CD300LF - CD300 molecule like family member f Gene

Homo sapiens

Also known as CLM1; NKIR; CLM-1; IREM1; LMIR3; CD300f; IREM-1; IgSF13

Gene ID: 146722 | Gene type: protein coding

About CD300LF

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:74,694,317-74,712,923 (from NCBI)

This gene has 10 transcripts (splice variants), 288 orthologues and 13 paralogues. Biased expression in spleen (RPKM 9.3), bone marrow (RPKM 8.2) and 10 other tissues.

Summary

This gene encodes a member of the CD300 protein family. Members of this family are cell surface glycoproteins with a single IgV-like extracellular domain, and are involved in the regulation of immune response. The encoded protein is an inhibitory receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

CD300LF Products(7)

mRNA	Protein	Name
NM_001289082.2	NP_001276011.1	CMRF35-like molecule 1 isoform 2
NM_001289083.2	NP_001276012.1	CMRF35-like molecule 1 isoform 3 precursor
NM_001289084.2	NP_001276013.1	CMRF35-like molecule 1 isoform 4
NM_001289085.2	NP_001276014.1	CMRF35-like molecule 1 isoform 5
NM_001289086.2	NP_001276015.1	CMRF35-like molecule 1 isoform 6
NM_001289087.2	NP_001276016.1	CMRF35-like molecule 1 isoform 7 precursor
NM_139018.5	NP_620587.2	CMRF35-like molecule 1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables ceramide binding	IDA IDA: Inferred from direct assay	24035150	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	20959446	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20959446	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in TRIF-dependent toll-like receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	22043923	GOA
involved in negative regulation of MyD88-dependent toll-like receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	22043923	GOA
involved in negative regulation of mast cell activation	IDA IDA: Inferred from direct assay	24035150	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD300LF Protein Structure

V-set

SIT

0
100
200
290 a.a.

Protein Preferred Names

Protein Names

CMRF35-like molecule 1

CD300 antigen-like family member F

CD300LF Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CD300LF	Q8TDQ1	CD300LB	Homo sapiens	A8K4G0	Anti Tag CoIP	20959446
Intra	CD300LF	Q8TDQ1	CD300LF	Homo sapiens	Q8TDQ1	Anti Tag CoIP	22291008
Intra	CD300LF	Q8TDQ1	CD300LF	Homo sapiens	Q8TDQ1	Anti Tag CoIP	29051512
Intra	CD300LF	Q8TDQ1	PTPN6	Homo sapiens	P29350	CoIP	15549731
Intra	CD300LF	Q8TDQ1	CD300LF	Homo sapiens	Q8TDQ1	Anti Tag CoIP	20959446
Intra	CD300LF	Q8TDQ1	CD300LD	Homo sapiens	Q6UXZ3	Anti Tag CoIP	22291008

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD300LF Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71595	CD300LF Protein, Human (His)	Q8TDQ1-1 (T20-S156)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02231	CD300LF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CD300LF	VGNC	VGNC:70910
Mus musculus	CD300LF	MGD	MGI:2442359
Rattus norvegicus	CD300LF	RGD	RGD:1309733
Felis catus	CD300LF	VGNC	VGNC:60611
Others	CD300LF	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.