BCL2A1 - BCL2 related protein A1 Gene

Homo sapiens

Also known as GRS; ACC1; ACC2; BFL1; ACC-1; ACC-2; HBPA1; BCL2L5

Gene ID: 597 | Gene type: protein coding

About BCL2A1

Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:79,960,892-79,971,196 (from NCBI)

This gene has 3 transcripts (splice variants), 116 orthologues and 8 paralogues. Biased expression in bone marrow (RPKM 133.6), appendix (RPKM 46.2) and 4 other tissues.

Summary

This gene encodes a member of the Bcl-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block Caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

BCL2A1 Products(2)

mRNA	Protein	Name
NM_004049.4	NP_004040.1	bcl-2-related protein A1 isoform 1
NM_001114735.2	NP_001108207.1	bcl-2-related protein A1 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10753914	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	34245648	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BCL2A1 Protein Structure

Bcl-2

0
100
175 a.a.

Protein Preferred Names

Protein Names

bcl-2-related protein A1

bcl-2-like protein 5	bcl2-L-5
hematopoietic BCL2-related protein A1	hemopoietic-specific early response protein
protein BFL-1

BCL2A1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BCL2A1	Q16548	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	25416956
Intra	BCL2A1	Q16548	CT45A1	Homo sapiens	Q5HYN5	Y2H Prey Pooling	32296183
Intra	BCL2A1	Q16548	CT45A1	Homo sapiens	Q5HYN5	Validated Y2H	32296183
Intra	BCL2A1	Q16548	CT45A1	Homo sapiens	Q5HYN5	Y2H Array	32296183
Intra	BCL2A1	Q16548	BAK1	Homo sapiens	Q16611	Y2H Prey Pooling	32296183
Intra	BCL2A1	Q16548	BAK1	Homo sapiens	Q16611	Validated Y2H	25416956
Intra	BCL2A1	Q16548	BAK1	Homo sapiens	Q16611	Validated Y2H	32296183
Intra	BCL2A1	Q16548	BAK1	Homo sapiens	Q16611	Y2H Array	25416956
Intra	BCL2A1	Q16548	BAK1	Homo sapiens	Q16611	Y2H Array	32296183
Intra	BCL2A1	Q16548	BAK1	Homo sapiens	Q16611	Y2H Prey Pooling	25416956
Intra	BCL2A1	Q16548	BCL2L11	Homo sapiens	O43521	Y2H Prey Pooling	32296183
Intra	BCL2A1	Q16548	BCL2L11	Homo sapiens	O43521	Y2H Array	32296183
Intra	BCL2A1	Q16548	BCL2L11	Homo sapiens	O43521	FPS	16697956
Intra	BCL2A1	Q16548	BIK	Homo sapiens	Q13323	Y2H Array	32296183
Intra	BCL2A1	Q16548	BIK	Homo sapiens	Q13323	Y2H Prey Pooling	32296183
Intra	BCL2A1	Q16548	BIK	Homo sapiens	Q13323	Y2H Array	31515488
Intra	BCL2A1	Q16548	BIK	Homo sapiens	Q13323	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BCL2A1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75590	BCL2A1 Protein, Human (His)	Q16548 (M1-S152)	≥95%

Related Diseases

Diseases

Alias

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

Post-Traumatic Stress Disorder

PTSD	Traumatic Neurosis
Post Traumatic Stress Disorder	Stress Disorders, Post-Traumatic
Posttraumatic Stress Disorder	Ptsd - [Post Traumatic Stress Disorder]
Trauma-Related Disorders

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Conn'S Syndrome

Cushing Syndrome	Hyperaldosteronism
Primary Hyperaldosteronism	Hypercortisolism
Primary Aldosteronism	Cushing'S Syndrome
Adrenal Gland Hyperfunction	Conn Syndrome
Hyperadrenalism	Ectopic Acth Syndrome
Hyperadrenocorticism	Cushing Disease
Adrenal Cortex Adenoma	Corticotroph Pituitary Adenoma
Cushing'S Disease	Pituitary Corticotroph Micro-Adenoma
Pituitary-Dependent Cushing Syndrome	Pituitary Acth Hypersecretion
Acth Syndrome, Ectopic	Acth-Secreting Pituitary Adenoma
Adrenal Hyperfunction Resulting From Pituitary Acth Excess	Ectopic Adrenocorticotropic Hormone Syndrome
Nodular Primary Adrenocortical Dysplasia	Pituitary Dependent Cushing Syndrome
Pituitary Cushing Syndrome	Pituitary-Dependant Cushing Syndrome
Pituitary-Dependant Hypercortisolism	Pituitary-Dependant Hypercortisolism Disorder
Aldosteronism Primary	Acth Syndrome Ectopic
Adrenal Cushing'S Syndrome	Adrenal Cortical Adenoma
Cushing Syndrome Nos	Cortisol Hypersecretion
Corticoadrenal Hypersecretion	Cushing Syndrome Secondary To Ectopic Acth-Secretion
Ectopic Cushing Syndrome	Hypercortisolism Due To Nonpituitary Tumour
Ectopic Acth - [Adrenocorticotropic Hormone] Secretion	Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Causing Cushing Syndrome
Idiopathic Aldosteronism	Aldosteronism
Primary Aldosteronism Due To Bilateral Adrenal Hyperplasia	Primary Aldosteronism Due To Adrenal Hyperplasia

Cortisone Reductase Deficiency 2

CORTRD2

Amelogenesis Imperfecta

Ai	Congenital Enamel Hypoplasia
Al - [Amelogenesis Imperfecta]

Myeloma, Multiple

Multiple Myeloma	Kahler Disease
Myelomatosis	Plasma Cell Myeloma
Medullary Plasmacytoma	Multiple Myeloma, Resistance To
Myeloma	Plasma Cell Dyscrasia
Multiple Myeloma, Susceptibility To	Myeloma - Multiple
Kahler'S Disease	Kahler-Bozzolo Disease
Plasma Cell Myelomas	MM
Plasma Cell Neoplasm	Primary Systemic Amyloidosis
Primary Amyloidosis	Immunoglobulin Deposition Disease
Plasmacytic Myeloma	Multiple Myelomata
Multiple Myeloma Nos	Multiple Myeloma Without Mention Of Remission
Monostotic Plasma Cell Myeloma	Mm - [Multiple Myeloma]

Gingival Recession

Localized Gingival Recession	Gingival Recession, Localized
Minimal Gingival Recession	Moderate Gingival Recession
Severe Gingival Recession	Gingival Recession, Minimal
Gingival Recession, Severe	Atrophy Of Gums
Gum Atrophy	Gingival Atrophy

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Purity	Phase
HY-10969	Obatoclax Mesylate	99.74%	Phase 3
HY-10969A	Obatoclax	/	Phase 3
HY-15464A	(R)-(-)-Gossypol acetic acid	98.93%	Phase 2
HY-15464	(R)-(-)-Gossypol	98.82%	Phase 2

Pre-clinical Phase

Bioactive Molecules (26)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125876	PROTAC Bcl2 degrader-1	Inhibitor	99.80%	Unkown
HY-132307	Mcl-1 inhibitor 6		98.40%	Unkown
HY-15191B	(S)-Sabutoclax	Inhibitor	98.03%	Unkown
HY-114310	VDR agonist 1		/	Unkown
HY-135273	A-1211212		/	Unkown
HY-19551	Apogossypolone		/	Unkown
HY-118925	Holothurin A	Inhibitor	/	Unkown
HY-144428	Bcl-2/Mcl-1-IN-2	Inhibitor	/	Unkown
HY-144430	Bcl-2/Mcl-1-IN-1	Inhibitor	/	Unkown
HY-144431	Bcl-2/Mcl-1-IN-3	Inhibitor	/	Unkown
HY-147826	EGFR-IN-60		/	Unkown
HY-149436	CDK2/Bcl2-IN-1	Inhibitor	/	Unkown
HY-156877	Bcl-2-IN-16		/	Unkown
HY-159513	Bcl-2/Mcl-1-IN-4	Inhibitor	/	Unkown
HY-161415	BCL-xL/BCL-2 ligand 1		/	Unkown
HY-169083	Bcl-2-IN-22	Inhibitor	/	Unkown
HY-N10481	Aviculin		/	Unkown
HY-N3828	epi-Eriocalyxin A		/	Unkown
HY-N8579	Eugenyl benzoate		/	Unkown
HY-RS01418	BCL2A1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS01419	Bcl2a1 Rat Pre-designed siRNA Set A		/	Unkown
HY-RS01420	Bcl2a1a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01421	BCL2L1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS01422	Bcl2l1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS01423	Bcl2l1 Rat Pre-designed siRNA Set A		/	Unkown
HY-123715	Anticancer agent 255		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BCL2A1	VGNC	VGNC:57345
Canis familiaris	BCL2A1	VGNC	VGNC:57339
Macaca mulatta	BCL2A1	VGNC	VGNC:70242
Felis catus	BCL2A1	VGNC	VGNC:69270
Rattus norvegicus	BCL2A1	RGD	RGD:620621
Others	BCL2A1	NCBI

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