a.a.

Protein Preferred Names

Protein Names

tetratricopeptide repeat protein 5

TPR repeat protein 5

TTC5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TTC5	Q8N0Z6	HDX	Homo sapiens	Q7Z353	Y2H Array	32296183
Intra	TTC5	Q8N0Z6	HDX	Homo sapiens	Q7Z353	Y2H Prey Pooling	32296183
Intra	TTC5	Q8N0Z6	CAMK2B	Homo sapiens	Q13554	Y2H Prey Pooling	25416956
Intra	TTC5	Q8N0Z6	CAMK2B	Homo sapiens	Q13554	Validated Y2H	25416956
Intra	TTC5	Q8N0Z6	CAMK2B	Homo sapiens	Q13554	Y2H Array	25416956
Intra	TTC5	Q8N0Z6	GOLGA6A	Homo sapiens	Q9NYA3	Y2H Prey Pooling	32296183
Intra	TTC5	Q8N0Z6	GOLGA6A	Homo sapiens	Q9NYA3	Validated Y2H	32296183
Intra	TTC5	Q8N0Z6	GOLGA6A	Homo sapiens	Q9NYA3	Y2H Array	32296183
Intra	TTC5	Q8N0Z6	CAMK2B	Homo sapiens	Q13554-3	Y2H Array	32296183
Intra	TTC5	Q8N0Z6	CAMK2B	Homo sapiens	Q13554-3	Y2H Prey Pooling	32296183
Intra	TTC5	Q8N0Z6	CAMK2D	Homo sapiens	Q13557-8	Y2H Array	32296183
Intra	TTC5	Q8N0Z6	CAMK2D	Homo sapiens	Q13557-8	Y2H Prey Pooling	32296183
Intra	TTC5	Q8N0Z6	CAMK2G	Homo sapiens	Q13555-5	Y2H Prey Pooling	32296183
Intra	TTC5	Q8N0Z6	CAMK2G	Homo sapiens	Q13555-5	Y2H Array	32296183
Intra	TTC5	Q8N0Z6	CAMK2A	Homo sapiens	Q9UQM7	Validated Y2H	32296183
Intra	TTC5	Q8N0Z6	CAMK2A	Homo sapiens	Q9UQM7	Y2H Array	32296183
Intra	TTC5	Q8N0Z6	CAMK2A	Homo sapiens	Q9UQM7	Y2H Prey Pooling	32296183
Intra	TTC5	Q8N0Z6	CAVIN1	Homo sapiens	Q6NZI2	Y2H Array	32296183
Intra	TTC5	Q8N0Z6	CAVIN1	Homo sapiens	Q6NZI2	Y2H Prey Pooling	32296183
Intra	TTC5	Q8N0Z6	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	TTC5	Q8N0Z6	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	TTC5	Q8N0Z6	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Neurodevelopmental Disorder With Cerebral Atrophy And Variable Facial Dysmorphism

NEDCAFD

Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid

Pseudobulbar Palsy

Pseudobulbar Paralysis

Tubulinopathy

Tubulinopathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15216	TTC5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TTC5	RGD	RGD:1311284
Canis familiaris	TTC5	VGNC	VGNC:47960
Mus musculus	TTC5	MGD	MGI:2683584
Felis catus	TTC5	VGNC	VGNC:66674
Bos taurus	TTC5	VGNC	VGNC:36479
Macaca mulatta	TTC5	VGNC	VGNC:79190

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