2. Gene
  3. Hmgcr - 3-hydroxy-3-methylglutaryl-Coenzyme A reductase Gene

Hmgcr - 3-hydroxy-3-methylglutaryl-Coenzyme A reductase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Red; HMG-CoAR

Gene ID: 15357 | Gene type: protein coding

About Hmgcr

Chromosome 13: 96,785,475-96,807,444 reverse strand.GRCm39:CM001006.3

This gene has 11 transcripts (splice variants), 206 orthologues and is associated with 3 phenotypes. Broad expression in CNS E18 (RPKM 39.9), CNS E11.5 (RPKM 3.5) and 25 other tissues.

Summary

Enables hydroxymethylglutaryl-CoA reductase (NADPH) activity. Involved in negative regulation of amyloid-beta clearance; negative regulation of protein catabolic process; and negative regulation of protein secretion. Acts upstream of or within Cholesterol biosynthetic process; negative regulation of MAP kinase activity; and visual learning. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane and peroxisomal membrane. Is expressed in several structures, including autopod; branchial arch; central nervous system; forelimb bud; and ganglia. Human ortholog(s) of this gene implicated in several diseases, including asthma; coronary artery disease (multiple); dementia; diabetes mellitus (multiple); and neurodegenerative disease (multiple). Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). [provided by Alliance of Genome Resources, Apr 2022]

Hmgcr Products(3)

mRNA Protein Name
NM_001360166.1 NP_001347095.1 3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform 2
NM_001360165.1 NP_001347094.1 3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform 1
NM_008255.2 NP_032281.2 3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform 1

Hmgcr Protein Structure

2A060605

2A060605: TIGR00920 (0 - 886)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 887 a.a.
Protein Preferred Names Protein Names

3-hydroxy-3-methylglutaryl-coenzyme A reductase

3-hydroxy-3-methylglutaryl-CoA reductase

HMG-CoA reductase

Related Agents

Approval
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17504 Rosuvastatin Calcium 99.77% Yes
HY-119695A Simvastatin acid ammonium Inhibitor 99.70% Unkown
HY-17504B Rosuvastatin Sodium 99.85% Yes
HY-115292 Simvastatin hydroxy acid sodium Inhibitor ≥99.0% Unkown
HY-119695 Simvastatin acid Inhibitor / Unkown
HY-119695B Simvastatin acid calcium hydrate Inhibitor / Unkown
Pre-clinical Phase
Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15483 DY131 99.72% Unkown
HY-107855 DL-Mevalonolactone ≥98.0% Unkown
HY-N0686 Pseudoprotodioscin Inhibitor 98.76% Unkown
HY-106281 Bemfivastatin Inhibitor 99.48% Unkown
HY-17504R Rosuvastatin Calcium (Standard) 99.94% Unkown
HY-114316 HMG499 Inhibitor 96.78% Unkown
HY-101873S Atorvastatin lactone-d5 Inhibitor / Unkown
HY-116241 L-157012 Inhibitor / Unkown
HY-119695AS1 Simvastatin acid-d9 ammonium Inhibitor / Unkown
HY-147195 QH536 Inhibitor / Unkown
HY-N11637 Ganoderenic acid K Inhibitor / Unkown
HY-RS06238 HMGCR Human Pre-designed siRNA Set A / Unkown
HY-RS06239 Hmgcr Mouse Pre-designed siRNA Set A / Unkown
HY-RS06240 Hmgcr Rat Pre-designed siRNA Set A / Unkown
HY-17504BS2 Rosuvastatin-13C,d3 sodium / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hmgcr NCBI NCBI:3156