2. Gene
  3. GPR119 - G protein-coupled receptor 119 Gene

GPR119 - G protein-coupled receptor 119 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GPCR2

Gene ID: 139760 | Gene type: protein coding

About GPR119

Cytogenetic location: Xq26.1 Genomic coordinates (GRCh38): X:130,379,449-130,385,674 (from NCBI)

This gene has 2 transcripts (splice variants), 176 orthologues and 18 paralogues.

Summary

This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes.[provided by RefSeq, Jan 2010]

GPR119 Products(1)

mRNA Protein Name
NM_178471.3 NP_848566.1 glucose-dependent insulinotropic receptor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence Reference Source
part of receptor complex IDA
IDA: Inferred from direct assay
23382219 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR119 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (22 - 279)

  • 0
  • 100
  • 200
  • 300
  • 335 a.a.
Protein Preferred Names Protein Names

glucose-dependent insulinotropic receptor

G-protein coupled receptor 2

GPR119 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
GPR119 Q8TDV5 ASPH Homo sapiens Q12797-6
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Diabetes Mellitus

Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-15291 MBX-2982 Agonist 98.51% Phase 2
HY-12066 GSK1292263 Agonist 99.71% Phase 2
HY-109032 Firuglipel Agonist 99.91% Phase 2
HY-15565 APD668 Agonist 99.10% Phase 1
HY-15566 APD597 Agonist 99.97% Phase 1
Pre-clinical Phase
Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-W011121 2-Oleoylglycerol Agonist ≥99.0% Unkown
HY-15564 AR 231453 Agonist 99.70% Unkown
HY-107535 AS1269574 Agonist 99.84% Unkown
HY-16673 PSN632408 Agonist 99.30% Unkown
HY-108258 PSN 375963 Agonist 99.96% Unkown
HY-146468 DPP-4/GPR119 modulator 1 Agonist / Unkown
HY-108258A PSN 375963 hydrochloride Agonist / Unkown
HY-146469 DPP-4/GPR119 modulator 2 Agonist / Unkown
HY-155553 GPR119 agonist 2 Agonist / Unkown
HY-126807 AS1907417 Agonist / Unkown
HY-12375 BMS-903452 Agonist / Unkown
HY-120637 BMS-986034 Agonist / Unkown
HY-18354 GSK1104252A Activator / Unkown
HY-172120 GPR119 agonist 3 Agonist / Unkown
HY-113653 GSK2041706A Agonist / Unkown
HY-117446 AS-1669058 Agonist / Unkown
HY-117446A AS-1669058 free base Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta GPR119 VGNC VGNC:72967
Bos taurus GPR119 VGNC VGNC:29546
Rattus norvegicus GPR119 RGD RGD:727808
Felis catus GPR119 VGNC VGNC:62672
Canis familiaris GPR119 VGNC VGNC:41394
Mus musculus GPR119 MGD MGI:2668412