2. Gene
  3. Limk2 - LIM motif-containing protein kinase 2 Gene

Limk2 - LIM motif-containing protein kinase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as whe; Limk-2

Gene ID: 16886 | Gene type: protein coding

About Limk2

Chromosome 11: 3,294,256-3,359,189 reverse strand.GRCm39:CM001004.3

This gene has 13 transcripts (splice variants), 205 orthologues, 23 paralogues and is associated with 31 phenotypes. Ubiquitous expression in placenta adult (RPKM 23.2), colon adult (RPKM 19.9) and 27 other tissues.

Summary

Enables protein kinase activity. Acts upstream of or within several processes, including cornea development in camera-type eye; protein phosphorylation; and spermatogenesis. Located in cis-Golgi network and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and sensory organ. Orthologous to human LIMK2 (LIM domain kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Limk2 Products(9)

mRNA Protein Name
NM_001402862.1 NP_001389791.1 LIM domain kinase 2 isoform g
NM_001402860.1 NP_001389789.1 LIM domain kinase 2 isoform 3
NM_001402861.1 NP_001389790.1 LIM domain kinase 2 isoform f
NM_010718.4 NP_034848.1 LIM domain kinase 2 isoform a
NM_173053.2 NP_774958.1 LIM domain kinase 2 isoform b
NM_001034030.2 NP_001029202.1 LIM domain kinase 2 isoform c
NM_001402864.1 NP_001389793.1 LIM domain kinase 2 isoform c
NM_001402863.1 NP_001389792.1 LIM domain kinase 2 isoform h
NM_001361623.1 NP_001348552.1 LIM domain kinase 2 isoform d

Limk2 Protein Structure

LIM

LIM: cl02475 (11 - 64)

LIM2_LIMK2

LIM2_LIMK2: cd09465 (66 - 124)

PDZ

PDZ: pfam00595 (151 - 235)

STKc_LIMK2

STKc_LIMK2: cd14222 (336 - 607)

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  • 638 a.a.
Protein Preferred Names Protein Names

LIM domain kinase 2

LIM kinase 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-18305 BMS-5 Inhibitor 99.51% Unkown
HY-18304 BMS-3 Inhibitor 99.46% Unkown
HY-122630 TH-257 Inhibitor 98.01% Unkown
HY-148063 DB0614 98.80% Unkown
HY-19352 T56-LIMKi Inhibitor 99.07% Unkown
HY-137346 DD-03-156 99.63% Unkown
HY-120025 CRT0105950 Inhibitor 99.91% Unkown
HY-151539 TH470 Inhibitor 99.57% Unkown
HY-128062 LIMK1 inhibitor BMS-4 Inhibitor ≥99.0% Unkown
HY-14227 LIMK-IN-1 Inhibitor 99.33% Unkown
HY-12659B LX7101 monohydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Limk2 NCBI NCBI:3985