2. Gene
  3. GCC1 - GRIP and coiled-coil domain containing 1 Gene

GCC1 - GRIP and coiled-coil domain containing 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GCC1P; GCC88

Gene ID: 79571 | Gene type: protein coding

About GCC1

Cytogenetic location: 7q32.1 Genomic coordinates (GRCh38): 7:127,580,628-127,585,596 (from NCBI)

This gene has 3 transcripts (splice variants), 205 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 9.0), bone marrow (RPKM 5.7) and 25 other tissues.

Summary

The protein encoded by this gene is a peripheral membrane protein. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. It may play a role in the organization of trans-Golgi network subcompartment involved with membrane transport. [provided by RefSeq, Jul 2008]

GCC1 Products(1)

mRNA Protein Name
NM_024523.6 NP_078799.2 GRIP and coiled-coil domain-containing protein 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GCC1 Protein Structure

GRIP

GRIP: GRIP domain (716 - 760)

  • 0
  • 200
  • 400
  • 600
  • 775 a.a.
Protein Preferred Names Protein Names

GRIP and coiled-coil domain-containing protein 1

golgi coiled-coil 1

GCC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra GCC1 Q96CN9 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra GCC1 Q96CN9 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
32296183
Intra GCC1 Q96CN9 MID2 Homo sapiens Q9UJV3-2
Y2H Array
32296183
Intra GCC1 Q96CN9 NECAB2 Homo sapiens Q7Z6G3-2
Y2H Array
25416956
Intra GCC1 Q96CN9 ZNF276 Homo sapiens Q8N554-2
Y2H Array
25416956
Intra GCC1 Q96CN9 NAV1 Homo sapiens Q8NEY1-4
Y2H Array
25416956
Intra GCC1 Q96CN9 NAV1 Homo sapiens Q8NEY1-4
Validated Y2H
25416956
Intra GCC1 Q96CN9 NAV1 Homo sapiens Q8NEY1-4
Y2H Prey Pooling
25416956
Intra GCC1 Q96CN9 HDX Homo sapiens Q7Z353
Y2H Prey Pooling
32296183
Intra GCC1 Q96CN9 HDX Homo sapiens Q7Z353
Y2H Array
32296183
Intra GCC1 Q96CN9 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
25416956
Intra GCC1 Q96CN9 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
25416956
Intra GCC1 Q96CN9 ZFP90 Homo sapiens Q8TF47
Y2H Prey Pooling
32296183
Intra GCC1 Q96CN9 ZFP90 Homo sapiens Q8TF47
Y2H Array
32296183
Intra GCC1 Q96CN9 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
Intra GCC1 Q96CN9 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
Intra GCC1 Q96CN9 TP53BP2 Homo sapiens Q05BL1
Y2H Array
32296183
Intra GCC1 Q96CN9 TP53BP2 Homo sapiens Q05BL1
Y2H Prey Pooling
32296183
Intra GCC1 Q96CN9 DISC1 Homo sapiens Q9NRI5-2
Validated Y2H
32296183
Intra GCC1 Q96CN9 DISC1 Homo sapiens Q9NRI5-2
Y2H Prey Pooling
32296183
Intra GCC1 Q96CN9 DISC1 Homo sapiens Q9NRI5-2
Y2H Array
32296183
Intra GCC1 Q96CN9 RUNX1 Homo sapiens Q01196-8
Y2H Prey Pooling
32296183
Intra GCC1 Q96CN9 RUNX1 Homo sapiens Q01196-8
Y2H Array
32296183
Intra GCC1 Q96CN9 ICA1L Homo sapiens Q8NDH6-2
Y2H Array
32296183
Intra GCC1 Q96CN9 ICA1L Homo sapiens Q8NDH6-2
Y2H Prey Pooling
32296183
Intra GCC1 Q96CN9 FAM83A Homo sapiens Q86UY5
Y2H Array
32296183
Intra GCC1 Q96CN9 FAM83A Homo sapiens Q86UY5
Y2H Prey Pooling
32296183
Intra GCC1 Q96CN9 PRPF18 Homo sapiens Q99633
Validated Y2H
32296183
Intra GCC1 Q96CN9 KIAA0753 Homo sapiens Q2KHM9
Validated Y2H
25416956
Intra GCC1 Q96CN9 MEOX1 Homo sapiens P50221
Y2H Prey Pooling
32296183
Intra GCC1 Q96CN9 MEOX1 Homo sapiens P50221
Y2H Array
32296183
Intra GCC1 Q96CN9 CEP57 Homo sapiens Q86XR8
Y2H Array
25416956
Intra GCC1 Q96CN9 CEP57 Homo sapiens Q86XR8
Y2H
21516116
Intra GCC1 Q96CN9 MCRS1 Homo sapiens Q96EZ8
Y2H Pooling
19060904
Intra GCC1 Q96CN9 MCRS1 Homo sapiens Q96EZ8
Y2H Array
19060904
Intra GCC1 Q96CN9 MED4 Homo sapiens Q9NPJ6
Y2H Prey Pooling
32296183
Intra GCC1 Q96CN9 MED4 Homo sapiens Q9NPJ6
Validated Y2H
32296183
Intra GCC1 Q96CN9 MED4 Homo sapiens Q9NPJ6
Y2H Array
32296183
Intra GCC1 Q96CN9 DNAJA3 Homo sapiens Q96EY1-2
Y2H Array
25416956
Intra GCC1 Q96CN9 ATF4 Homo sapiens P18848
Y2H Array
32296183
Intra GCC1 Q96CN9 ATF4 Homo sapiens P18848
Y2H Prey Pooling
32296183
Intra GCC1 Q96CN9 ATF4 Homo sapiens P18848
Y2H Array
25416956
Intra GCC1 Q96CN9 BIRC2 Homo sapiens Q13490
Y2H Array
32296183
Intra GCC1 Q96CN9 BIRC2 Homo sapiens Q13490
Y2H Prey Pooling
32296183
Intra GCC1 Q96CN9 XIAP Homo sapiens P98170
Y2H Prey Pooling
32296183
Intra GCC1 Q96CN9 XIAP Homo sapiens P98170
Y2H Array
32296183
Intra GCC1 Q96CN9 PPP1R27 Homo sapiens Q86WC6
Y2H Array
32296183
Intra GCC1 Q96CN9 PPP1R27 Homo sapiens Q86WC6
Y2H Prey Pooling
32296183
Intra GCC1 Q96CN9 OIP5 Homo sapiens O43482
Validated Y2H
25416956
Intra GCC1 Q96CN9 OIP5 Homo sapiens O43482
Y2H Array
25416956
Intra GCC1 Q96CN9 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra GCC1 Q96CN9 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra GCC1 Q96CN9 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra GCC1 Q96CN9 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra GCC1 Q96CN9 LCA5 Homo sapiens Q86VQ0
Y2H Prey Pooling
32296183
Intra GCC1 Q96CN9 LCA5 Homo sapiens Q86VQ0
Y2H Array
32296183
Intra GCC1 Q96CN9 TRIM29 Homo sapiens Q14134
Pull Down
16189514
Intra GCC1 Q96CN9 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra GCC1 Q96CN9 CEP70 Homo sapiens Q8NHQ1
Y2H Array
25416956
Intra GCC1 Q96CN9 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Intra GCC1 Q96CN9 FBXO28 Homo sapiens Q9NVF7
Validated Y2H
32296183
Intra GCC1 Q96CN9 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
25416956
Intra GCC1 Q96CN9 PAK5 Homo sapiens Q9P286
Y2H Array
25416956
Intra GCC1 Q96CN9 PAK5 Homo sapiens Q9P286
Y2H Prey Pooling
25416956
Intra GCC1 Q96CN9 KATNAL1 Homo sapiens Q9BW62
Validated Y2H
32296183
Intra GCC1 Q96CN9 KATNAL1 Homo sapiens Q9BW62
Y2H Prey Pooling
32296183
Intra GCC1 Q96CN9 KATNAL1 Homo sapiens Q9BW62
Y2H Array
32296183
Intra GCC1 Q96CN9 ABI2 Homo sapiens Q9NYB9
Y2H Prey Pooling
25416956
Intra GCC1 Q96CN9 ABI2 Homo sapiens Q9NYB9
Y2H Array
29892012
Intra GCC1 Q96CN9 ABI2 Homo sapiens Q9NYB9
Validated Y2H
25416956
Intra GCC1 Q96CN9 FOSL1 Homo sapiens P15407
Y2H Prey Pooling
32296183
Intra GCC1 Q96CN9 FOSL1 Homo sapiens P15407
Y2H Array
32296183
Intra GCC1 Q96CN9 ZC4H2 Homo sapiens Q9NQZ6
Validated Y2H
32296183
Intra GCC1 Q96CN9 ZC4H2 Homo sapiens Q9NQZ6
Y2H Array
32296183
Intra GCC1 Q96CN9 ZC4H2 Homo sapiens Q9NQZ6
Y2H Prey Pooling
32296183
Intra GCC1 Q96CN9 FIGNL1 Homo sapiens Q6PIW4
Y2H Array
32296183
Intra GCC1 Q96CN9 FIGNL1 Homo sapiens Q6PIW4
Y2H Prey Pooling
32296183
Intra GCC1 Q96CN9 NAB2 Homo sapiens Q15742
Y2H Array
25416956
Intra GCC1 Q96CN9 NAB2 Homo sapiens Q15742
Validated Y2H
25416956
Intra GCC1 Q96CN9 C1orf94 Homo sapiens Q6P1W5
Y2H Array
25416956
Intra GCC1 Q96CN9 TRIM50 Homo sapiens Q86XT4
Y2H Prey Pooling
32296183
Intra GCC1 Q96CN9 TRIM50 Homo sapiens Q86XT4
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Charcot-Marie-Tooth Disease, Axonal, Type 2z

CMT2Z

Charcot-Marie-Tooth Disease Axonal Type 2z

Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2z

Charcot-Marie-Tooth Neuropathy, Type 2z

Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Type 2z

Charcot-Marie-Tooth Neuropathy Type 2z

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2z

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Morc2 Mutation

Charcot-Marie-Tooth Disease 2z

Charcot-Marie-Tooth Disease, Type 2z
Phencyclidine Abuse

Pcp Abuse
Maturity-Onset Diabetes Of The Young

MODY

Maturity Onset Diabetes Mellitus In Young

Mason-Type Diabetes

Mason Type Diabetes

Maturity Onset Diabetes Of The Young

Mody Syndrome

Diabetes Of The Young, Maturity-Onset
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05319 GCC1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GCC1 VGNC VGNC:41139
Bos taurus GCC1 VGNC VGNC:29280
Rattus norvegicus GCC1 RGD RGD:2319954
Felis catus GCC1 VGNC VGNC:62487
Mus musculus GCC1 MGD MGI:1921625
Macaca mulatta GCC1 VGNC VGNC:72742