E2F8 - E2F transcription factor 8 Gene

Homo sapiens

Also known as E2F-8

Gene ID: 79733 | Gene type: protein coding

About E2F8

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:19,224,063-19,241,655 (from NCBI)

This gene has 5 transcripts (splice variants), 195 orthologues and 7 paralogues. Broad expression in bone marrow (RPKM 4.6), lymph node (RPKM 3.5) and 14 other tissues.

Summary

This gene encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the nucleus divides at the proper time. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012]

E2F8 Products(3)

mRNA	Protein	Name
NM_001256371.2	NP_001243300.1	transcription factor E2F8
NM_001256372.1	NP_001243301.1	transcription factor E2F8
NM_024680.4	NP_078956.2	transcription factor E2F8

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	22903062	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	16179649	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16179649	GOA
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	22903062	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18202719	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16179649	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22903062	GOA
involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	22903062	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

E2F8 Protein Structure

E2F_TDP

0
200
400
600
800
867 a.a.

Protein Preferred Names

Protein Names

transcription factor E2F8

E2F family member 8

Related Diseases

Diseases

Alias

Bilateral Retinoblastoma

Retinal Cancer

Malignant Neoplasm Of Retina	Retinal Neoplasms
Malignant Retinal Neoplasm	Malignant Tumor Of Retina
Neoplasm Of Retina	Retinal Tumor
Retinal Neoplasm	Cancer Of The Retina
Malignant Retinal Tumour	Malignant Tumour Of Retina
Primary Malignant Neoplasm Of Retina

Soft Palate Cancer

Malignant Tumor Of Soft Palate	Malignant Tumor Of The Soft Palate
Palate Cancer Soft Palate

Familial Retinoblastoma

Hereditary Retinoblastoma

Retinoblastoma

Ocular Cancer

Eye Neoplasm	Eye Carcinoma
Eye Cancer	Eye Neoplasms
Malignant Eye Neoplasm	Neoplasm Of Eye
Neoplasm Of Eye Proper	Ocular Tumor
Carcinoma Of Eye	Ocular Carcinoma
Malignant Tumor Of Eye

Retinal Disease

Retinal Diseases	Retinal Disorder
Retinal Disorders

Eye Disease

Eye Diseases	Abnormality Of The Eye
Toxoplasma Oculopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04117	E2F8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	E2F8	VGNC	VGNC:71900
Canis familiaris	E2F8	VGNC	VGNC:40170
Felis catus	E2F8	VGNC	VGNC:61699
Rattus norvegicus	E2F8	RGD	RGD:1308091
Bos taurus	E2F8	VGNC	VGNC:28292
Mus musculus	E2F8	MGD	MGI:1922038

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