ARL6IP6 - ADP ribosylation factor like GTPase 6 interacting protein 6 Gene

Homo sapiens

Also known as AIP6; AIP-6; PFAAP1

Gene ID: 151188 | Gene type: protein coding

About ARL6IP6

Cytogenetic location: 2q23.3 Genomic coordinates (GRCh38): 2:152,717,648-152,762,396 (from NCBI)

This gene has 23 transcripts (splice variants), 176 orthologues and is associated with 1 phenotype. Ubiquitous expression in placenta (RPKM 7.1), bone marrow (RPKM 6.2) and 25 other tissues.

Summary

Predicted to be located in nuclear inner membrane. [provided by Alliance of Genome Resources, Apr 2022]

ARL6IP6 Products(3)

mRNA	Protein	Name
NM_001350068.2	NP_001336997.1	ADP-ribosylation factor-like protein 6-interacting protein 6 isoform b
NM_001371972.1	NP_001358901.1	ADP-ribosylation factor-like protein 6-interacting protein 6 isoform c
NM_152522.7	NP_689735.1	ADP-ribosylation factor-like protein 6-interacting protein 6 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ADP-ribosylation factor-like protein 6-interacting protein 6

ADP-ribosylation factor GTPase 6 interacting protein 6

ARL6IP6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ARL6IP6	Q8N6S5	TMEM80	Homo sapiens	Q96HE8	Validated Y2H	32296183
Intra	ARL6IP6	Q8N6S5	TMEM80	Homo sapiens	Q96HE8	Y2H Prey Pooling	32296183
Intra	ARL6IP6	Q8N6S5	TMEM80	Homo sapiens	Q96HE8	Y2H Array	32296183
Intra	ARL6IP6	Q8N6S5	GPR61	Homo sapiens	Q9BZJ8	Validated Y2H	32296183
Intra	ARL6IP6	Q8N6S5	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	ARL6IP6	Q8N6S5	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	ARL6IP6	Q8N6S5	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	ARL6IP6	Q8N6S5	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	ARL6IP6	Q8N6S5	TBXA2R	Homo sapiens	Q0VAB0	Y2H Prey Pooling	32296183
Intra	ARL6IP6	Q8N6S5	TBXA2R	Homo sapiens	Q0VAB0	Y2H Array	32296183
Intra	ARL6IP6	Q8N6S5	CMTM2	Homo sapiens	Q8TAZ6	Y2H Array	32296183
Intra	ARL6IP6	Q8N6S5	CMTM2	Homo sapiens	Q8TAZ6	Validated Y2H	32296183
Intra	ARL6IP6	Q8N6S5	CMTM2	Homo sapiens	Q8TAZ6	Y2H Prey Pooling	32296183
Intra	ARL6IP6	Q8N6S5	TMEM86B	Homo sapiens	Q8N661	Y2H Prey Pooling	32296183
Intra	ARL6IP6	Q8N6S5	TMEM86B	Homo sapiens	Q8N661	Y2H Array	32296183
Intra	ARL6IP6	Q8N6S5	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	ARL6IP6	Q8N6S5	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	ARL6IP6	Q8N6S5	SLC10A1	Homo sapiens	Q14973	Y2H Array	32296183
Intra	ARL6IP6	Q8N6S5	SLC10A1	Homo sapiens	Q14973	Y2H Prey Pooling	32296183
Intra	ARL6IP6	Q8N6S5	TIMMDC1	Homo sapiens	Q9NPL8	Y2H Prey Pooling	32296183
Intra	ARL6IP6	Q8N6S5	TIMMDC1	Homo sapiens	Q9NPL8	Validated Y2H	32296183
Intra	ARL6IP6	Q8N6S5	TMEM205	Homo sapiens	Q6UW68	Y2H Prey Pooling	32296183
Intra	ARL6IP6	Q8N6S5	TMEM205	Homo sapiens	Q6UW68	Y2H Array	32296183
Intra	ARL6IP6	Q8N6S5	MGST3	Homo sapiens	O14880	Y2H Prey Pooling	32296183
Intra	ARL6IP6	Q8N6S5	MGST3	Homo sapiens	O14880	Y2H Array	32296183
Intra	ARL6IP6	Q8N6S5	RUSF1	Homo sapiens	Q96GQ5	Y2H Prey Pooling	32296183
Intra	ARL6IP6	Q8N6S5	RUSF1	Homo sapiens	Q96GQ5	Y2H Array	32296183
Intra	ARL6IP6	Q8N6S5	RUSF1	Homo sapiens	Q96GQ5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ARL6IP6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76730	ARL6IP6 Protein, Human (HEK293, Fc)	Q8N6S5/NP_689735.1 (M1-S110)	≥95%

Related Diseases

Diseases

Alias

Cutis Marmorata Telangiectatica Congenita

CMTC	Hereditary Cutis Marmorata Telangiectatica Congenita
Van Lohuizen Syndrome

Mongolian Spot

Mongolian Macula

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00997	ARL6IP6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ARL6IP6	VGNC	VGNC:38121
Rattus norvegicus	ARL6IP6	RGD	RGD:1564819
Felis catus	ARL6IP6	VGNC	VGNC:107488
Macaca mulatta	ARL6IP6	VGNC	VGNC:104510
Mus musculus	ARL6IP6	MGD	MGI:1929507
Bos taurus	ARL6IP6	VGNC	VGNC:26152
Others	ARL6IP6	NCBI

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