Fgfr3 - fibroblast growth factor receptor 3 Gene

Mus musculus

Also known as FR3; Mfr3; sam3; CD333; Flg-2; HBGFR; Fgfr-3

Gene ID: 14184 | Gene type: protein coding

About Fgfr3

Chromosome 5: 33,879,018-33,894,412 forward strand.GRCm39:CM000998.3

This gene has 17 transcripts (splice variants), 191 orthologues, 53 paralogues and is associated with 200 phenotypes. Broad expression in lung adult (RPKM 46.), limb E14.5 (RPKM 23.9) and 21 other tissues.

Summary

This gene encodes a member of the Fibroblast Growth Factor receptor family. Members of this family are highly conserved proteins that differ from one another in their ligand affinities and tissue distribution. A representative protein consists of an extracellular region composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene may be associated with craniosynostosis and multiple types of skeletal dysplasia. A pseudogene of this gene is located on chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2011]

Fgfr3 Products(7)

mRNA	Protein	Name
NM_001359036.1	NP_001345965.1	fibroblast growth factor receptor 3 isoform 4 precursor
NM_008010.5	NP_032036.2	fibroblast growth factor receptor 3 isoform 1 precursor
NM_001205270.1	NP_001192199.1	fibroblast growth factor receptor 3 isoform 4 precursor
NM_001163215.2	NP_001156687.1	fibroblast growth factor receptor 3 isoform 1 precursor
NM_001163217.2	NP_001156689.1	fibroblast growth factor receptor 3 isoform 3 precursor
NM_001163216.2	NP_001156688.1	fibroblast growth factor receptor 3 isoform 2 precursor
NM_001359037.1	NP_001345966.1	fibroblast growth factor receptor 3 isoform 5

Fgfr3 Protein Structure

Ig_3

IgI_2_FGFR

PTKc_FGFR3

0
200
400
600
800 a.a.

Protein Preferred Names

Protein Names

fibroblast growth factor receptor 3

heparin-binding growth factor receptor

Recombinant Fgfr3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73056	FGFR-3 Protein, Mouse (HEK293, His-Fc)	Q7TSI8 (E21-Y367)	≥95%
HY-P74153	FGFR-3 Protein, Mouse (HEK293, His)	Q61851 (E21-Y367)	≥95%
HY-P77662	FGFR-3 alpha (IIIb) Protein, Mouse (HEK293, His)	E9QNJ9 (P22-V349)	≥95%

Related Agents

Approval

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10981	Lenvatinib	Inhibitor	99.75%	Yes
HY-50904	Nintedanib	Inhibitor	99.94%	Yes
HY-18708	Erdafitinib	Inhibitor	99.66%	Unkown
HY-13311	Infigratinib	Inhibitor	99.72%	Yes
HY-109099	Pemigatinib	Inhibitor	99.84%	Yes
HY-100818	Futibatinib	Inhibitor	99.65%	Unkown
HY-11106	Nintedanib esylate	Inhibitor	99.95%	Yes
HY-10981A	Lenvatinib mesylate	Inhibitor	99.86%	Yes
HY-13311A	Infigratinib phosphate	Inhibitor	99.74%	Yes

Clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13330	Fexagratinib	Inhibitor	99.85%	Phase 3
HY-50905	Dovitinib	Inhibitor	99.88%	Phase 3
HY-100019	Rogaratinib	Inhibitor	99.86%	Phase 3
HY-10207	Dovitinib lactate	Inhibitor	99.75%	Phase 3
HY-B0062	Dovitinib lactate hydrate	Inhibitor	/	Phase 3
HY-101568	Roblitinib	Inhibitor	99.74%	Phase 2
HY-13034	Gandotinib	Inhibitor	99.82%	Phase 2
HY-19981	Derazantinib	Inhibitor	99.28%	Phase 2
HY-19957	Zoligratinib	Inhibitor	99.76%	Phase 2
HY-101466A	E7090 succinate	Inhibitor	99.17%	Phase 2
HY-13304	LY2874455	Inhibitor	98.03%	Phase 1
HY-10032	PF 477736	Inhibitor	99.21%	Phase 1
HY-119367	ODM-203	Inhibitor	99.91%	Phase 1
HY-101768	PRN1371	Inhibitor	99.43%	Phase 1
HY-19983	ASP5878	Inhibitor	99.69%	Phase 1
HY-100491	H3B-6527	Inhibitor	≥98.0%	Phase 1

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99384	Vofatamab	Inhibitor	95.00%	Phase 2
HY-P99823	Recifercept		97.10%	Phase 2

Pre-clinical Phase

Bioactive Molecules (29)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12823	BLU9931	Inhibitor	99.97%	Unkown
HY-18602	FIIN-2	Inhibitor	99.32%	Unkown
HY-15599	SSR128129E	Inhibitor	99.85%	Unkown
HY-145231	FGFR2-IN-2	Inhibitor	98.25%	Unkown
HY-148779	FGFR3-IN-5	Inhibitor	99.28%	Unkown
HY-101466	E7090	Inhibitor	99.64%	Unkown
HY-131908	CPL304110	Inhibitor	99.85%	Unkown
HY-15813	FIIN-1	Inhibitor	99.11%	Unkown
HY-18603	FIIN-3	Inhibitor	99.66%	Unkown
HY-P3695	VSPPLTLGQLLS	Inhibitor	98.08%	Unkown
HY-12965	S49076	Inhibitor	99.44%	Unkown
HY-108933	JK-P3	Inhibitor	99.72%	Unkown
HY-148778	FGFR3-IN-4	Inhibitor	/	Unkown
HY-156790	FGFR3-IN-6	Inhibitor	/	Unkown
HY-147714	FGFR3-IN-2	Inhibitor	/	Unkown
HY-151903S	FGFR2/3-IN-1	Inhibitor	/	Unkown
HY-156791	FGFR3-IN-7	Inhibitor	/	Unkown
HY-142921	FGFR-IN-2	Inhibitor	/	Unkown
HY-P3695A	VSPPLTLGQLLS TFA	Inhibitor	/	Unkown
HY-155028	FGFR-IN-11	Inhibitor	/	Unkown
HY-152146	HDAC-IN-50	Inhibitor	/	Unkown
HY-150652	FGFR-IN-8	Inhibitor	/	Unkown
HY-152104	FGFR-IN-9	Inhibitor	/	Unkown
HY-147713	FGFR3-IN-1	Inhibitor	/	Unkown
HY-158248	FGFR4-IN-19	Inhibitor	/	Unkown
HY-147715	FGFR3-IN-3	Inhibitor	/	Unkown
HY-164459	AZ8010	Inhibitor	/	Unkown
HY-159503A	Segigratinib hydrochloride	Inhibitor	/	Unkown
HY-15599A	SSR128129E free acid	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fgfr3	NCBI	NCBI:2261

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