2. Gene
  3. Lat - linker for activation of T cells Gene

Lat - linker for activation of T cells Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as pp36; p36-38

Gene ID: 16797 | Gene type: protein coding

About Lat

Summary

Predicted to enable protein kinase binding activity and signaling receptor complex adaptor activity. Acts upstream of or within gene expression; inflammatory response; and lymphocyte homeostasis. Located in cell-cell junction and immunological synapse. Part of COP9 signalosome. Is expressed in liver and thymus primordium. Used to study IgG4-related disease. Human ortholog(s) of this gene implicated in immunodeficiency 52. Orthologous to human LAT (linker for activation of T cells). [provided by Alliance of Genome Resources, Apr 2022]

Lat Products(1)

mRNA Protein Name
NM_010689.3 NP_034819.1 linker for activation of T-cells family member 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21487392 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
16002666 MGI
acts upstream of or within homeostasis of number of cells IMP
IMP: Inferred from mutant phenotype
23793062 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
16002666 MGI
acts upstream of or within lymphocyte homeostasis IMP
IMP: Inferred from mutant phenotype
23776175 MGI
Cellular Component GO Annotation Evidence Reference Source
part of COP9 signalosome IDA
IDA: Inferred from direct assay
22561606 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
23793062 MGI
located in immunological synapse IDA
IDA: Inferred from direct assay
14635057 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

linker for activation of T-cells family member 1

36 kDa phospho-tyrosine adapter protein

linker protein

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-16929 Latrunculin A Inhibitor ≥98.0% Phase 4
HY-164401 QBS10072S / Phase 2
Pre-clinical Phase
Bioactive Molecules (20)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-138489 TRULI Modulator 99.98% Unkown
HY-150042 TDI-011536 Inhibitor 99.91% Unkown
HY-108540 BCH Inducer 99.13% Unkown
HY-147082 GA-017 Activator 98.95% Unkown
HY-W011391 GPNA hydrochloride 99.91% Unkown
HY-139330 MGH-CP1 Inducer 99.56% Unkown
HY-160769 NIBR-LTSi Activator 99.97% Unkown
HY-147165 VT02956 Inhibitor 99.58% Unkown
HY-120139 KMH-233 Inhibitor 98.11% Unkown
HY-N8847 α-Ionone Activator 94.30% Unkown
HY-130504 Propargyl-PEG1-acid ≥97.0% Unkown
HY-N3999 Venuloside A 99.82% Unkown
HY-120139A (R)-KMH-233 Control / Unkown
HY-127042 6,7-Epoxy-latrunculin A Inhibitor / Unkown
HY-129934S Latanoprost ethyl amide-d4 / Unkown
HY-RS07536 LAT Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS07537 LAT2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS07538 LATS1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS07539 LATS2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-147165A VT02956 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lat NCBI NCBI:27040
Canis familiaris Lat NCBI NCBI:607947
Macaca fascicularis Lat NCBI NCBI:102143768
Canis lupus familiaris Lat NCBI
Susscrofa domestica Lat NCBI
Leporidae Lat NCBI
Rattus norvegicus Lat NCBI NCBI:81511
Macaca mulatta Lat NCBI NCBI:704656