2. Gene
  3. F5 - coagulation factor V Gene

F5 - coagulation factor V Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Cf5; Cf-5

Gene ID: 14067 | Gene type: protein coding

About F5

Summary

This gene encodes a glycoprotein coagulation factor that plays a critical role in the process of blood coagulation and hemostasis. The encoded protein is activated by Thrombin, to generate a heterodimer containing heavy and light chains held together by calcium ions. About half of the mice lacking the encoded protein die at an embryonic stage possible due to abnormal yolk-sac vasculature while the remaining Animals succumbed to massive hemorrhage immediately after birth. A point mutation in this gene has been shown to cause disseminated intravascular thrombosis in the perinatal period, resulting in frequent deaths of newborn mice. [provided by RefSeq, Apr 2015]

F5 Products(1)

mRNA Protein Name
NM_007976.3 NP_032002.1 coagulation factor V preproprotein
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within blood circulation IMP
IMP: Inferred from mutant phenotype
8900278 MGI
acts upstream of or within blood coagulation IDA
IDA: Inferred from direct assay
12816857 MGI
acts upstream of or within blood coagulation IMP
IMP: Inferred from mutant phenotype
8900278 MGI
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
10669158 MGI
located in platelet alpha granule IDA
IDA: Inferred from direct assay
12816857 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

coagulation factor V

activated protein C cofactor

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P0039 BIM-26226 Antagonist 99.94% Phase 1
Pre-clinical Phase
Bioactive Molecules (42)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-112698 CA-5f 99.14% Unkown
HY-W093272 Thalidomide-5,6-F Inducer 99.84% Unkown
HY-108277 Ginsenoside F5 Inducer 99.76% Unkown
HY-124421 5F-203 Inducer 99.04% Unkown
HY-W010811 Fmoc-Phe(F5)-OH 99.08% Unkown
HY-P5367 5-FAM-PMDM6 97.02% Unkown
HY-118847 Antifungal agent 86 Inhibitor / Unkown
HY-147698 ZLHQ-5f / Unkown
HY-D1410 DMTr-4'-F-5-Me-U-CED phosphoramidite / Unkown
HY-D1758 Fura-5F AM / Unkown
HY-D1779 Fura-5F pentapotassium / Unkown
HY-N8311 Goshonoside F5 Inhibitor / Unkown
HY-P2579 Dafphedyn Agonist / Unkown
HY-P4020 2F5 epitope / Unkown
HY-P4025 ELDKWA / Unkown
HY-R01575 hsa-miR-518f-5p mimic / Unkown
HY-R01575A hsa-miR-518f-5p agomir / Unkown
HY-R01604 hsa-miR-520f-5p mimic / Unkown
HY-R01604A hsa-miR-520f-5p agomir / Unkown
HY-R01684 hsa-miR-548f-5p mimic / Unkown
HY-R01684A hsa-miR-548f-5p agomir / Unkown
HY-R03052 mmu-miR-344f-5p mimic / Unkown
HY-R03052A mmu-miR-344f-5p agomir / Unkown
HY-R03177 mmu-miR-466f-5p mimic / Unkown
HY-R03177A mmu-miR-466f-5p agomir / Unkown
HY-R03468 mmu-miR-669f-5p mimic / Unkown
HY-R03468A mmu-miR-669f-5p agomir / Unkown
HY-RI01575 hsa-miR-518f-5p inhibitor / Unkown
HY-RI01575A hsa-miR-518f-5p antagomir / Unkown
HY-RI01604 hsa-miR-520f-5p inhibitor / Unkown
HY-RI01604A hsa-miR-520f-5p antagomir / Unkown
HY-RI01684 hsa-miR-548f-5p inhibitor / Unkown
HY-RI01684A hsa-miR-548f-5p antagomir / Unkown
HY-RI03052 mmu-miR-344f-5p inhibitor / Unkown
HY-RI03052A mmu-miR-344f-5p antagomir / Unkown
HY-RI03177 mmu-miR-466f-5p inhibitor / Unkown
HY-RI03177A mmu-miR-466f-5p antagomir / Unkown
HY-RI03468 mmu-miR-669f-5p inhibitor / Unkown
HY-RI03468A mmu-miR-669f-5p antagomir / Unkown
HY-RS04114 E2F5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04644 F5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS09816 OR4F5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990255 Anti-Mouse CXCL9/MIG Antibody (MIG-2F5.5) 95.00% Unkown
HY-P990221 Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens F5 NCBI NCBI:2153
Canis familiaris F5 NCBI NCBI:100685858
Macaca fascicularis F5 NCBI NCBI:102141482
Leporidae F5 NCBI
Rattus norvegicus F5 NCBI NCBI:304929
Macaca mulatta F5 NCBI NCBI:704695