E2F7 - E2F transcription factor 7 Gene

Homo sapiens

Gene ID: 144455 | Gene type: protein coding

About E2F7

Cytogenetic location: 12q21.2 Genomic coordinates (GRCh38): 12:77,021,251-77,065,569 (from NCBI)

This gene has 7 transcripts (splice variants), 211 orthologues and 7 paralogues. Broad expression in testis (RPKM 1.6), bone marrow (RPKM 1.5) and 16 other tissues.

Summary

E2F transcription factors, such as E2F7, play an essential role in the regulation of cell cycle progression (Di Stefano et al., 2003 [PubMed 14633988]).[supplied by OMIM, May 2008]

E2F7 Products(1)

mRNA	Protein	Name
NM_203394.3	NP_976328.2	transcription factor E2F7

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	22903062	GOA
enables DNA-binding transcription repressor activity	IDA IDA: Inferred from direct assay	22802528	GOA
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	22903062	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	15133492	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18202719	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	IDA IDA: Inferred from direct assay	22802528	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22802528	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22903062	GOA
involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	22903062	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

E2F7 Protein Structure

E2F_TDP

0
200
400
600
800
911 a.a.

Protein Preferred Names

Protein Names

transcription factor E2F7

E2F-7

E2F7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	E2F7	Q96AV8	E2F8	Homo sapiens	A0AVK6	Anti Tag CoIP	18202719
Intra	E2F7	Q96AV8	E2F7	Homo sapiens	Q96AV8	Anti Tag CoIP	15133492
Intra	E2F7	Q96AV8	E2F7	Homo sapiens	Q96AV8	Pull Down	15133492

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Retinal Cancer

Malignant Neoplasm Of Retina	Retinal Neoplasms
Malignant Retinal Neoplasm	Malignant Tumor Of Retina
Neoplasm Of Retina	Retinal Tumor
Retinal Neoplasm	Cancer Of The Retina
Malignant Retinal Tumour	Malignant Tumour Of Retina
Primary Malignant Neoplasm Of Retina

Bilateral Retinoblastoma

Soft Palate Cancer

Malignant Tumor Of Soft Palate	Malignant Tumor Of The Soft Palate
Palate Cancer Soft Palate

Familial Retinoblastoma

Hereditary Retinoblastoma

Retinoblastoma

Ocular Cancer

Eye Neoplasm	Eye Carcinoma
Eye Cancer	Eye Neoplasms
Malignant Eye Neoplasm	Neoplasm Of Eye
Neoplasm Of Eye Proper	Ocular Tumor
Carcinoma Of Eye	Ocular Carcinoma
Malignant Tumor Of Eye

Retinal Disease

Retinal Diseases	Retinal Disorder
Retinal Disorders

Eye Disease

Eye Diseases	Abnormality Of The Eye
Toxoplasma Oculopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04116	E2F7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	E2F7	MGD	MGI:1289147
Canis familiaris	E2F7	VGNC	VGNC:40169
Felis catus	E2F7	VGNC	VGNC:61698
Bos taurus	E2F7	VGNC	VGNC:28291
Macaca mulatta	E2F7	VGNC	VGNC:71891
Rattus norvegicus	E2F7	RGD	RGD:1310258

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