Slc9a3 - solute carrier family 9 member A3 Gene

Rattus norvegicus

Also known as Nhe3

Gene ID: 24784 | Gene type: protein coding

About Slc9a3

Summary

Enables sodium:proton antiporter activity. Involved in several processes, including regulation of pH; response to glucocorticoid; and sodium ion transport. Located in apical plasma membrane and brush border membrane. Used to study hypertension. Biomarker of obesity and renovascular hypertension. Human ortholog(s) of this gene implicated in congenital secretory sodium diarrhea 8. Orthologous to human SLC9A3 (solute carrier family 9 member A3). [provided by Alliance of Genome Resources, Apr 2022]

Slc9a3 Products(2)

mRNA	Protein	Name
NM_001414040.1	NP_001400969.1	sodium/hydrogen exchanger 3 precursor
NM_012654.3	NP_036786.2	sodium/hydrogen exchanger 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12576672	RGD
enables sodium:proton antiporter activity	IDA IDA: Inferred from direct assay	11880335	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	15780093	RGD
involved in receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	15113744	RGD
involved in regulation of pH	IDA IDA: Inferred from direct assay	15265811	RGD
involved in regulation of sodium ion transport	IMP IMP: Inferred from mutant phenotype	15238256	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	17095646	RGD
involved in sodium ion transport	IDA IDA: Inferred from direct assay	11880335	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	12907430	RGD
located in brush border	IDA IDA: Inferred from direct assay	11880335	RGD
located in brush border membrane	IDA IDA: Inferred from direct assay	15238256	RGD
located in recycling endosome membrane	IDA IDA: Inferred from direct assay	9442041	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sodium/hydrogen exchanger 3

NHE-3	Na(+)/H(+) exchanger 3
Solute carrier family 9 (sodium/hydrogen exchanger 3), antiporter 3, Na+/H+ (amiloride insensitive)	plasma membrane ion transport protein
solute carrier family 9 (sodium/hydrogen exchanger), member 3	solute carrier family

Slc9a3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Slc9a3	P26433	Arhgef7	Rattus norvegicus	O55043	Anti Bait CoIP	20080968
Intra	Slc9a3	P26433	Shank2	Rattus norvegicus	Q9QX74	SPR	16293618
Intra	Slc9a3	P26433	Shank2	Rattus norvegicus	Q9QX74	Y2H	16293618
Intra	Slc9a3	P26433	Chp2	Rattus norvegicus	Q810D1	IF	12576672
Intra	Slc9a3	P26433	Chp2	Rattus norvegicus	Q810D1	Far-WB	12576672
Intra	Slc9a3	P26433	Chp2	Rattus norvegicus	Q810D1	Pull Down	12576672

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13343	SLC9A3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc9a3	NCBI	NCBI:6550

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