2. Gene
  3. Bcl2a1 - BCL2-related protein A1 Gene

Bcl2a1 - BCL2-related protein A1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Bcl2a1d

Gene ID: 170929 | Gene type: protein coding

About Bcl2a1

Primary_assembly 8: 89,716,914-89,724,998 forward strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 116 orthologues, 13 paralogues and is associated with 6 phenotypes. Biased expression in Spleen (RPKM 469.2), Thymus (RPKM 269.8) and 8 other tissues.

Summary

Enables BH domain binding activity. Involved in aging and cerebral cortex development. Predicted to be active in mitochondrial outer membrane. Orthologous to human BCL2A1 (BCL2 related protein A1). [provided by Alliance of Genome Resources, Apr 2022]

Bcl2a1 Products(1)

mRNA Protein Name
NM_133416.1 NP_596907.1 bcl-2-related protein A1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables BH domain binding IPI
IPI: Inferred from physical interaction
9356461 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
9356461 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
9813151 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bcl2a1 Protein Structure

BCL

BCL: smart00337 (36 - 139)

  • 0
  • 100
  • 175 a.a.
Protein Preferred Names Protein Names

bcl-2-related protein A1

B-cell leukemia/lymphoma 2 related protein A1

B-cell leukemia/lymphoma 2 related protein A1d

BCL2-related protein A1d

Related Agents

Clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-10969 Obatoclax Mesylate 99.74% Phase 3
HY-10969A Obatoclax / Phase 3
HY-15464A (R)-(-)-Gossypol acetic acid 98.93% Phase 2
HY-15464 (R)-(-)-Gossypol 98.82% Phase 2
Pre-clinical Phase
Bioactive Molecules (26)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-125876 PROTAC Bcl2 degrader-1 Inhibitor 99.80% Unkown
HY-132307 Mcl-1 inhibitor 6 98.40% Unkown
HY-15191B (S)-Sabutoclax Inhibitor 98.03% Unkown
HY-114310 VDR agonist 1 / Unkown
HY-135273 A-1211212 / Unkown
HY-19551 Apogossypolone / Unkown
HY-118925 Holothurin A Inhibitor / Unkown
HY-144428 Bcl-2/Mcl-1-IN-2 Inhibitor / Unkown
HY-144430 Bcl-2/Mcl-1-IN-1 Inhibitor / Unkown
HY-144431 Bcl-2/Mcl-1-IN-3 Inhibitor / Unkown
HY-147826 EGFR-IN-60 / Unkown
HY-149436 CDK2/Bcl2-IN-1 Inhibitor / Unkown
HY-156877 Bcl-2-IN-16 / Unkown
HY-159513 Bcl-2/Mcl-1-IN-4 Inhibitor / Unkown
HY-161415 BCL-xL/BCL-2 ligand 1 / Unkown
HY-169083 Bcl-2-IN-22 Inhibitor / Unkown
HY-N10481 Aviculin / Unkown
HY-N3828 epi-Eriocalyxin A / Unkown
HY-N8579 Eugenyl benzoate / Unkown
HY-RS01418 BCL2A1 Human Pre-designed siRNA Set A / Unkown
HY-RS01419 Bcl2a1 Rat Pre-designed siRNA Set A / Unkown
HY-RS01420 Bcl2a1a Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01421 BCL2L1 Human Pre-designed siRNA Set A / Unkown
HY-RS01422 Bcl2l1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01423 Bcl2l1 Rat Pre-designed siRNA Set A / Unkown
HY-123715 Anticancer agent 255 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bcl2a1 NCBI NCBI:597