ADRA1D receptor antagonist 1

Name: ADRA1D receptor antagonist 1
Brand: MedChemExpress
SKU: HY-135270
Rating: 4.5 (1 reviews)

Cat. No.: HY-135270 Purity: 98.13%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

ADRA1D receptor antagonist 1 is a potent, selective and orally active α_1D adrenoceptor antagonist, with a K_i of 1.6 nM.

For research use only. We do not sell to patients.

ADRA1D receptor antagonist 1 Chemical Structure

CAS No. : 1191908-14-1

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 528	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 528	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 800	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1550	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2400	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 3600	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of ADRA1D receptor antagonist 1:

ADRA1D receptor antagonist 1 free base Get quote

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α adrenergic receptor β adrenergic receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

ADRA1D receptor antagonist 1 is a potent, selective and orally active α_1D adrenoceptor antagonist, with a K_i of 1.6 nM^[1].

IC₅₀ & Target

Ki: 1.6 nM (α_1D adrenoceptor)^[1]

In Vitro

ADRA1D receptor antagonist 1 shows low hERG inhibition^[1].
ADRA1D receptor antagonist 1 exhibits higher selectivity for α1D-AR over α1A- and α1B-ARs ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ADRA1D receptor antagonist 1 (4.4 µg/kg; i.v.) dose-dependently decreases the non-voiding bladder contractions during the urinary storage phase in rats with BOO^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rat with bladder outlet obstruction (BOO)^[1]
Dosage:	4.4 µg/kg
Administration:	Intravenous injection
Result:	Dose-dependently decreased the non-voiding bladder contractions during urinary storage phase in rats with BOO.

Molecular Weight

337.20

Formula

C₁₅H₁₄Cl₂N₄O

CAS No.

1191908-14-1

Appearance

Solid

Color

Yellow to brown

SMILES

O=C(C1=CC(Cl)=CN([C@@H](C2=CC=CC(C#N)=C2)C)C1=N)N.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (296.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9656 mL	14.8280 mL	29.6560 mL
5 mM	0.5931 mL	2.9656 mL	5.9312 mL
10 mM	0.2966 mL	1.4828 mL	2.9656 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.13%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (248 KB) HNMR (254 KB) RP-HPLC (271 KB) MS (68 KB)

Handling Instructions (2659 KB)

References

[1]. Sakauchi N, et al. Discovery of 5-Chloro-1-(5-chloro-2-(methylsulfonyl)benzyl)-2-imino-1,2-dihydropyridine-3-carboxamide (TAK-259) as a Novel, Selective, and Orally Active α1D Adrenoceptor Antagonist with Antiurinary Frequency Effects: Reducing Human Ethe [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9656 mL	14.8280 mL	29.6560 mL	74.1400 mL
	5 mM	0.5931 mL	2.9656 mL	5.9312 mL	14.8280 mL
	10 mM	0.2966 mL	1.4828 mL	2.9656 mL	7.4140 mL
	15 mM	0.1977 mL	0.9885 mL	1.9771 mL	4.9427 mL
	20 mM	0.1483 mL	0.7414 mL	1.4828 mL	3.7070 mL
	25 mM	0.1186 mL	0.5931 mL	1.1862 mL	2.9656 mL
	30 mM	0.0989 mL	0.4943 mL	0.9885 mL	2.4713 mL
	40 mM	0.0741 mL	0.3707 mL	0.7414 mL	1.8535 mL
	50 mM	0.0593 mL	0.2966 mL	0.5931 mL	1.4828 mL
	60 mM	0.0494 mL	0.2471 mL	0.4943 mL	1.2357 mL
	80 mM	0.0371 mL	0.1853 mL	0.3707 mL	0.9267 mL
	100 mM	0.0297 mL	0.1483 mL	0.2966 mL	0.7414 mL