Klf4 - Kruppel-like factor 4 (gut) Gene

Mus musculus

Also known as EZF; Zie; Gklf

Gene ID: 16600 | Gene type: protein coding

About Klf4

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity; and beta-catenin binding activity. Involved in several processes, including canonical Wnt signaling pathway; positive regulation of core promoter binding activity; and transcription, DNA-templated. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; regulation of blastocyst development; and regulation of transcription, DNA-templated. Located in cytoplasm; euchromatin; and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; limb; and skin. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human KLF4 (Kruppel like factor 4). [provided by Alliance of Genome Resources, Apr 2022]

Klf4 Products(1)

mRNA	Protein	Name
NM_010637.3	NP_034767.2	Krueppel-like factor 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	22306741	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	22723415	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	17130451	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	28262547	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	22723415	MGI
enables RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity	IDA IDA: Inferred from direct assay	18396140	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	18396140	MGI
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	22723415	MGI
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	32467224	MGI
enables lncRNA binding	IDA IDA: Inferred from direct assay	36662856	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19816951	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8940147	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	16954384	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	23372771	MGI
involved in canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	22723415	MGI
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: Inferred from expression pattern	20439489	MGI
acts upstream of or within epidermal cell differentiation	IMP IMP: Inferred from mutant phenotype	10431239	MGI
involved in epidermis development	IMP IMP: Inferred from mutant phenotype	32467224	MGI
acts upstream of or within epidermis morphogenesis	IMP IMP: Inferred from mutant phenotype	10431239	MGI
involved in establishment of skin barrier	IMP IMP: Inferred from mutant phenotype	32467224	MGI
acts upstream of or within fat cell differentiation	IMP IMP: Inferred from mutant phenotype	22306741	MGI
involved in fat cell differentiation	IMP IMP: Inferred from mutant phenotype	18396140	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	27208706	MGI
acts upstream of or within glandular epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	17060454	MGI
acts upstream of or within negative regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	24129709	MGI
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	22491752	MGI
acts upstream of or within negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	8702718	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16954384	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17060454	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	26691508	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22306741	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18396140	MGI
acts upstream of or within post-embryonic camera-type eye development	IMP IMP: Inferred from mutant phenotype	17060454	MGI
acts upstream of or within regulation of axon regeneration	IGI IGI: Inferred from genetic interaction	24129709	MGI
acts upstream of or within regulation of axon regeneration	IMP IMP: Inferred from mutant phenotype	24129709	MGI
acts upstream of or within regulation of blastocyst development	IMP IMP: Inferred from mutant phenotype	29593216	MGI
involved in regulation of cell differentiation	IDA IDA: Inferred from direct assay	19816951	MGI
acts upstream of or within regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	17671182	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19796622	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	36662856	MGI
acts upstream of or within response to retinoic acid	IDA IDA: Inferred from direct assay	18400104	MGI
acts upstream of or within somatic stem cell population maintenance	IDA IDA: Inferred from direct assay	15358627	MGI
involved in stem cell population maintenance	IDA IDA: Inferred from direct assay	19816951	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22306741	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	24129709	MGI
located in euchromatin	IDA IDA: Inferred from direct assay	22723415	MGI
located in nucleus	IDA IDA: Inferred from direct assay	19796622	MGI
is active in nucleus	IPI IPI: Inferred from physical interaction	32467224	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	22723415	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

Krueppel-like factor 4

Kruppel-like factor 4 (Gut enriched kruppel-like factor) (Epithelial zinc-finger protein EZF)	epithelial zinc finger protein EZF
gut-enriched krueppel-like factor

Klf4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Klf4	Q60793	BTRC	Homo sapiens	Q9Y297	Anti Tag CoIP	22307056
Cross	Klf4	Q60793	FBXW11	Homo sapiens	Q9UKB1	Anti Tag CoIP	22307056
Cross	Klf4	Q60793	STAU1	Homo sapiens	O95793	Anti Tag CoIP	29374155
Intra	Klf4	Q60793	Mapk3	Mus musculus	Q63844	Y2H	22307056
Intra	Klf4	Q60793	Mapk3	Mus musculus	Q63844	Anti Tag CoIP	22307056

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16291	APTO-253		98.86%	Phase 1

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12302	Kenpaullone	Inhibitor	98.20%	Unkown
HY-121917	Ro 31-7837		/	Unkown
HY-131923	DAPM	Inhibitor	/	Unkown
HY-16291A	APTO-253 hydrochloride	Inhibitor	/	Unkown
HY-RS07341	KLF4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Klf4	NCBI	NCBI:9314

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