ADRA1D - adrenoceptor alpha 1D Gene

Homo sapiens

Also known as DAR; ADRA1; ADRA1A; ADRA1R; ALPHA1; dJ779E11.2

Gene ID: 146 | Gene type: protein coding

About ADRA1D

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:4,220,630-4,249,287 (from NCBI)

This gene has 2 transcripts (splice variants), 196 orthologues and 18 paralogues. Biased expression in prostate (RPKM 2.3), spleen (RPKM 0.8) and 10 other tissues.

Summary

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008]

ADRA1D Products(1)

mRNA	Protein	Name
NM_000678.4	NP_000669.1	alpha-1D adrenergic receptor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	14645668	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16533813	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADRA1D Protein Structure

7tm_1

0
100
200
300
400
500
572 a.a.

Protein Preferred Names

Protein Names

alpha-1D adrenergic receptor

adrenergic, alpha -1D-, receptor

ADRA1D Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	ADRA1D	P25100	Snta1	Mus musculus	Q61234	Anti Tag CoIP	16533813
Intra	ADRA1D	P25100	SCRIB	Homo sapiens	Q14160	TAP	26617989
Intra	ADRA1D	P25100	SCRIB	Homo sapiens	Q14160	Pull Down	26617989
Intra	ADRA1D	P25100	SCRIB	Homo sapiens	Q14160	Confocal	26617989
Intra	ADRA1D	P25100	SCRIB	Homo sapiens	Q14160	Pull Down	27382054
Intra	ADRA1D	P25100	SNTB2	Homo sapiens	Q13425	TAP	26617989
Intra	ADRA1D	P25100	SNTB2	Homo sapiens	Q13425	TAP	18468998
Intra	ADRA1D	P25100	SNTA1	Homo sapiens	Q13424	Pull Down	26617989
Intra	ADRA1D	P25100	SNTB2	Homo sapiens	Q13425	Pull Down	27382054
Intra	ADRA1D	P25100	SNTB2	Homo sapiens	Q13425	TAP	21115837
Intra	ADRA1D	P25100	SNTA1	Homo sapiens	Q13424	Confocal	26617989
Intra	ADRA1D	P25100	SNTA1	Homo sapiens	Q13424	TAP	26617989
Intra	ADRA1D	P25100	SNTB2	Homo sapiens	Q13425	Pull Down	18468998
Intra	ADRA1D	P25100	SNTA1	Homo sapiens	Q13424	Pull Down	18468998
Intra	ADRA1D	P25100	SNTA1	Homo sapiens	Q13424	Pull Down	27382054

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ureterolithiasis

Calculus Of Ureter	Ureteric Stone
Ureteral Calculi	Ureteric Calculus
Stone In The Ureter	Ureter Calculi
Ureteral Calculus Or Stone	Ureterolith
Ureterolithiasis Nos

Perianal Hematoma

External Thrombosed Haemorrhoids

Thrombosed External Hemorrhoids

Gastroparesis

Gastroparesis Syndrome	Delayed Gastric Emptying
Gastric Atonia	Gastroparalysis

Prostatic Hypertrophy

Benign Prostatic Hypertrophy

Prostatic Hyperplasia

Schizophrenia 19

SCZD19	Schizophrenia 19 With Or Without An Affective Disorder
Schizophrenia 19, Susceptibility To	{Schizophrenia 19, Susceptibility To}

Impotence

Erectile Dysfunction	Sexual Impotence
Erectile Dysfunction Adverse Event

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Urethral Stricture

Ankylurethria	Urethral Stenosis
Urethral Contracture	Urethral Obstruction
Meatal Stenosis Nos	Constriction Of Urethra
Contraction Of Urethra	Stricture Of Urinary Meatus
Urethral Obliteration	Urethral Narrowing
Pinpoint Meatus	Pinhole Meatus Nos
Urethral Occlusion

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-135270	ADRA1D receptor antagonist 1	Antagonist	98.13%	Unkown
HY-148252	ADRA1D receptor antagonist 1 free base	Antagonist	/	Unkown
HY-RS00410	ADRA1D Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ADRA1D	RGD	RGD:62064
Felis catus	ADRA1D	VGNC	VGNC:59655
Canis familiaris	ADRA1D	VGNC	VGNC:37674
Bos taurus	ADRA1D	VGNC	VGNC:25695
Mus musculus	ADRA1D	MGD	MGI:106673
Macaca mulatta	ADRA1D	VGNC	VGNC:107732

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