1. Gene
  2. FBXW11 - F-box and WD repeat domain containing 11 Gene

FBXW11 - F-box and WD repeat domain containing 11 Gene

Homo sapiens

Also known as Hos; BTRC2; FBW1B; Fbw11; BTRCP2; FBXW1B; NEDJED

Gene ID: 23291 | Gene type: protein coding

About FBXW11

Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:171,861,549-172,006,638 (from NCBI)

This gene has 12 transcripts (splice variants), 238 orthologues, 14 paralogues and is associated with 3 phenotypes. Ubiquitous expression in brain (RPKM 22.1), heart (RPKM 11.8) and 25 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008]

FBXW11 Products(10)

mRNA Protein Name
NM_001378974.1 NP_001365903.1 F-box/WD repeat-containing protein 11 isoform D
NM_001378975.1 NP_001365904.1 F-box/WD repeat-containing protein 11 isoform E
NM_001378976.1 NP_001365905.1 F-box/WD repeat-containing protein 11 isoform F
NM_001378977.1 NP_001365906.1 F-box/WD repeat-containing protein 11 isoform G
NM_001378978.1 NP_001365907.1 F-box/WD repeat-containing protein 11 isoform G
NM_001378979.1 NP_001365908.1 F-box/WD repeat-containing protein 11 isoform H
NM_001378980.1 NP_001365909.1 F-box/WD repeat-containing protein 11 isoform A
NM_012300.3 NP_036432.2 F-box/WD repeat-containing protein 11 isoform C
NM_033644.3 NP_387448.2 F-box/WD repeat-containing protein 11 isoform B
NM_033645.3 NP_387449.2 F-box/WD repeat-containing protein 11 isoform A
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12482991 GOA
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: Inferred from direct assay
10321728 GOA
Biological Process GO Annotation Evidence Reference Source
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
20347421 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
19966869 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
10644755 GOA
involved in positive regulation of proteolysis IMP
IMP: Inferred from mutant phenotype
16885022 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
10644755 GOA
involved in protein destabilization IMP
IMP: Inferred from mutant phenotype
16885022 GOA
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
20347421 GOA
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
16885022 GOA
Cellular Component GO Annotation Evidence Reference Source
part of SCF ubiquitin ligase complex IDA
IDA: Inferred from direct assay
16880511 GOA
located in centrosome IDA
IDA: Inferred from direct assay
21399614 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXW11 Protein Structure

Beta-TrCP_D

Beta-TrCP_D: D domain of beta-TrCP (77 - 116)

F-box-like

F-box-like: F-box-like (130 - 167)

WD40

WD40: WD domain, G-beta repeat (239 - 266)

WD40

WD40: WD domain, G-beta repeat (271 - 306)

WD40

WD40: WD domain, G-beta repeat (310 - 346)

WD40

WD40: WD domain, G-beta repeat (357 - 389)

WD40

WD40: WD domain, G-beta repeat (394 - 429)

WD40

WD40: WD domain, G-beta repeat (434 - 469)

WD40

WD40: WD domain, G-beta repeat (484 - 518)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 542 a.a.
Protein Preferred Names Protein Names

F-box/WD repeat-containing protein 11

F-box and WD repeats protein beta-TrCP2

FBXW11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
FBXW11 Q9UKB1 FOXN2 Homo sapiens P32314
TAP
25609649
Intra
FBXW11 Q9UKB1 FOXN2 Homo sapiens P32314
Pull Down
25609649
Intra
FBXW11 Q9UKB1 IFNAR1 Homo sapiens P17181
Anti Tag CoIP
14532120
Intra
FBXW11 Q9UKB1 IFNAR1 Homo sapiens P17181
Pull Down
14532120
Intra
FBXW11 Q9UKB1 IFNAR1 Homo sapiens P17181
Anti Bait CoIP
14532120
Intra
FBXW11 Q9UKB1 NFKBIA Homo sapiens P25963
TAP
14743216
Intra
FBXW11 Q9UKB1 SKP1 Homo sapiens P63208
Anti Tag CoIP
19159283
Intra
FBXW11 Q9UKB1 SKP1 Homo sapiens P63208
TAP
17510365
Intra
FBXW11 Q9UKB1 SKP1 Homo sapiens P63208
Anti Tag CoIP
15070733
Intra
FBXW11 Q9UKB1 SKP1 Homo sapiens P63208
Anti Tag CoIP
19615732
Intra
FBXW11 Q9UKB1 SKP1 Homo sapiens P63208
TAP
25609649
Intra
FBXW11 Q9UKB1 SKP1 Homo sapiens P63208
TAP
21145461
Intra
FBXW11 Q9UKB1 CUL1 Homo sapiens Q13616
Anti Tag CoIP
19615732
Intra
FBXW11 Q9UKB1 CUL1 Homo sapiens Q13616
Anti Tag CoIP
18354482
Intra
FBXW11 Q9UKB1 CUL1 Homo sapiens Q13616
Anti Tag CoIP
21145461
Intra
FBXW11 Q9UKB1 CUL1 Homo sapiens Q13616
TAP
21145461
Intra
FBXW11 Q9UKB1 CUL1 Homo sapiens Q13616
TAP
25609649
Intra
FBXW11 Q9UKB1 MDM2 Homo sapiens Q00987
Anti Tag CoIP
20708156
Intra
FBXW11 Q9UKB1 MDM2 Homo sapiens Q00987
Pull Down
20708156
Intra
FBXW11 Q9UKB1 CTNNB1 Homo sapiens P35222
TAP
25609649
Intra
FBXW11 Q9UKB1 CTNNB1 Homo sapiens P35222
TAP
17510365
Intra
FBXW11 Q9UKB1 AMER1 Homo sapiens Q5JTC6
Anti Tag CoIP
33961781
Intra
FBXW11 Q9UKB1 AMER1 Homo sapiens Q5JTC6
TAP
17510365
Intra
FBXW11 Q9UKB1 AXIN1 Homo sapiens O15169
Anti Bait CoIP
22682247
Intra
FBXW11 Q9UKB1 INAVA Homo sapiens Q3KP66
Anti Tag CoIP
29420262
Intra
FBXW11 Q9UKB1 WEE1 Homo sapiens P30291
PLA
25241761
Intra
FBXW11 Q9UKB1 WEE1 Homo sapiens P30291
Anti Tag CoIP
15070733
Intra
FBXW11 Q9UKB1 REST Homo sapiens Q13127
Anti Tag CoIP
18354482
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Neurodevelopmental, Jaw, Eye, And Digital Syndrome

NEDJED

Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder

Rift Valley Fever

Rfv - [Rift Valley Fever]

Human Immunodeficiency Virus Type 1

Aids

Hiv/Aids

Aids, Delayed/Rapid Progression To

Hiv-1, Susceptibility To

Hiv-1 Viremia, Susceptibility To

Human Immunodeficiency Virus Type 1, Susceptibility To

Hiv-1

Aids, Slow Progression To

Rapid Progression To Aids From Hiv1 Infection

Hiv1 Infection, Resistance To

Hiv1 Infection

Hiv-1 Viremia

Aids, Resistance To

Aids, Rapid Progression To

Hiv/Aids, Susceptibility To

Hiv-1, Resistance To

Hiv1, Resistance To

Hiv1

Hiv-1 Disease, Delayed Progression Of

Hiv-1 Disease, Rapid Progression Of

Hiv Infection, Resistance To

Hiv Type 1, Susceptibility To

Hiv Type 1

Hiv-1 Infection

Human Immunodeficiency Virus I Infection

Acquired Immunodeficiency Syndrome

Hiv-Infection/Aids

Neuronopathy, Distal Hereditary Motor, Type Iid

HMN2D

Hmn Iid

Dhmn2d

Distal Hereditary Motor Neuronopathy Type 2d

Distal Hereditary Motor Neuropathy Type Iid

Neuronopathy, Distal Hereditary Motor, Type 2d

Neuropathy, Distal Hereditary Motor, Type Iid

Spinal Muscular Atrophy, Distal, Autosomal Dominant, Calf-Predominant

Distal Spinal Muscular Atrophy With Calf Predominance

Neuronopathy, Distal Hereditary Motor, 2d

Autosomal Dominant Spinal Muscular Atrophy Distal Calf-Predominant

Dhmn Iid

Neuropathy, Motor, Distal, Hereditary, Type 2d

Holoprosencephaly

Holoprosencephaly Sequence

Hpe

Hpe - [Holoprosencephaly]

Brachydactyly
Distal Hereditary Motor Neuronopathy Type 2

Distal Hereditary Motor Neuropathy, Type Ii

Distal Hereditary Motor Neuropathy Type 2

Distal Hereditary Motor Neuropathy Type Ii

Hmn Ii

Hmn2

Distal Hereditary Motor Neuronopathy, Type Ii

Distal Spinal Muscular Atrophy Type 2

Dhmn2

Dsma2

Neuropathy, Motor, Distal, Hereditary, Type Ii

Spinal Muscular Atrophy, Jerash Type

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus FBXW11 MGD MGI:2144023
Bos taurus FBXW11 VGNC VGNC:28922
Felis catus FBXW11 VGNC VGNC:62200
Canis familiaris FBXW11 VGNC VGNC:40792
Rattus norvegicus FBXW11 RGD RGD:1309121
Macaca mulatta FBXW11 VGNC VGNC:72500