LAT - linker for activation of T cells Gene

Homo sapiens

Also known as LAT1; pp36; IMD52

Gene ID: 27040 | Gene type: protein coding

About LAT

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:28,984,803-28,990,784 (from NCBI)

This gene has 16 transcripts (splice variants), 87 orthologues and is associated with 2 phenotypes. Broad expression in lymph node (RPKM 29.3), appendix (RPKM 13.0) and 19 other tissues.

Summary

The protein encoded by this gene is phosphorylated by ZAP-70/Syk Protein Tyrosine Kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

LAT Products(4)

mRNA	Protein	Name
NM_001014987.2	NP_001014987.1	linker for activation of T-cells family member 1 isoform b
NM_001014988.2	NP_001014988.1	linker for activation of T-cells family member 1 isoform c
NM_001014989.2	NP_001014989.2	linker for activation of T-cells family member 1 isoform d
NM_014387.4	NP_055202.1	linker for activation of T-cells family member 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables molecular condensate scaffold activity	IDA IDA: Inferred from direct assay	33080222	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9489702	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	12186560	GOA
enables signaling receptor complex adaptor activity	IDA IDA: Inferred from direct assay	9489702	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Ras protein signal transduction	IMP IMP: Inferred from mutant phenotype	12646565	GOA
involved in T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	25907557	GOA
involved in calcium-mediated signaling	IMP IMP: Inferred from mutant phenotype	12646565	GOA
involved in immune response	IDA IDA: Inferred from direct assay	15100278	GOA
involved in integrin-mediated signaling pathway	IDA IDA: Inferred from direct assay	15100278	GOA
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	12646565	GOA
involved in membrane raft distribution	IDA IDA: Inferred from direct assay	33080222	GOA
involved in positive regulation of protein kinase activity	IEP IEP: Inferred from expression pattern	14624253	GOA
involved in regulation of T cell activation	IMP IMP: Inferred from mutant phenotype	12646565	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of TCR signalosome	IDA IDA: Inferred from direct assay	33080222	GOA
located in immunological synapse	IDA IDA: Inferred from direct assay	12646565	GOA
located in membrane	IDA IDA: Inferred from direct assay	12646565	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	9729044	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LAT Protein Structure

LAT

0
100
200
262 a.a.

Protein Preferred Names

Protein Names

linker for activation of T-cells family member 1

36 kDa phospho-tyrosine adapter protein

LAT Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LAT	O43561	LCK	Homo sapiens	P06239	Anti Bait CoIP	16938345
Intra	LAT	O43561	EGFR	Homo sapiens	P00533	Ub Reconstruction	31980649
Intra	LAT	O43561	EGFR	Homo sapiens	P00533	Lumier	24658140
Intra	LAT	O43561	SGTA	Homo sapiens	O43765	Validated Y2H	25416956
Intra	LAT	O43561	SGTA	Homo sapiens	O43765	Y2H Array	25416956
Intra	LAT	O43561	GRB2	Homo sapiens	P62993	Pull Down	10811803
Intra	LAT	O43561	GRB2	Homo sapiens	P62993	CoIP	10811803
Intra	LAT	O43561	GRB2	Homo sapiens	P62993	CoIP	9489702
Intra	LAT	O43561	PLCG1	Homo sapiens	P19174	Anti Bait CoIP	16938345
Intra	LAT	O43561	PLCG1	Homo sapiens	P19174	CoIP	10811803
Intra	LAT	O43561	PIK3R1	Homo sapiens	P27986	Pull Down	10811803
Intra	LAT	O43561	PIK3R1	Homo sapiens	P27986	CoIP	10811803
Intra	LAT	O43561	PTPN1	Homo sapiens	P18031	Pull Down	12857726
Intra	LAT	O43561	PTPN1	Homo sapiens	P18031	Phosphatase Assay	12857726

Cross: Cross-species interaction Intra: Intraspecies interaction

LAT Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81297	Phospho-LAT (Tyr191) Antibody (YA1021)	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P81297A	Phospho-LAT (Tyr200) Antibody (YA1022)	WB	Human
HY-P83416	LAT Antibody (YA3161)	WB, IHC-P, IP	Human

Related Diseases

Diseases

Alias

Immunodeficiency 52

Severe Combined Immunodeficiency Due To Lat Deficiency	IMD52
Scid Due To Lat Deficiency	Immunodeficiency, Type 52

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Severe Combined Immunodeficiency

Scid	Severe Combined Immunodeficiency Disease
Combined T And B Cell Inborn Immunodeficiency	Immunodeficiency, Severe Combined
Scid - [Severe Combined Immunodeficiencies]

Lymphopenia

Lymphocytopenia

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16929	Latrunculin A	Inhibitor	≥98.0%	Phase 4

Pre-clinical Phase

Bioactive Molecules (21)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-138489	TRULI	Modulator	99.98%	Unkown
HY-150042	TDI-011536	Inhibitor	99.91%	Unkown
HY-108540	BCH	Inducer	99.13%	Unkown
HY-147082	GA-017	Activator	98.95%	Unkown
HY-W011391	GPNA hydrochloride		99.91%	Unkown
HY-139330	MGH-CP1	Inducer	99.56%	Unkown
HY-160769	NIBR-LTSi	Activator	99.97%	Unkown
HY-147165	VT02956	Inhibitor	99.58%	Unkown
HY-120139	KMH-233	Inhibitor	98.11%	Unkown
HY-130504	Propargyl-PEG1-acid		≥97.0%	Unkown
HY-N8847	α-Ionone	Activator	94.30%	Unkown
HY-N3999	Venuloside A		99.82%	Unkown
HY-120139A	(R)-KMH-233		/	Unkown
HY-127042	6,7-Epoxy-latrunculin A	Inhibitor	/	Unkown
HY-129934S	Latanoprost ethyl amide-d4		/	Unkown
HY-RS07536	LAT Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07537	LAT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07538	LATS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07539	LATS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-147165A	VT02956 hydrochloride	Inhibitor	/	Unkown
HY-164401	QBS10072S		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	LAT	VGNC	VGNC:42596
Rattus norvegicus	LAT	RGD	RGD:620802
Mus musculus	LAT	MGD	MGI:1342293
Bos taurus	LAT	VGNC	VGNC:50054
Felis catus	LAT	VGNC	VGNC:63199
Macaca fascicularis	LAT	NCBI	NCBI:102143768
Canis lupus familiaris	LAT	NCBI
Susscrofa domestica	LAT	NCBI
Leporidae	LAT	NCBI
Macaca mulatta	LAT	NCBI	NCBI:704656
Others	LAT	NCBI

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