Mc4r - melanocortin 4 receptor Gene

Mus musculus

Also known as Pkcp; Mc4-r

Gene ID: 17202 | Gene type: protein coding

About Mc4r

Chromosome 18: 66,990,775-66,993,577 reverse strand.GRCm39:CM001011.3

This gene has 1 transcript (splice variant), 231 orthologues, 18 paralogues and is associated with 44 phenotypes.

Summary

This gene encodes a member of the Melanocortin Receptor family. Melanocortin receptors are transmembrane G-protein coupled receptors, which respond to small peptide Hormones and exhibit diverse functions and tissue type localization. As part of the central nervous melanocortin system, the encoded protein is competitively bound by either melanocyte stimulating hormone or agouti-related protein to regulate energy homeostasis. Disruption of this gene promotes hyperphagia and obesity, and is associated with increased Cholesterol levels and Insulin resistance. [provided by RefSeq, Dec 2012]

Mc4r Products(1)

mRNA	Protein	Name
NM_016977.4	NP_058673.2	melanocortin receptor 4

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables melanocortin receptor activity	IDA IDA: Inferred from direct assay	9454589	MGI
enables melanocyte-stimulating hormone receptor activity	IDA IDA: Inferred from direct assay	9454589	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9454589	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within feeding behavior	IMP IMP: Inferred from mutant phenotype	12796784	MGI
acts upstream of or within insulin secretion	IGI IGI: Inferred from genetic interaction	16141392	MGI
involved in positive regulation of bone resorption	IMP IMP: Inferred from mutant phenotype	16614075	MGI
involved in regulation of eating behavior	IMP IMP: Inferred from mutant phenotype	25096581	MGI
acts upstream of or within regulation of metabolic process	IMP IMP: Inferred from mutant phenotype	12796784	MGI
acts upstream of or within response to food	IMP IMP: Inferred from mutant phenotype	26880548	MGI
acts upstream of or within response to insulin	IMP IMP: Inferred from mutant phenotype	16141392	MGI
involved in response to melanocyte-stimulating hormone	IMP IMP: Inferred from mutant phenotype	25096581	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mc4r Protein Structure

7tmA_MC4R

0
100
200
300
332 a.a.

Protein Preferred Names

Protein Names

melanocortin receptor 4

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18678A	Bremelanotide Acetate	Agonist	99.98%	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P0252	α-MSH	Agonist	99.57%	Phase 2
HY-118930	MK-0493	Agonist	99.43%	Phase 2
HY-10622	PF-00446687 free base	Agonist	98.02%	Phase 2

Pre-clinical Phase

Bioactive Molecules (20)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0227	SHU 9119		99.95%	Unkown
HY-10624	THIQ	Agonist	98.28%	Unkown
HY-P0097A	Nonapeptide-1 acetate salt	Antagonist	98.70%	Unkown
HY-P0252A	α-MSH TFA	Agonist	98.79%	Unkown
HY-P1504A	β-Melanocyte Stimulating Hormone (MSH), human TFA	Agonist	99.51%	Unkown
HY-P1215A	HS024 TFA	Antagonist	99.80%	Unkown
HY-11030A	SNT-207858 free base	Antagonist	99.66%	Unkown
HY-110123	ML-00253764 hydrochloride	Inhibitor	99.47%	Unkown
HY-P2242A	RO27-3225 TFA	Agonist	99.21%	Unkown
HY-P1478	Adrenocorticotropic Hormone (ACTH) (4-10), human	Agonist	99.23%	Unkown
HY-P1504	β-Melanocyte Stimulating Hormone (MSH), human	Agonist	98.91%	Unkown
HY-P1208	PG-931	Agonist	99.81%	Unkown
HY-P1213	JKC363	Antagonist	99.55%	Unkown
HY-P0097	Nonapeptide-1	Antagonist	99.04%	Unkown
HY-P1216A	HS014 TFA	Antagonist	99.87%	Unkown
HY-P1216	HS014	Antagonist	/	Unkown
HY-P1213A	JKC363 TFA	Antagonist	/	Unkown
HY-169731	RO27-3225 trifluoroacetate	Agonist	/	Unkown
HY-P0252B	α-MSH free acid	Agonist	/	Unkown
HY-P3561	Agouti-related Protein (AGRP) (83-132) Amide (human)	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mc4r	NCBI	NCBI:4160

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