FBXW11 - F-box and WD repeat domain containing 11 Gene

Homo sapiens

Also known as Hos; BTRC2; FBW1B; Fbw11; BTRCP2; FBXW1B; NEDJED

Gene ID: 23291 | Gene type: protein coding

About FBXW11

Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:171,861,549-172,006,638 (from NCBI)

This gene has 12 transcripts (splice variants), 238 orthologues, 14 paralogues and is associated with 3 phenotypes. Ubiquitous expression in brain (RPKM 22.1), heart (RPKM 11.8) and 25 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008]

FBXW11 Products(10)

mRNA	Protein	Name
NM_001378974.1	NP_001365903.1	F-box/WD repeat-containing protein 11 isoform D
NM_001378975.1	NP_001365904.1	F-box/WD repeat-containing protein 11 isoform E
NM_001378976.1	NP_001365905.1	F-box/WD repeat-containing protein 11 isoform F
NM_001378977.1	NP_001365906.1	F-box/WD repeat-containing protein 11 isoform G
NM_001378978.1	NP_001365907.1	F-box/WD repeat-containing protein 11 isoform G
NM_001378979.1	NP_001365908.1	F-box/WD repeat-containing protein 11 isoform H
NM_001378980.1	NP_001365909.1	F-box/WD repeat-containing protein 11 isoform A
NM_012300.3	NP_036432.2	F-box/WD repeat-containing protein 11 isoform C
NM_033644.3	NP_387448.2	F-box/WD repeat-containing protein 11 isoform B
NM_033645.3	NP_387449.2	F-box/WD repeat-containing protein 11 isoform A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12482991	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	10321728	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	20347421	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19966869	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	10644755	GOA
involved in positive regulation of proteolysis	IMP IMP: Inferred from mutant phenotype	16885022	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	10644755	GOA
involved in protein destabilization	IMP IMP: Inferred from mutant phenotype	16885022	GOA
involved in protein polyubiquitination	IDA IDA: Inferred from direct assay	20347421	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	16885022	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of SCF ubiquitin ligase complex	IDA IDA: Inferred from direct assay	16880511	GOA
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXW11 Protein Structure

Beta-TrCP_D

F-box-like

WD40

0
100
200
300
400
500
542 a.a.

Protein Preferred Names

Protein Names

F-box/WD repeat-containing protein 11

F-box and WD repeats protein beta-TrCP2

Related Diseases

Diseases

Alias

Neurodevelopmental, Jaw, Eye, And Digital Syndrome

NEDJED

Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder

Rift Valley Fever

Rfv - [Rift Valley Fever]

Human Immunodeficiency Virus Type 1

Aids	Hiv/Aids
Aids, Delayed/Rapid Progression To	Hiv-1, Susceptibility To
Hiv-1 Viremia, Susceptibility To	Human Immunodeficiency Virus Type 1, Susceptibility To
Hiv-1	Aids, Slow Progression To
Rapid Progression To Aids From Hiv1 Infection	Hiv1 Infection, Resistance To
Hiv1 Infection	Hiv-1 Viremia
Aids, Resistance To	Aids, Rapid Progression To
Hiv/Aids, Susceptibility To	Hiv-1, Resistance To
Hiv1, Resistance To	Hiv1
Hiv-1 Disease, Delayed Progression Of	Hiv-1 Disease, Rapid Progression Of
Hiv Infection, Resistance To	Hiv Type 1, Susceptibility To
Hiv Type 1	Hiv-1 Infection
Human Immunodeficiency Virus I Infection	Acquired Immunodeficiency Syndrome
Hiv-Infection/Aids

Neuronopathy, Distal Hereditary Motor, Type Iid

HMN2D	Hmn Iid
Dhmn2d	Distal Hereditary Motor Neuronopathy Type 2d
Distal Hereditary Motor Neuropathy Type Iid	Neuronopathy, Distal Hereditary Motor, Type 2d
Neuropathy, Distal Hereditary Motor, Type Iid	Spinal Muscular Atrophy, Distal, Autosomal Dominant, Calf-Predominant
Distal Spinal Muscular Atrophy With Calf Predominance	Neuronopathy, Distal Hereditary Motor, 2d
Autosomal Dominant Spinal Muscular Atrophy Distal Calf-Predominant	Dhmn Iid
Neuropathy, Motor, Distal, Hereditary, Type 2d

Holoprosencephaly

Holoprosencephaly Sequence	Hpe
Hpe - [Holoprosencephaly]

Brachydactyly

Distal Hereditary Motor Neuronopathy Type 2

Distal Hereditary Motor Neuropathy, Type Ii	Distal Hereditary Motor Neuropathy Type 2
Distal Hereditary Motor Neuropathy Type Ii	Hmn Ii
Hmn2	Distal Hereditary Motor Neuronopathy, Type Ii
Distal Spinal Muscular Atrophy Type 2	Dhmn2
Dsma2	Neuropathy, Motor, Distal, Hereditary, Type Ii
Spinal Muscular Atrophy, Jerash Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04816	FBXW11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FBXW11	MGD	MGI:2144023
Bos taurus	FBXW11	VGNC	VGNC:28922
Felis catus	FBXW11	VGNC	VGNC:62200
Canis familiaris	FBXW11	VGNC	VGNC:40792
Rattus norvegicus	FBXW11	RGD	RGD:1309121
Macaca mulatta	FBXW11	VGNC	VGNC:72500

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