HIPK4 - homeodomain interacting protein kinase 4 Gene

Homo sapiens

Gene ID: 147746 | Gene type: protein coding

About HIPK4

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:40,379,271-40,390,181 (from NCBI)

This gene has 1 transcript (splice variant), 155 orthologues and 12 paralogues. Restricted expression toward testis (RPKM 7.8).

Summary

This gene encodes a member of the homeodomain interacting protein kinase (HIPK) family of proteins. While Other members of this family are found throughout vertebrates, this member is present only in mammals. Compared to Other members of this family, the encoded protein lacks a nuclear localization signal and a C-terminal autoinhibitory domain. The encoded protein exhibits kinase activity and may phosphorylate the tumor suppressor protein p53. [provided by RefSeq, Jul 2016]

HIPK4 Products(1)

mRNA	Protein	Name
NM_144685.5	NP_653286.2	homeodomain-interacting protein kinase 4

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22939624	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HIPK4 Protein Structure

Pkinase

0
100
200
300
400
500
616 a.a.

Protein Preferred Names

Protein Names

homeodomain-interacting protein kinase 4

HIPK4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HIPK4	Q8NE63	HSP90AB1	Homo sapiens	P08238	Pull Down	32707033
Intra	HIPK4	Q8NE63	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	HIPK4	Q8NE63	APPBP2	Homo sapiens	Q92624	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Adenosquamous Lung Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06184	HIPK4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HIPK4	MGD	MGI:2685008
Rattus norvegicus	HIPK4	RGD	RGD:1307541
Macaca mulatta	HIPK4	VGNC	VGNC:73421
Bos taurus	HIPK4	VGNC	VGNC:29861
Felis catus	HIPK4	VGNC	VGNC:62821
Others	HIPK4	NCBI

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