Ide - insulin degrading enzyme Gene

Rattus norvegicus

Also known as INSDEGM

Gene ID: 25700 | Gene type: protein coding

About Ide

Summary

Enables several functions, including ATP binding activity; ATP hydrolysis activity; and peptide binding activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; amyloid-beta metabolic process; and negative regulation of proteolysis. Located in several cellular components, including cell surface; extracellular space; and peroxisomal matrix. Part of cytosolic Proteasome complex. Used to study Alzheimer's disease and type 2 diabetes mellitus. Biomarker of Alzheimer's disease and non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IDE (Insulin degrading Enzyme). [provided by Alliance of Genome Resources, Apr 2022]

Ide Products(1)

mRNA	Protein	Name
NM_013159.2	NP_037291.1	insulin-degrading enzyme

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IMP IMP: Inferred from mutant phenotype	15749695	RGD
enables ATP binding	IPI IPI: Inferred from physical interaction	17259336	RGD
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	17259336	RGD
enables amyloid-beta binding	IPI IPI: Inferred from physical interaction	18411275	RGD
enables beta-endorphin binding	IMP IMP: Inferred from mutant phenotype	15749695	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	15494400	RGD
enables insulin binding	IMP IMP: Inferred from mutant phenotype	15749695	RGD
enables metalloendopeptidase activity	IDA IDA: Inferred from direct assay	15494400	RGD
enables metalloendopeptidase activity	IMP IMP: Inferred from mutant phenotype	15749695	RGD
enables peptide hormone binding	IPI IPI: Inferred from physical interaction	15494400	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	9000694	RGD
enables zinc ion binding	IMP IMP: Inferred from mutant phenotype	15749695	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in amyloid-beta clearance	IGI IGI: Inferred from genetic interaction	19406747	RGD
involved in amyloid-beta clearance	IMP IMP: Inferred from mutant phenotype	10684867	RGD
involved in amyloid-beta clearance by cellular catabolic process	IMP IMP: Inferred from mutant phenotype	18941241	RGD
involved in amyloid-beta metabolic process	IMP IMP: Inferred from mutant phenotype	15749695	RGD
involved in hormone catabolic process	IDA IDA: Inferred from direct assay	15494400	RGD
involved in negative regulation of proteolysis	IDA IDA: Inferred from direct assay	9000694	RGD
involved in protein catabolic process	IDA IDA: Inferred from direct assay	11235899	RGD
involved in proteolysis involved in protein catabolic process	IMP IMP: Inferred from mutant phenotype	15749695	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	10684867	RGD
part of cytosolic proteasome complex	IDA IDA: Inferred from direct assay	9000694	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	10684867	RGD
located in peroxisomal matrix	IDA IDA: Inferred from direct assay	11235899	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

insulin-degrading enzyme

insulin protease	insulinase
insulysin

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-101569	Darovasertib	Inhibitor	99.42%	Phase 2

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100533	IDE1		98.51%	Unkown
HY-N7135	Tropolone	Inhibitor	99.93%	Unkown
HY-100534	IDE 2	Agonist	99.00%	Unkown
HY-117878	ML345	Inhibitor	98.30%	Unkown
HY-110197	6bK TFA		99.35%	Unkown
HY-W157689	IDE-IN-2	Inhibitor	98.04%	Unkown
HY-114611	BDM44768		/	Unkown
HY-12655	IDE-IN-1	Inhibitor	/	Unkown
HY-143401	Hit 1	Activator	/	Unkown
HY-RS06526	IDE Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W616806	Sodium 6-oxo-3,6-dihydropurin-7-ide		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ide	NCBI	NCBI:3416
Canis familiaris	Ide	NCBI	NCBI:477768
Macaca fascicularis	Ide	NCBI	NCBI:102128252
Mus musculus	Ide	NCBI	NCBI:15925
Susscrofa domestica	Ide	NCBI
Macaca mulatta	Ide	NCBI	NCBI:698640

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