CSTA - cystatin A Gene

Homo sapiens

Also known as AREI; PSS4; STF1; STFA

Gene ID: 1475 | Gene type: protein coding

About CSTA

Cytogenetic location: 3q21.1 Genomic coordinates (GRCh38): 3:122,325,248-122,341,969 (from NCBI)

This gene has 2 transcripts (splice variants), 208 orthologues, 1 paralogue and is associated with 4 phenotypes. Biased expression in esophagus (RPKM 1149.9), skin (RPKM 100.5) and 1 other tissue.

Summary

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine Protease Inhibitors, while Others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for Cancer. [provided by RefSeq, Jul 2008]

CSTA Products(1)

mRNA	Protein	Name
NM_005213.4	NP_005204.1	cystatin-A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type endopeptidase inhibitor activity	IDA IDA: Inferred from direct assay	3488317	GOA
enables protease binding	IPI IPI: Inferred from physical interaction	6203523	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11152132	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	21944047	GOA
involved in keratinocyte differentiation	IDA IDA: Inferred from direct assay	10908733	GOA
involved in negative regulation of peptidase activity	IDA IDA: Inferred from direct assay	6203523	GOA
involved in negative regulation of proteolysis	IDA IDA: Inferred from direct assay	3488317	GOA
involved in peptide cross-linking	IDA IDA: Inferred from direct assay	10908733	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cornified envelope	IDA IDA: Inferred from direct assay	10908733	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	21944047	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	3488317	GOA
part of peptidase inhibitor complex	IPI IPI: Inferred from physical interaction	20860624	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSTA Protein Structure

Cystatin

0
98 a.a.

Protein Preferred Names

Protein Names

cystatin-A

cystatin A (stefin A)

CSTA Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CSTA	P01040	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	CSTA	P01040	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	CSTA	P01040	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	CSTA	P01040	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	CSTA	P01040	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	CSTA	P01040	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	CSTA	P01040	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	CSTA	P01040	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	CSTA	P01040	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	CSTA	P01040	CTSB	Homo sapiens	P07858	Anti Tag CoIP	33961781
Intra	CSTA	P01040	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	CSTA	P01040	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	CSTA	P01040	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Cross	CSTA	P01040	papa1_carpa	Carica papaya	P00784	Fluorescence	11152132

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CSTA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7868	Cystatin A/CSTA Protein, Human (His)	P01040 (I2-F98)	≥95%

Related Diseases

Diseases

Alias

Peeling Skin Syndrome 4

PSS4	Arei
Exfoliative Ichthyosis, Autosomal Recessive	Ichthyosis Bullosa Of Siemens-Like
Ichthyosis, Exfoliative, Autosomal Recessive	Exfoliative Ichthyosis Autosomal Recessive Ibs-Like
Ichthyosis, Exfoliative, Autosomal Recessive, Ichthyosis Bullosa Of Siemens-Like	Skin, Peeling, Syndrome, Type 4
Exfoliative Ichthyosis, Autosomal Recessive, Ichthyosis Bullosa Of Siemens-Like

Peeling Skin Syndrome 2

Acral Peeling Skin Syndrome	Peeling Skin Syndrome, Acral Type
Apss	PSS2
Acral Pss	Acral Deciduous Skin
Localized Pss	Localized Deciduous Skin
Peeling Skin Syndrome Type A	Skin, Peeling, Syndrome, Type 2

Exfoliative Ichthyosis

Ichthyosis Exfoliativa

Autosomal Recessive Exfoliative Ichthyosis

Peeling Skin Syndrome

Deciduous Skin	Familial Continuous Skin Peeling Syndrome
Idiopathic Deciduous Skin	Keratosis Exfoliativa Congenita
Pss	Peeling Skin Disease
Skin Peeling Syndrome	Familial Continuous Skin Peeling
Keratolysis Exfoliativa Congenita	Exfoliation Syndrome
Keratolysis Exfoliativa

Ichthyosis Bullosa Of Siemens

IBS	Ichthyosis, Bullous Type
Bullous Type Of Ichthyosis	Ichthyosis Bullous Type

Ichthyosis

Ichthyoses	Non-Syndromic Ichthyosis
Congenital Ichthyosis

Cerebral Amyloid Angiopathy, Cst3-Related

Cerebral Amyloid Angiopathy	Hereditary Cerebral Hemorrhage With Amyloidosis
Hchwa	Hereditary Cystatin C Amyloid Angiopathy
Cerebral Amyloid Angiopathy, Familial	Amyloidosis, Cerebroarterial, Icelandic Type
Amyloidosis Vi	Cerebral Hemorrhage, Hereditary, With Amyloidosis
Cst3-Related Cerebral Amyloid Angiopathy	Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant
Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant	Caa, Familial
Cerebral Amyloid Angiopathy, Genetic	Acys Amyloidosis
Cst3-Related Amyloidosis	Cystatin Amyloidosis
Hchwa, Icelandic Type	Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type
Amyloidosis 6	AMYL6
Acys	Caa
Cerebral Amyloid Angiopathy Cst3-Related	Cerebroarterial Amyloidosis Icelandic Type
Cystatin C Amyloidosis	Hccaa
Hchwai	Hchwa-I
Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type	Cerebral Amyloid Angiopathy Familial
Angiopathy, Amyloid, Cerebral, Cst3-Related	Hereditary Cerebral Amyloid Angiopathy, Icelandic Type
Familial Cerebral Amyloid Angiopathy	Cerebral Amyloid Angiopathy, Hereditary

Psoriasis

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03271	CSTA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CSTA	VGNC	VGNC:97176
Rattus norvegicus	CSTA	RGD	RGD:1309603
Canis familiaris	CSTA	VGNC	VGNC:39681
Bos taurus	CSTA	VGNC	VGNC:27779
Macaca mulatta	CSTA	VGNC	VGNC:71533
Others	CSTA	NCBI

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