LIMK1 - LIM domain kinase 1 Gene

Homo sapiens

Also known as LIMK; LIMK-1

Gene ID: 3984 | Gene type: protein coding

About LIMK1

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:74,083,804-74,122,525 (from NCBI)

This gene has 8 transcripts (splice variants), 262 orthologues, 23 paralogues and is associated with 1 phenotype. Ubiquitous expression in brain (RPKM 15.7), spleen (RPKM 11.2) and 25 other tissues.

Summary

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011]

LIMK1 Products(3)

mRNA	Protein	Name
NM_016735.1
NM_002314.4	NP_002305.1	LIM domain kinase 1 isoform 1
NM_001204426.2	NP_001191355.1	LIM domain kinase 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables heat shock protein binding	IDA IDA: Inferred from direct assay	17512523	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8940095	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	22328514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	17512523	GOA
involved in positive regulation of actin filament bundle assembly	IDA IDA: Inferred from direct assay	17512523	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	17512523	GOA
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	23633677	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17512523	GOA
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	25884247	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	25884247	GOA
is active in postsynapse	IDA IDA: Inferred from direct assay	25884247	GOA
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	25884247	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LIMK1 Protein Structure

LIM

PDZ

Pkinase_Tyr

0
100
200
300
400
500
600
647 a.a.

Protein Preferred Names

Protein Names

LIM domain kinase 1

LIM motif-containing protein kinase

Related Diseases

Diseases

Alias

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Williams-Beuren Syndrome

Williams Syndrome	WBS
Wms	Deletion 7q11.23
Monosomy 7q11.23	Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb
Fanconi Schlesinger Syndrome	Beuren Syndrome
Elfin Facies Syndrome	Elfin Facies With Hypercalcemia
Hypercalcemia-Supravalvar Aortic Stenosis	Ws

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Williams-Beuren Region Duplication Syndrome

Chromosome 7q11.23 Duplication Syndrome	7q11.23 Duplication Syndrome
7q11.23 Microduplication Syndrome	Wbs Duplication Syndrome
Somerville-Van Der Aa Syndrome	Dup(7)(Q11.23)
Trisomy 7q11.23	William-Beuren Region Duplication Syndrome
Chromosome 7q11.23 Duplication

Fragile X Syndrome

FXS	Martin-Bell Syndrome
Fraxa Syndrome	Marker X Syndrome
X-Linked Mental Retardation And Macroorchidism	Fragile X Mental Retardation Syndrome
Fra Syndrome	Mental Retardation, X-Linked, Associated With Marxq28
Frax Syndrome	Symptomatic Form Of Fragile X Syndrome In Female Carriers
Fragile-X Syndrome	Fraxe Syndrome

Supravalvular Aortic Stenosis

SVAS	Supravalvar Aortic Stenosis
Supravalvar Aortic Stenosis, Eisenberg Type	Aortic Supravalvular Stenosis
Aortic Stenosis, Supravalvular	Supra-Valvular Aortic Stenosis
Stenosis, Aortic Supravalvular	Stenosis, Supravalvular Aortic
Supravalvular Stenosis, Aortic	Aortic Stenosis Supravalvular

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136848	SM1-71	Inhibitor	96.09%	Unkown
HY-18305	BMS-5	Inhibitor	99.51%	Unkown
HY-18304	BMS-3	Inhibitor	99.46%	Unkown
HY-122630	TH-257	Inhibitor	98.01%	Unkown
HY-19353	SR7826	Inhibitor	99.30%	Unkown
HY-120025	CRT0105950	Inhibitor	99.91%	Unkown
HY-120097	R-10015	Inhibitor	99.72%	Unkown
HY-148061	DB1113		99.28%	Unkown
HY-151539	TH470	Inhibitor	99.57%	Unkown
HY-128062	LIMK1 inhibitor BMS-4	Inhibitor	≥99.0%	Unkown
HY-14227	LIMK-IN-1	Inhibitor	99.33%	Unkown
HY-N10868	8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide	Inhibitor	/	Unkown
HY-12659B	LX7101 monohydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LIMK1	MGD	MGI:104572
Bos taurus	LIMK1	VGNC	VGNC:30890
Rattus norvegicus	LIMK1	RGD	RGD:62055
Canis familiaris	LIMK1	VGNC	VGNC:42681
Felis catus	LIMK1	VGNC	VGNC:68053
Macaca mulatta	LIMK1	VGNC	VGNC:74269
Others	LIMK1	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.