Il18 - interleukin 18 Gene

Mus musculus

Also known as Igif; Il-18

Gene ID: 16173 | Gene type: protein coding

About Il18

Summary

Enables cytokine activity. Involved in lipid homeostasis; positive regulation of cell differentiation; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including interleukin-18-mediated signaling pathway; positive regulation of NIK/NF-kappaB signaling; and positive regulation of interferon-gamma production. Located in extracellular space. Is expressed in several structures, including back skin; dorsal aorta; gut; lymphatic system; and reproductive system. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and hepatitis B. Orthologous to human IL18 (interleukin 18). [provided by Alliance of Genome Resources, Apr 2022]

Il18 Products(3)

mRNA	Protein	Name
NM_001357221.1	NP_001344150.1	interleukin-18 isoform a
NM_001357222.1	NP_001344151.1	interleukin-18 isoform b
NM_008360.2	NP_032386.1	interleukin-18 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytokine activity	IDA IDA: Inferred from direct assay	11894098	MGI
enables cytokine activity	IMP IMP: Inferred from mutant phenotype	12829194	MGI
enables receptor ligand activity	IDA IDA: Inferred from direct assay	10227969	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within T-helper 1 cell cytokine production	IDA IDA: Inferred from direct assay	15843532	MGI
acts upstream of or within T-helper 1 cell cytokine production	IGI IGI: Inferred from genetic interaction	15843532	MGI
acts upstream of or within cell population proliferation	IDA IDA: Inferred from direct assay	15843532	MGI
acts upstream of or within cell population proliferation	IGI IGI: Inferred from genetic interaction	15843532	MGI
involved in cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	12829194	MGI
involved in defense response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	30392956	MGI
involved in establishment of skin barrier	IMP IMP: Inferred from mutant phenotype	26638073	MGI
acts upstream of or within inflammatory response	IGI IGI: Inferred from genetic interaction	23132931	MGI
acts upstream of or within interleukin-18-mediated signaling pathway	IDA IDA: Inferred from direct assay	15843532	MGI
involved in interleukin-18-mediated signaling pathway	IDA IDA: Inferred from direct assay	30392956	MGI
acts upstream of or within interleukin-6 production	IDA IDA: Inferred from direct assay	15843532	MGI
acts upstream of or within natural killer cell activation	IDA IDA: Inferred from direct assay	10227969	MGI
acts upstream of or within natural killer cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	15843532	MGI
acts upstream of or within negative regulation of myoblast differentiation	IMP IMP: Inferred from mutant phenotype	23844157	MGI
acts upstream of or within neutrophil activation	IDA IDA: Inferred from direct assay	15843532	MGI
involved in positive regulation of T-helper 2 cell differentiation	IMP IMP: Inferred from mutant phenotype	12829194	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	26656097	MGI
acts upstream of or within positive regulation of gene expression	IDA IDA: Inferred from direct assay	19666510	MGI
involved in positive regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	26638073	MGI
involved in positive regulation of macrophage derived foam cell differentiation	IMP IMP: Inferred from mutant phenotype	12829194	MGI
involved in positive regulation of non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	10227969	MGI
acts upstream of or within positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	10227969	MGI
acts upstream of or within positive regulation of type II interferon production	IGI IGI: Inferred from genetic interaction	15843532	MGI
involved in positive regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	11907086	MGI
involved in triglyceride homeostasis	IMP IMP: Inferred from mutant phenotype	12829194	MGI
acts upstream of type II interferon production	IDA IDA: Inferred from direct assay	10227969	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in extracellular space	IDA IDA: Inferred from direct assay	30392956	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	15220916	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

interleukin-18

IFN-gamma-inducing factor	IL-1 gamma
interferon gamma-inducing factor	interleukin-1 gamma

Recombinant Il18 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70642	IL-18 Protein, Mouse (His)	P70380 (N36-S192)	≥95%
HY-P73181	IL-18 Protein, Mouse (solution)	P70380 (N36-S192)	≥95%
HY-P70642AF	Animal-Free IL-18 Protein, Mouse (His)	P70380 (N36-S192)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-101092	QS-21	Activator	99.67%	Phase 3
HY-13205	Belnacasan	Inhibitor	99.99%	Phase 2

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990591	GSK-1070806	Inhibitor	99.50%	Phase 2
HY-P99491	Camoteskimab	Inhibitor	98.41%	Phase 1

Pre-clinical Phase

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16990	Ac-YVAD-cmk	Inhibitor	98.94%	Unkown
HY-123879	BAA473		98.93%	Unkown
HY-156413	NLRP3 agonist 1	Agonist	99.01%	Unkown
HY-19676	Pralnacasan	Inhibitor	99.83%	Unkown
HY-150742	ODN 2336	Agonist	90.74%	Unkown
HY-W176629	Hydrocotarnine	Inhibitor	99.59%	Unkown
HY-147660	IMMH001	Agonist	98.10%	Unkown
HY-102019	NSC61610	Inhibitor	99.50%	Unkown
HY-149478	JT002	Inhibitor	99.49%	Unkown
HY-160793	NSC80734	Inhibitor	98.08%	Unkown
HY-164426	HEI3090	Activator	99.04%	Unkown
HY-150742A	ODN 2336 sodium		90.74%	Unkown
HY-158024A	(S)-NDT-19795	Inhibitor	/	Unkown
HY-111662	Fc 11a-2	Inhibitor	/	Unkown
HY-RS06708	IL18 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06709	IL18BP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06710	IL18R1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06711	IL18RAP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-119337	CE-2072	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Il18	NCBI	NCBI:3606
Canis lupus familiaris	Il18	NCBI

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