2. Gene
  3. Ide - insulin degrading enzyme Gene

Ide - insulin degrading enzyme Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as 1300012G03Rik; 4833415K22Rik

Gene ID: 15925 | Gene type: protein coding

About Ide

Summary

Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and peptide binding activity. Involved in Insulin catabolic process. Acts upstream of or within amyloid-beta clearance and response to oxidative stress. Located in extracellular exosome. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to human IDE (Insulin degrading Enzyme). [provided by Alliance of Genome Resources, Apr 2022]

Ide Products(1)

mRNA Protein Name
NM_031156.4 NP_112419.4 insulin-degrading enzyme
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables endopeptidase activity IDA
IDA: Inferred from direct assay
27703010 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within amyloid-beta clearance IDA
IDA: Inferred from direct assay
26637123 MGI
involved in amyloid-beta clearance IMP
IMP: Inferred from mutant phenotype
20876579 MGI
involved in insulin catabolic process IDA
IDA: Inferred from direct assay
27703010 MGI
involved in insulin catabolic process IMP
IMP: Inferred from mutant phenotype
24847884 MGI
involved in insulin receptor recycling IDA
IDA: Inferred from direct assay
27703010 MGI
involved in protein catabolic process IMP
IMP: Inferred from mutant phenotype
20876579 MGI
acts upstream of or within response to oxidative stress IDA
IDA: Inferred from direct assay
26637123 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in endosome lumen IDA
IDA: Inferred from direct assay
27703010 MGI
located in extracellular exosome IMP
IMP: Inferred from mutant phenotype
20876579 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

insulin-degrading enzyme

insulin protease

insulinase

insulysin

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-101569 Darovasertib Inhibitor 99.42% Phase 2
Pre-clinical Phase
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100533 IDE1 98.51% Unkown
HY-N7135 Tropolone Inhibitor 99.93% Unkown
HY-100534 IDE 2 Agonist 99.00% Unkown
HY-117878 ML345 Inhibitor 98.30% Unkown
HY-110197 6bK TFA 99.35% Unkown
HY-W157689 IDE-IN-2 Inhibitor 98.04% Unkown
HY-114611 BDM44768 / Unkown
HY-12655 IDE-IN-1 Inhibitor / Unkown
HY-143401 Hit 1 Activator / Unkown
HY-RS06526 IDE Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W616806 Sodium 6-oxo-3,6-dihydropurin-7-ide / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ide NCBI NCBI:3416
Canis familiaris Ide NCBI NCBI:477768
Macaca fascicularis Ide NCBI NCBI:102128252
Susscrofa domestica Ide NCBI
Rattus norvegicus Ide NCBI NCBI:25700
Macaca mulatta Ide NCBI NCBI:698640