2. Gene
  3. Htr4 - 5 hydroxytryptamine (serotonin) receptor 4 Gene

Htr4 - 5 hydroxytryptamine (serotonin) receptor 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as 5-HT4; 5HTR4; 5-HT-4; 5-HT

Gene ID: 15562 | Gene type: protein coding

About Htr4

Chromosome 18: 62,457,275-62,629,648 forward strand.GRCm39:CM001011.3

This gene has 4 transcripts (splice variants), 201 orthologues, 32 paralogues and is associated with 11 phenotypes. Biased expression in bladder adult (RPKM 1.5), colon adult (RPKM 1.5) and 6 other tissues.

Summary

Predicted to enable G protein-coupled serotonin receptor activity; neurotransmitter receptor activity; and serotonin binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway; chemical synaptic transmission; and gamma-aminobutyric acid signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasm and membrane. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in several structures, including brain; gallbladder; genitourinary system; gut; and spinal cord. Used to study anorexia nervosa. Orthologous to human HTR4 (5-hydroxytryptamine receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Htr4 Products(10)

mRNA Protein Name
NM_001364959.1 NP_001351888.1 5-hydroxytryptamine receptor 4 isoform 5
NM_001364956.1 NP_001351885.1 5-hydroxytryptamine receptor 4 isoform 2
NM_001364957.1 NP_001351886.1 5-hydroxytryptamine receptor 4 isoform 3
NM_001364958.1 NP_001351887.1 5-hydroxytryptamine receptor 4 isoform 4
NM_008313.4 NP_032339.2 5-hydroxytryptamine receptor 4 isoform 1
NM_001364956.1 NP_001351885.1 5-hydroxytryptamine receptor 4 isoform 2
NM_001364957.1 NP_001351886.1 5-hydroxytryptamine receptor 4 isoform 3
NM_001364958.1 NP_001351887.1 5-hydroxytryptamine receptor 4 isoform 4
NM_001364959.1 NP_001351888.1 5-hydroxytryptamine receptor 4 isoform 5
NM_008313.4 NP_032339.2 5-hydroxytryptamine receptor 4 isoform 1

Htr4 Protein Structure

7tmA_5-HT4

7tmA_5-HT4: cd15056 (19 - 322)

7tmA_5-HT4

7tmA_5-HT4: cd15056 (20 - 46)

7tmA_5-HT4

7tmA_5-HT4: cd15056 (54 - 80)

7tmA_5-HT4

7tmA_5-HT4: cd15056 (92 - 122)

7tmA_5-HT4

7tmA_5-HT4: cd15056 (135 - 158)

7tmA_5-HT4

7tmA_5-HT4: cd15056 (188 - 217)

7tmA_5-HT4

7tmA_5-HT4: cd15056 (251 - 281)

7tmA_5-HT4

7tmA_5-HT4: cd15056 (290 - 315)

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  • 388 a.a.
Protein Preferred Names Protein Names

5-hydroxytryptamine receptor 4

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14153A Tegaserod maleate 99.93% Unkown
HY-14153 Tegaserod 99.89% Unkown
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06474 HTR4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06475 Htr4 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06476 Htr4 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-14153S Tegaserod-d11 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Htr4 NCBI NCBI:3360