2. Gene
  3. LIMK2 - LIM domain kinase 2 Gene

LIMK2 - LIM domain kinase 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 3985 | Gene type: protein coding

About LIMK2

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:31,212,298-31,280,080 (from NCBI)

This gene has 9 transcripts (splice variants), 204 orthologues and 23 paralogues. Ubiquitous expression in skin (RPKM 19.7), placenta (RPKM 19.5) and 25 other tissues.

Summary

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin Cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

LIMK2 Products(3)

mRNA Protein Name
NM_001031801.2 NP_001026971.1 LIM domain kinase 2 isoform 1
NM_005569.4 NP_005560.1 LIM domain kinase 2 isoform 2a
NM_016733.3 NP_057952.1 LIM domain kinase 2 isoform 2b
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
22328514 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
22328514 GOA
Biological Process GO Annotation Evidence Reference Source
involved in astral microtubule organization IDA
IDA: Inferred from direct assay
22328514 GOA
involved in establishment of vesicle localization IMP
IMP: Inferred from mutant phenotype
25849865 GOA
involved in negative regulation of cilium assembly IMP
IMP: Inferred from mutant phenotype
25849865 GOA
involved in positive regulation of protein localization to nucleus IMP
IMP: Inferred from mutant phenotype
25849865 GOA
involved in positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
25849865 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
22328514 GOA
Cellular Component GO Annotation Evidence Reference Source
located in centrosome IDA
IDA: Inferred from direct assay
25849865 GOA
located in mitotic spindle IDA
IDA: Inferred from direct assay
22328514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LIMK2 Protein Structure

LIM

LIM: LIM domain (12 - 67)

LIM

LIM: LIM domain (72 - 126)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (153 - 236)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (333 - 599)

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  • 638 a.a.
Protein Preferred Names Protein Names

LIM domain kinase 2

Related Diseases

Diseases Alias
Williams-Beuren Syndrome

Williams Syndrome

WBS

Wms

Deletion 7q11.23

Monosomy 7q11.23

Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb

Fanconi Schlesinger Syndrome

Beuren Syndrome

Elfin Facies Syndrome

Elfin Facies With Hypercalcemia

Hypercalcemia-Supravalvar Aortic Stenosis

Ws
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-18305 BMS-5 Inhibitor 99.51% Unkown
HY-18304 BMS-3 Inhibitor 99.46% Unkown
HY-122630 TH-257 Inhibitor 98.01% Unkown
HY-148063 DB0614 98.80% Unkown
HY-19352 T56-LIMKi Inhibitor 99.07% Unkown
HY-137346 DD-03-156 99.63% Unkown
HY-120025 CRT0105950 Inhibitor 99.91% Unkown
HY-151539 TH470 Inhibitor 99.57% Unkown
HY-128062 LIMK1 inhibitor BMS-4 Inhibitor ≥99.0% Unkown
HY-14227 LIMK-IN-1 Inhibitor 99.33% Unkown
HY-12659B LX7101 monohydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus LIMK2 MGD MGI:1197517
Rattus norvegicus LIMK2 RGD RGD:62056
Bos taurus LIMK2 VGNC VGNC:52793
Felis catus LIMK2 VGNC VGNC:68054
Macaca mulatta LIMK2 VGNC VGNC:74270
Canis familiaris LIMK2 VGNC VGNC:52937