2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. ADRA1D receptor antagonist 1

ADRA1D receptor antagonist 1 is a potent, selective and orally active α1D adrenoceptor antagonist, with a Ki of 1.6 nM.

For research use only. We do not sell to patients.

ADRA1D receptor antagonist 1 Chemical Structure

ADRA1D receptor antagonist 1 Chemical Structure

CAS No. : 1191908-14-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 528 In-stock
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10 mM * 1 mL in DMSO USD 528 In-stock
Solid
1 mg USD 192 In-stock
5 mg USD 480 In-stock
10 mg USD 800 In-stock
25 mg USD 1550 In-stock
50 mg USD 2400 In-stock
100 mg USD 3600 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of ADRA1D receptor antagonist 1:

ADRA1D receptor antagonist 1 Related Antibodies

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Description

ADRA1D receptor antagonist 1 is a potent, selective and orally active α1D adrenoceptor antagonist, with a Ki of 1.6 nM[1].

IC50 & Target

Ki: 1.6 nM (α1D adrenoceptor)[1]
In Vitro

ADRA1D receptor antagonist 1 shows low hERG inhibition[1].
ADRA1D receptor antagonist 1 exhibits higher selectivity for α1D-AR over α1A- and α1B-ARs [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ADRA1D receptor antagonist 1 Related Antibodies
In Vivo

ADRA1D receptor antagonist 1 (4.4 µg/kg; i.v.) dose-dependently decreases the non-voiding bladder contractions during the urinary storage phase in rats with BOO[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat with bladder outlet obstruction (BOO)[1]
Dosage: 4.4 µg/kg
Administration: Intravenous injection
Result: Dose-dependently decreased the non-voiding bladder contractions during urinary storage phase in rats with BOO.
Molecular Weight

337.20

Formula

C15H14Cl2N4O
CAS No.
Appearance

Solid

Color

Yellow to brown

SMILES

O=C(C1=CC(Cl)=CN([C@@H](C2=CC=CC(C#N)=C2)C)C1=N)N.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (296.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9656 mL 14.8280 mL 29.6560 mL
5 mM 0.5931 mL 2.9656 mL 5.9312 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9656 mL 14.8280 mL 29.6560 mL 74.1400 mL
5 mM 0.5931 mL 2.9656 mL 5.9312 mL 14.8280 mL
10 mM 0.2966 mL 1.4828 mL 2.9656 mL 7.4140 mL
15 mM 0.1977 mL 0.9885 mL 1.9771 mL 4.9427 mL
20 mM 0.1483 mL 0.7414 mL 1.4828 mL 3.7070 mL
25 mM 0.1186 mL 0.5931 mL 1.1862 mL 2.9656 mL
30 mM 0.0989 mL 0.4943 mL 0.9885 mL 2.4713 mL
40 mM 0.0741 mL 0.3707 mL 0.7414 mL 1.8535 mL
50 mM 0.0593 mL 0.2966 mL 0.5931 mL 1.4828 mL
60 mM 0.0494 mL 0.2471 mL 0.4943 mL 1.2357 mL
80 mM 0.0371 mL 0.1853 mL 0.3707 mL 0.9267 mL
100 mM 0.0297 mL 0.1483 mL 0.2966 mL 0.7414 mL
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ADRA1D receptor antagonist 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ADRA1D receptor antagonist 11191908-14-1Adrenergic ReceptorBeta Receptorbladderoutletobstructionα(1D)-adrenoceptorInhibitorinhibitorinhibit

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