2. Gene
  3. Gapdh - glyceraldehyde-3-phosphate dehydrogenase Gene

Gapdh - glyceraldehyde-3-phosphate dehydrogenase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Gapd

Gene ID: 14433 | Gene type: protein coding

About Gapdh

Summary

This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein was originally identified as a key glycolytic Enzyme that converts D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Subsequent studies have assigned a variety of additional functions to the protein including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a Transferrin Receptor on the cell surface of macrophage. Alternative splicing results in multiple transcript variants. Many pseudogenes similar to this locus are found throughout the mouse genome. [provided by RefSeq, Jan 2014]

Gapdh Products(8)

mRNA Protein Name
NM_001289726.2 NP_001276655.1 glyceraldehyde-3-phosphate dehydrogenase isoform 1
NM_001411840.1 NP_001398769.1 glyceraldehyde-3-phosphate dehydrogenase isoform 2
NM_001411841.1 NP_001398770.1 glyceraldehyde-3-phosphate dehydrogenase isoform 3
NM_001411842.1 NP_001398771.1 glyceraldehyde-3-phosphate dehydrogenase isoform 3
NM_001411843.1 NP_001398772.1 glyceraldehyde-3-phosphate dehydrogenase isoform 3
NM_001411844.1 NP_001398773.1 glyceraldehyde-3-phosphate dehydrogenase isoform 3
NM_001411845.1 NP_001398774.1 glyceraldehyde-3-phosphate dehydrogenase isoform 3
NM_008084.4 NP_032110.1 glyceraldehyde-3-phosphate dehydrogenase isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
19903941 MGI
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IDA
IDA: Inferred from direct assay
176725 MGI
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IMP
IMP: Inferred from mutant phenotype
3796661 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19423573 MGI
Biological Process GO Annotation Evidence Reference Source
involved in canonical glycolysis IDA
IDA: Inferred from direct assay
12581789 MGI
involved in canonical glycolysis IMP
IMP: Inferred from mutant phenotype
10777777 MGI
involved in gluconeogenesis IDA
IDA: Inferred from direct assay
28258188 MGI
acts upstream of or within multicellular organism development IMP
IMP: Inferred from mutant phenotype
3796661 MGI
involved in negative regulation of translation IDA
IDA: Inferred from direct assay
23071094 MGI
Cellular Component GO Annotation Evidence Reference Source
part of GAIT complex IDA
IDA: Inferred from direct assay
23071094 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
17962088 MGI
is active in cytosol IDA
IDA: Inferred from direct assay
21347706 MGI
located in cytosol IDA
IDA: Inferred from direct assay
21413931 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
18698006 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glyceraldehyde-3-phosphate dehydrogenase

peptidyl-cysteine S-nitrosylase GAPDH

Recombinant Gapdh Proteins

Cat. No. Product Name Accession Purity
HY-P74129 GAPDH Protein, Mouse (His) P16858 (M1-E333) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-16361A Omigapil maleate Inhibitor 99.43% Phase 2
HY-147280 Misetionamide Inducer 99.49% Phase 1
Pre-clinical Phase
Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-123962 G6PD activator AG1 Activator 99.54% Unkown
HY-112758 DLin-KC2-DMA 99.88% Unkown
HY-D0849 Sodium iodoacetate Inhibitor 99.91% Unkown
HY-P2804 GAPDH, rabbit muscle 96.00% Unkown
HY-120838 Heptelidic acid Inhibitor 97.50% Unkown
HY-157395 malonyl-NAC / Unkown
HY-132126 SPHINX Inhibitor 99.87% Unkown
HY-RS05273 GAPDH Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS16270 TANGO1-S Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-123668 KM05382 Inhibitor / Unkown
HY-131921 DL-Glyceraldehyde 3-phosphate diethyl acetal barium / Unkown
HY-161668 Ru-Poma / Unkown
HY-N3247 Monomethyl kolavate Inhibitor / Unkown
HY-RS03616 DDIT4L Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS05274 GAPDHS Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS16258 Lipt1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS16276 KRT19 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gapdh NCBI NCBI:2597