SHANK2 - Shank2 SH3 and multiple ankyrin repeat domains 2 Gene

Rattus norvegicus

Also known as CortBP1; ProSAP1; Spank-3

Gene ID: 171093 | Gene type: protein coding

About SHANK2

Summary

Enables SH3 domain binding activity and protein C-terminus binding activity. A structural constituent of postsynaptic density. Involved in several processes, including adult locomotory behavior; associative learning; and social behavior. Located in several cellular components, including apical plasma membrane; cell projection membrane; and growth cone. Is active in glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic density. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human SHANK2 (SH3 and multiple ankyrin repeat domains 2). [provided by Alliance of Genome Resources, Apr 2022]

SHANK2 Products(4)

mRNA	Protein	Name
NM_001004133.1	NP_001004133.1	SH3 and multiple ankyrin repeat domains protein 2 isoform b
NM_133440.1	NP_597684.1	SH3 and multiple ankyrin repeat domains protein 2 isoform c
NM_133441.2	NP_597685.1	SH3 and multiple ankyrin repeat domains protein 2 isoform d
NM_201350.1	NP_958738.1	SH3 and multiple ankyrin repeat domains protein 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SH3 domain binding	IPI IPI: Inferred from physical interaction	15014124	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10958799	RGD
enables structural constituent of postsynaptic density	IDA IDA: Inferred from direct assay	21217644	RGD
enables structural constituent of postsynaptic density	IMP IMP: Inferred from mutant phenotype	21217644	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in adult locomotory behavior	IMP IMP: Inferred from mutant phenotype	29970986	RGD
involved in associative learning	IMP IMP: Inferred from mutant phenotype	29970986	RGD
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	21217644	RGD
involved in regulation of postsynapse organization	IMP IMP: Inferred from mutant phenotype	21217644	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	15917299	RGD
involved in response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	29970986	RGD
involved in social behavior	IMP IMP: Inferred from mutant phenotype	29970986	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	17244609	RGD
is active in asymmetric synapse	IDA IDA: Inferred from direct assay	10414979	RGD
located in brush border membrane	IDA IDA: Inferred from direct assay	15917299	RGD
located in ciliary membrane	IDA IDA: Inferred from direct assay	18596612	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	10414979	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	21217644	RGD
located in growth cone	IDA IDA: Inferred from direct assay	10958799	RGD
is active in hippocampal mossy fiber to CA3 synapse	IDA IDA: Inferred from direct assay	10414979	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	10958799	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	10414979	RGD
located in presynaptic active zone	IDA IDA: Inferred from direct assay	21119615	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

SH3 and multiple ankyrin repeat domains protein 2

GKAP/SAPAP-interacting protein	SH3 and multiple ankyrin repeat domains protein 2-like
SH3/ankyrin domain gene 2	cortactin-binding protein 1
proline-rich synapse-associated protein 1

SHANK2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Shank2	Q9QX74	CFTR	Homo sapiens	P13569	Y2H	14679199
Cross	Shank2	Q9QX74	CFTR	Homo sapiens	P13569	SPR	17244609
Intra	Shank2	Q9QX74	Plcb3	Rattus norvegicus	Q99JE6	Y2H	15632121
Intra	Shank2	Q9QX74	Plcb3	Rattus norvegicus	Q99JE6	Anti Bait CoIP	15632121
Cross	Shank2	Q9QX74	Arhgef7	Mus musculus	Q9ES28-2	Anti Tag CoIP	12626503
Intra	Shank2	Q9QX74	Pde4d	Rattus norvegicus	P14270-8	Anti Bait CoIP	17244609
Intra	Shank2	Q9QX74	Pde4d	Rattus norvegicus	P14270-8	Pull Down	17244609
Intra	Shank2	Q9QX74	Slc9a3	Rattus norvegicus	P26433	Anti Bait CoIP	20080968

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12851	SHANK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	SHANK2	NCBI	NCBI:22941

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