Htr4 - 5 hydroxytryptamine (serotonin) receptor 4 Gene

Mus musculus

Also known as 5-HT4; 5HTR4; 5-HT-4; 5-HT

Gene ID: 15562 | Gene type: protein coding

About Htr4

Chromosome 18: 62,457,275-62,629,648 forward strand.GRCm39:CM001011.3

This gene has 4 transcripts (splice variants), 201 orthologues, 32 paralogues and is associated with 11 phenotypes. Biased expression in bladder adult (RPKM 1.5), colon adult (RPKM 1.5) and 6 other tissues.

Summary

Predicted to enable G protein-coupled serotonin receptor activity; neurotransmitter receptor activity; and serotonin binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway; chemical synaptic transmission; and gamma-aminobutyric acid signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasm and membrane. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in several structures, including brain; gallbladder; genitourinary system; gut; and spinal cord. Used to study anorexia nervosa. Orthologous to human HTR4 (5-hydroxytryptamine receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Htr4 Products(10)

mRNA	Protein	Name
NM_001364959.1	NP_001351888.1	5-hydroxytryptamine receptor 4 isoform 5
NM_001364956.1	NP_001351885.1	5-hydroxytryptamine receptor 4 isoform 2
NM_001364957.1	NP_001351886.1	5-hydroxytryptamine receptor 4 isoform 3
NM_001364958.1	NP_001351887.1	5-hydroxytryptamine receptor 4 isoform 4
NM_008313.4	NP_032339.2	5-hydroxytryptamine receptor 4 isoform 1
NM_001364956.1	NP_001351885.1	5-hydroxytryptamine receptor 4 isoform 2
NM_001364957.1	NP_001351886.1	5-hydroxytryptamine receptor 4 isoform 3
NM_001364958.1	NP_001351887.1	5-hydroxytryptamine receptor 4 isoform 4
NM_001364959.1	NP_001351888.1	5-hydroxytryptamine receptor 4 isoform 5
NM_008313.4	NP_032339.2	5-hydroxytryptamine receptor 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled serotonin receptor activity	IDA IDA: Inferred from direct assay	33299969	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19661922	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	33299969	MGI
involved in maintenance of gastrointestinal epithelium	IDA IDA: Inferred from direct assay	33299969	MGI
involved in mucus secretion	IDA IDA: Inferred from direct assay	33299969	MGI
involved in regulation of postsynapse assembly	EXP EXP: Inferred from Experiment	32060357	MGI
involved in regulation of postsynapse assembly	IDA IDA: Inferred from direct assay	32060357	MGI
involved in regulation of postsynapse assembly	IMP IMP: Inferred from mutant phenotype	32060357	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	32060357	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	29706583	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	32060357	MGI
is active in plasma membrane	IDA IDA: Inferred from direct assay	33299969	MGI
is active in postsynapse	IDA IDA: Inferred from direct assay	29706583	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Htr4 Protein Structure

7tmA_5-HT4

0
100
200
300
388 a.a.

Protein Preferred Names

Protein Names

5-hydroxytryptamine receptor 4

Htr4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Htr4	P97288	SRC	Homo sapiens	P12931	Anti Tag CoIP	19661922
Cross	Htr4	P97288	SRC	Homo sapiens	P12931	Pull Down	19661922
Cross	Htr4	P97288	GRK5	Homo sapiens	P34947	Anti Tag CoIP	19661922
Cross	Htr4	P97288	GRK5	Homo sapiens	P34947	Competition Binding	19661922
Cross	Htr4	P97288	GRK5	Homo sapiens	P34947	Pull Down	19661922

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14153A	Tegaserod maleate		99.90%	Unkown
HY-14153	Tegaserod		99.89%	Unkown

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06474	HTR4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06475	Htr4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06476	Htr4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-14153S	Tegaserod-d11		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Htr4	NCBI	NCBI:3360

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