CSTA - cystatin A Gene

Homo sapiens

Also known as AREI; PSS4; STF1; STFA

Gene ID: 1475 | Gene type: protein coding

About CSTA

Cytogenetic location: 3q21.1 Genomic coordinates (GRCh38): 3:122,325,248-122,341,969 (from NCBI)

This gene has 2 transcripts (splice variants), 208 orthologues, 1 paralogue and is associated with 4 phenotypes. Biased expression in esophagus (RPKM 1149.9), skin (RPKM 100.5) and 1 other tissue.

Summary

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine Protease Inhibitors, while Others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine Protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for Cancer. [provided by RefSeq, Jul 2008]

CSTA Products(1)

mRNA	Protein	Name
NM_005213.4	NP_005204.1	cystatin-A

CSTA Protein Structure

Cystatin

0
98 a.a.

Protein Preferred Names

Protein Names

cystatin-A

cystatin A (stefin A)

Recombinant CSTA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7868	Cystatin A/CSTA Protein, Human (His)	P01040 (I2-F98)	≥95%

Related Diseases

Diseases

Alias

Peeling Skin Syndrome 4

PSS4	Arei
Exfoliative Ichthyosis, Autosomal Recessive	Ichthyosis Bullosa Of Siemens-Like
Ichthyosis, Exfoliative, Autosomal Recessive	Exfoliative Ichthyosis Autosomal Recessive Ibs-Like
Ichthyosis, Exfoliative, Autosomal Recessive, Ichthyosis Bullosa Of Siemens-Like	Skin, Peeling, Syndrome, Type 4
Exfoliative Ichthyosis, Autosomal Recessive, Ichthyosis Bullosa Of Siemens-Like

Peeling Skin Syndrome 2

Acral Peeling Skin Syndrome	Peeling Skin Syndrome, Acral Type
Apss	PSS2
Acral Pss	Acral Deciduous Skin
Localized Pss	Localized Deciduous Skin
Peeling Skin Syndrome Type A	Skin, Peeling, Syndrome, Type 2

Exfoliative Ichthyosis

Ichthyosis Exfoliativa

Autosomal Recessive Exfoliative Ichthyosis

Peeling Skin Syndrome

Deciduous Skin	Familial Continuous Skin Peeling Syndrome
Idiopathic Deciduous Skin	Keratosis Exfoliativa Congenita
Pss	Peeling Skin Disease
Skin Peeling Syndrome	Familial Continuous Skin Peeling
Keratolysis Exfoliativa Congenita	Exfoliation Syndrome
Keratolysis Exfoliativa

Ichthyosis Bullosa Of Siemens

IBS	Ichthyosis, Bullous Type
Bullous Type Of Ichthyosis	Ichthyosis Bullous Type

Ichthyosis

Ichthyoses	Non-Syndromic Ichthyosis
Congenital Ichthyosis

Cerebral Amyloid Angiopathy, Cst3-Related

Cerebral Amyloid Angiopathy	Hereditary Cerebral Hemorrhage With Amyloidosis
Hchwa	Hereditary Cystatin C Amyloid Angiopathy
Cerebral Amyloid Angiopathy, Familial	Amyloidosis, Cerebroarterial, Icelandic Type
Amyloidosis Vi	Cerebral Hemorrhage, Hereditary, With Amyloidosis
Cst3-Related Cerebral Amyloid Angiopathy	Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant
Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant	Caa, Familial
Cerebral Amyloid Angiopathy, Genetic	Acys Amyloidosis
Cst3-Related Amyloidosis	Cystatin Amyloidosis
Hchwa, Icelandic Type	Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type
Amyloidosis 6	AMYL6
Acys	Caa
Cerebral Amyloid Angiopathy Cst3-Related	Cerebroarterial Amyloidosis Icelandic Type
Cystatin C Amyloidosis	Hccaa
Hchwai	Hchwa-I
Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type	Cerebral Amyloid Angiopathy Familial
Angiopathy, Amyloid, Cerebral, Cst3-Related	Hereditary Cerebral Amyloid Angiopathy, Icelandic Type
Familial Cerebral Amyloid Angiopathy	Cerebral Amyloid Angiopathy, Hereditary

Psoriasis

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03271	CSTA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CSTA	VGNC	VGNC:97176
Rattus norvegicus	CSTA	RGD	RGD:1309603
Canis familiaris	CSTA	VGNC	VGNC:39681
Bos taurus	CSTA	VGNC	VGNC:27779
Macaca mulatta	CSTA	VGNC	VGNC:71533
Others	CSTA	NCBI

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