2. Gene
  3. Limk1 - LIM-domain containing, protein kinase Gene

Limk1 - LIM-domain containing, protein kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Limk; KIZ-1; LIMK-1

Gene ID: 16885 | Gene type: protein coding

About Limk1

Chromosome 5: 134,684,893-134,717,452 reverse strand.GRCm39:CM000998.3

This gene has 6 transcripts (splice variants), 262 orthologues, 23 paralogues and is associated with 11 phenotypes. Ubiquitous expression in cerebellum adult (RPKM 15.2), whole brain E14.5 (RPKM 14.2) and 27 other tissues.

Summary

This gene encodes a member of the LIM kinase family of proteins. This protein is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein also stimulates axon growth and may play a role in brain development. Homozygous knockout mice for this gene exhibit reduced bone mass, abnormal neuronal morphology and altered synaptic function. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Limk1 Products(2)

mRNA Protein Name
NM_001305875.1 NP_001292804.1 LIM domain kinase 1 isoform 2
NM_010717.3 NP_034847.1 LIM domain kinase 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
10431247 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of axon extension IGI
IGI: Inferred from genetic interaction
16204183 MGI
acts upstream of or within positive regulation of axon extension IGI
IGI: Inferred from genetic interaction
16204183 MGI
acts upstream of or within positive regulation of stress fiber assembly IGI
IGI: Inferred from genetic interaction
15199148 MGI
acts upstream of stress fiber assembly IGI
IGI: Inferred from genetic interaction
15199148 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16204183 MGI
located in focal adhesion IDA
IDA: Inferred from direct assay
15023529 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
25107909 MGI
located in male germ cell nucleus IDA
IDA: Inferred from direct assay
16399995 MGI
located in membrane IDA
IDA: Inferred from direct assay
24792215 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
16204183 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15023529 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Limk1 Protein Structure

LIM1_LIMK1

LIM1_LIMK1: cd09462 (4 - 76)

LIM2_LIMK1

LIM2_LIMK1: cd09464 (83 - 137)

PDZ

PDZ: pfam00595 (164 - 254)

STKc_LIMK1

STKc_LIMK1: cd14221 (344 - 610)

  • 0
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  • 200
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  • 500
  • 600
  • 647 a.a.
Protein Preferred Names Protein Names

LIM domain kinase 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-136848 SM1-71 Inhibitor 96.09% Unkown
HY-18305 BMS-5 Inhibitor 99.51% Unkown
HY-18304 BMS-3 Inhibitor 99.46% Unkown
HY-122630 TH-257 Inhibitor 98.36% Unkown
HY-19353 SR7826 Inhibitor 99.30% Unkown
HY-148061 DB1113 99.28% Unkown
HY-120025 CRT0105950 Inhibitor 99.91% Unkown
HY-120097 R-10015 Inhibitor 99.72% Unkown
HY-151539 TH470 Inhibitor 99.57% Unkown
HY-128062 LIMK1 inhibitor BMS-4 Inhibitor ≥99.0% Unkown
HY-14227 LIMK-IN-1 Inhibitor 99.33% Unkown
HY-N10868 8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide Inhibitor / Unkown
HY-12659B LX7101 monohydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Limk1 NCBI NCBI:3984