IDE - insulin degrading enzyme Gene

Homo sapiens

Also known as INSULYSIN

Gene ID: 3416 | Gene type: protein coding

About IDE

Cytogenetic location: 10q23.33 Genomic coordinates (GRCh38): 10:92,451,684-92,574,093 (from NCBI)

This gene has 38 transcripts (splice variants), 225 orthologues and 6 paralogues. Ubiquitous expression in skin (RPKM 17.4), testis (RPKM 9.9) and 25 other tissues.

Summary

This gene encodes a zinc metallopeptidase that degrades intracellular Insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse Peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this Enzyme for Insulin results in insulin-mediated inhibition of the degradation of other Peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]

IDE Products(8)

mRNA	Protein	Name
NM_001165946.2	NP_001159418.1	insulin-degrading enzyme isoform 2
NM_001322793.2	NP_001309722.1	insulin-degrading enzyme isoform 3
NM_001322794.2	NP_001309723.1	insulin-degrading enzyme isoform 4
NM_001322795.2	NP_001309724.1	insulin-degrading enzyme isoform 5
NM_001322796.1	NP_001309725.1	insulin-degrading enzyme isoform 5
NM_001322797.2	NP_001309726.1	insulin-degrading enzyme isoform 6
NM_001410974.1	NP_001397903.1	insulin-degrading enzyme isoform 7
NM_004969.4	NP_004960.2	insulin-degrading enzyme isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	17613531	GOA
enables endopeptidase activity	IDA IDA: Inferred from direct assay	20364150	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	17051221	GOA
enables insulin binding	IDA IDA: Inferred from direct assay	17051221	GOA
enables insulin binding	IPI IPI: Inferred from physical interaction	20082125	GOA
enables metalloendopeptidase activity	IDA IDA: Inferred from direct assay	17051221	GOA
enables peptide binding	IPI IPI: Inferred from physical interaction	20082125	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17051221	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	17613531	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	17613531	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in amyloid-beta clearance	IMP IMP: Inferred from mutant phenotype	10684867	GOA
involved in amyloid-beta clearance by cellular catabolic process	IMP IMP: Inferred from mutant phenotype	23525105	GOA
involved in amyloid-beta metabolic process	IDA IDA: Inferred from direct assay	9830016	GOA
involved in antigen processing and presentation of endogenous peptide antigen via MHC class I	IMP IMP: Inferred from mutant phenotype	20364150	GOA
involved in bradykinin catabolic process	IDA IDA: Inferred from direct assay	17613531	GOA
involved in hormone catabolic process	IDA IDA: Inferred from direct assay	19321446	GOA
involved in insulin catabolic process	IDA IDA: Inferred from direct assay	9231799	GOA
involved in insulin metabolic process	IDA IDA: Inferred from direct assay	18448515	GOA
involved in peptide catabolic process	IDA IDA: Inferred from direct assay	20364150	GOA
involved in positive regulation of protein binding	IDA IDA: Inferred from direct assay	9830016	GOA
involved in protein catabolic process	IMP IMP: Inferred from mutant phenotype	20364150	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	18602473	GOA
involved in proteolysis involved in protein catabolic process	IDA IDA: Inferred from direct assay	9830016	GOA
involved in regulation of aerobic respiration	IGI IGI: Inferred from genetic interaction	23525105	GOA
involved in ubiquitin recycling	IDA IDA: Inferred from direct assay	21185309	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in basolateral plasma membrane	IMP IMP: Inferred from mutant phenotype	16511862	GOA
located in cell surface	IDA IDA: Inferred from direct assay	16511862	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	9231799	GOA
located in cytosol	IDA IDA: Inferred from direct assay	9830016	GOA
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	16511862	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	9830016	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	15285718	GOA
NOT located in nucleus	IDA IDA: Inferred from direct assay	18226493	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9231799	GOA
located in peroxisome	IDA IDA: Inferred from direct assay	9231799	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IDE Protein Structure

Peptidase_M16

Peptidase_M16_C

0
200
400
600
800
1019 a.a.

Protein Preferred Names

Protein Names

insulin-degrading enzyme

Abeta-degrading protease

Recombinant IDE Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70291	Insulysin/IDE Protein, Human (HEK293, His)	P14735-1 (M42-L1019)	≥95%

Related Diseases

Diseases

Alias

Glucose Intolerance

Glucose: Intolerance	Glucose: Malabsorption
Malabsorption Of Glucose	Impaired Glucose Tolerance

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Alzheimer Disease 6

Ad6	Alzheimer Disease 6, Late-Onset
Alzheimer'S Disease 6	Alzheimer Disease 6, Late Onset

Diabetes Mellitus

Diabetes

Amyloidosis

Amyloid Disease	Amyloid
Amyloid Degeneration	Amyloidosis Nos
Amyloid Deposition	Amyloid Infiltration
Idiopathic Amyloidosis	Hyaloid Degeneration
Lardaceous Degeneration

Cerebral Amyloid Angiopathy, Cst3-Related

Cerebral Amyloid Angiopathy	Hereditary Cerebral Hemorrhage With Amyloidosis
Hchwa	Hereditary Cystatin C Amyloid Angiopathy
Cerebral Amyloid Angiopathy, Familial	Amyloidosis, Cerebroarterial, Icelandic Type
Amyloidosis Vi	Cerebral Hemorrhage, Hereditary, With Amyloidosis
Cst3-Related Cerebral Amyloid Angiopathy	Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant
Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant	Caa, Familial
Cerebral Amyloid Angiopathy, Genetic	Acys Amyloidosis
Cst3-Related Amyloidosis	Cystatin Amyloidosis
Hchwa, Icelandic Type	Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type
Amyloidosis 6	AMYL6
Acys	Caa
Cerebral Amyloid Angiopathy Cst3-Related	Cerebroarterial Amyloidosis Icelandic Type
Cystatin C Amyloidosis	Hccaa
Hchwai	Hchwa-I
Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type	Cerebral Amyloid Angiopathy Familial
Angiopathy, Amyloid, Cerebral, Cst3-Related	Hereditary Cerebral Amyloid Angiopathy, Icelandic Type
Familial Cerebral Amyloid Angiopathy	Cerebral Amyloid Angiopathy, Hereditary

Dementia

Dementias	Presenile Dementia
Alzheimer Type Dementia	Alzheimer Sclerosis
Alzheimer Disease Dementia	Alzheimer Dementia
Primary Degenerative Alzheimer Type Dementia	End Stage Alzheimer'S Dementia
Alzheimer'S Type Atypical Dementia	Alzheimer Type Presenile Dementia
Early Onset Alzheimer Dementia	Dementia In Alzheimer Disease Type 2
Dementia In Alzheimer Disease With Early Onset	Early Onset Alzheimer Type Dementia, Uncomplicated
Primary Degenerative Alzheimer Type Dementia, Early Onset	Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated
Alzheimer Disease Dementia With Early Onset	Presenile Sclerosis
Presenile Brain Sclerosis	Presenile Alzheimer Brain Sclerosis
Late Onset Alzheimer Dementia	Dementia In Alzheimer Disease Type 1
Dementia In Alzheimer Disease With Late Onset	Primary Degenerative Alzheimer Type Dementia, Late Onset
Sdat - [Senile Dementia, Alzheimer Type]	Alzheimer Disease Dementia With Late Onset
Late Onset Alzheimer Brain Sclerosis	Senile Alzheimer Brain Disease
Senile Alzheimer Brain Sclerosis	Senile Primary Degenerative Alzheimer Type Dementia
Senile Dementia Of The Alzheimer Type	Arteriosclerotic Dementia
Strategic-Infarct Dementia	Post Stroke Dementia
Vascular Cognitive Impairment	Vascular Dementia
Dementia Of The Lewy Body Type	Dementia With Lewy Bodies
Sdlt - [Senile Dementia Of The Lewy Body Type]	Senile Dementia Of The Lewy Body Type
Alcohol-Related Dementia	Alcoholic Dementia Nos
Alcohol-Induced Dementia	Alcoholic Brain Syndrome
Chronic Alcoholic Brain Syndrome	Alcohol Dementia
Late Onset Alcoholic Psychosis	Residual And Late-Onset Alcohol-Induced Psychotic Disorder
Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder	Late-Onset Psychoactive Substance-Induced Psychotic Disorder
Inhalant Dementia	Volatile Solvents Dementia
Dementia In Paralysis Agitans	Pdd - [Parkinson Disease Dementia]
Dementia Syndrome Of Parkinson Disease	Dementia In Parkinson Disease
Parkinson Related Dementia	Dementia In Huntington Chorea
Hiv - [Human Immunodeficiency Virus] Dementia	Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex
Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex	Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex
Aids Related Dementia	Dementia Due To Niacin Deficiency

Familial Atrial Fibrillation

Atrial Fibrillation, Familial	Atfb
Atrial Fibrillation Autosomal Dominant	Autosomal Dominant Atrial Fibrillation
Auricular Fibrillation	Atrial Fibrillation
Atrial Fibrillation, Familial, 1

Hyperinsulinism

Hyperinsulinemia

Cerebral Amyloid Angiopathy, App-Related

Hchwad	Amyloidosis, Cerebroarterial, App-Related
Amyloidosis, Hereditary, With Cerebral Hemorrhage, Dutch Variant	Cerebral Amyloid Angiopathy, App-Related, Dutch Variant
Cerebral Amyloid Angiopathy, App-Related, Iowa Variant	Cerebral Amyloid Angiopathy, App-Related, Italian Variant
Cerebral Amyloid Angiopathy, App-Related, Flemish Variant	Cerebral Amyloid Angiopathy, App-Related, Arctic Variant
Cerebral Amyloid Angiopathy, Dutch, Italian, Iowa, Flemish, Arctic Variants	App-Related Cerebral Amyloid Angiopathy
Abetaa21g Amyloidosis	Abeta Amyloidosis, Italian Type
Abeta Amyloidosis, Arctic Type	Abeta Amyloidosis, Iowa Type
Abeta Amyloidosis, Dutch Type	Hchwa-D
Abeta Amyloidosis, Flemish Type	Abetaa21g-Related Amyloidosis
Hchwa, Flemish Type	Hereditary Cerebral Hemorrhage With Amyloidosis, Flemish Type
Abetae22k Amyloidosis	Hchwa, Italian Type
Hereditary Cerebral Hemorrhage With Amyloidosis, Italian Type	Abetae22g Amyloidosis
Hchwa, Arctic Type	Hereditary Cerebral Hemorrhage With Amyloidosis, Arctic Type
Abetad23n Amyloidosis	Hchwa, Iowa Type
Hereditary Cerebral Hemorrhage With Amyloidosis, Iowa Type	Abetal34v Amyloidosis
Abeta Amyloidosis, Piedmont Type	Abetal34v-Related Amyloidosis
Hchwa, Piedmont Type	Hereditary Cerebral Hemorrhage With Amyloidosis, Piedmont Type
Abetae22q Amyloidosis	Hchwa, Dutch Type
Hereditary Cerebral Hemorrhage With Amyloidosis, Dutch Type	CAA-APP
Amyloidosis Cerebroarterial App-Related	Amyloidosis Hereditary With Cerebral Hemorrhage Dutch Variant
Cerebral Amyloid Angiopathy App-Related Arctic Variant	Cerebral Amyloid Angiopathy App-Related Dutch Variant
Cerebral Amyloid Angiopathy App-Related Flemish Variant	Cerebral Amyloid Angiopathy App-Related Iowa Variant
Cerebral Amyloid Angiopathy App-Related Italian Variant	Familial Occipital Calcifications With Hemorrhagic Strokes Leukoencephalopathy Arterial Dysplasia Dementia
Fochs-Ladd	Hereditary Cerebral Amyloid Angiopathy Dutch Type
Hereditary Cerebral Hemorrhage With Amyloidosis Dutch Type	Hereditary Cerebral Hemorrhage With Amyloidosis Italian Type
Cerebral Hemorrhage With Amyloidosis, Hereditary, Dutch Type

Mild Cognitive Impairment

Vascular Dementia

Dementia, Vascular	Multi Infarct Dementia
Multifocal Dementia	Dementia Vascular
Vascular Dementia, Susceptibility To	Dementia, Multi-Infarct
Multi-Infarct Dementia

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-101569	Darovasertib	Inhibitor	99.42%	Phase 2

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100533	IDE1		98.13%	Unkown
HY-N7135	Tropolone	Inhibitor	99.93%	Unkown
HY-117878	ML345	Inhibitor	98.30%	Unkown
HY-100534	IDE 2	Agonist	99.00%	Unkown
HY-110197	6bK TFA		99.35%	Unkown
HY-W157689	IDE-IN-2	Agonist	/	Unkown
HY-114611	BDM44768		/	Unkown
HY-12655	IDE-IN-1		/	Unkown
HY-143401	Hit 1		/	Unkown
HY-RS06526	IDE Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	IDE	NCBI	NCBI:477768
Macaca fascicularis	IDE	NCBI	NCBI:102128252
Mus musculus	IDE	NCBI	NCBI:15925
Susscrofa domestica	IDE	NCBI
Rattus norvegicus	IDE	NCBI	NCBI:25700
Macaca mulatta	IDE	NCBI	NCBI:698640

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