Met - met proto-oncogene Gene

Mus musculus

Also known as HGF; HGFR; Par4; c-Met

Gene ID: 17295 | Gene type: protein coding

About Met

Chromosome 6: 17,463,799-17,573,979 forward strand.GRCm39:CM000999.3

This gene has 7 transcripts (splice variants), 207 orthologues, 53 paralogues and is associated with 62 phenotypes. Broad expression in kidney adult (RPKM 1.5), bladder adult (RPKM 6.1) and 21 other tissues.

Summary

Enables hepatocyte growth factor-activated receptor activity. Involved in cell surface receptor signaling pathway; modulation of chemical synaptic transmission; and positive chemotaxis. Acts upstream of or within several processes, including animal organ development; regulation of cellular response to stress; and regulation of cytokine production. Located in membrane. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and limb. Used to study Gilles de la Tourette syndrome; autism spectrum disorder; breast cancer; and gestational diabetes. Human ortholog(s) of this gene implicated in autistic disorder; autosomal recessive nonsyndromic deafness 97; carcinoma (multiple); and multiple myeloma. Orthologous to human MET (MET proto-oncogene, receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Met Products(4)

mRNA	Protein	Name
NM_001410124.1	NP_001397053.1	hepatocyte growth factor receptor isoform b precursor
NM_001410123.1	NP_001397052.1	hepatocyte growth factor receptor isoform a precursor
NM_008591.3	NP_032617.2	hepatocyte growth factor receptor isoform a precursor
NM_001410120.1	NP_001397049.1	hepatocyte growth factor receptor isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables hepatocyte growth factor receptor activity	IDA IDA: Inferred from direct assay	15314156	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18585357	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	7651534	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of D-glucose transmembrane transport	IMP IMP: Inferred from mutant phenotype	16049329	MGI
acts upstream of or within adult behavior	IMP IMP: Inferred from mutant phenotype	12397180	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	12397180	MGI
acts upstream of or within cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	23994610	MGI
acts upstream of or within cardiac muscle contraction	IMP IMP: Inferred from mutant phenotype	23994610	MGI
involved in chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	21490227	MGI
acts upstream of establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	16049329	MGI
involved in excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	21490227	MGI
acts upstream of or within glucose homeostasis	IMP IMP: Inferred from mutant phenotype	16049329	MGI
acts upstream of or within hepatocyte growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	15314156	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	7651534	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	21490227	MGI
acts upstream of or within muscle cell migration	IMP IMP: Inferred from mutant phenotype	7651534	MGI
acts upstream of or within muscle organ development	IGI IGI: Inferred from genetic interaction	15376315	MGI
acts upstream of or within muscle organ development	IMP IMP: Inferred from mutant phenotype	15376315	MGI
acts upstream of or within myoblast proliferation	IMP IMP: Inferred from mutant phenotype	11061428	MGI
acts upstream of or within myotube differentiation	IMP IMP: Inferred from mutant phenotype	7651534	MGI
acts upstream of or within negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23994610	MGI
acts upstream of or within negative regulation of transforming growth factor beta production	IMP IMP: Inferred from mutant phenotype	23994610	MGI
acts upstream of or within placenta development	IMP IMP: Inferred from mutant phenotype	7651534	MGI
involved in positive chemotaxis	IMP IMP: Inferred from mutant phenotype	15218527	MGI
acts upstream of or within positive regulation of D-glucose transmembrane transport	IMP IMP: Inferred from mutant phenotype	16049329	MGI
acts upstream of or within positive regulation of MAPK cascade	IPI IPI: Inferred from physical interaction	15314156	MGI
acts upstream of or within positive regulation of p38MAPK cascade	IMP IMP: Inferred from mutant phenotype	23994610	MGI
acts upstream of or within protein autophosphorylation	IDA IDA: Inferred from direct assay	15314156	MGI
acts upstream of or within reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	23994610	MGI
acts upstream of or within regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	IMP IMP: Inferred from mutant phenotype	14517989	MGI
acts upstream of or within regulation of cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	23994610	MGI
acts upstream of or within regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	21072211	MGI
involved in semaphorin-plexin signaling pathway	IMP IMP: Inferred from mutant phenotype	15218527	MGI
acts upstream of or within skeletal muscle tissue development	IMP IMP: Inferred from mutant phenotype	7651534	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	7565774	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Met Protein Structure

Sema

PSI

IPT_plexin_repeat1

IPT_plexin_repeat2

IPT

IPT_PCSR

PTKc_Met_Ron

0
300
600
900
1200
1379 a.a.

Protein Preferred Names

Protein Names

hepatocyte growth factor receptor

HGF receptor	HGF/SF receptor
SF receptor	met proto-oncogene tyrosine kinase
proto-oncogene c-Met	scatter factor receptor
tyrosine-protein kinase Met

Recombinant Met Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72940	HGFR Protein, Mouse (HEK293, Fc)	NP_032617.2 (E25-N929)	≥95%
HY-P72941	HGFR Protein, Mouse (HEK293, His)	EDL13881.1(E25-N929)	≥95%

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13016	Cabozantinib	Inhibitor	99.96%	Yes

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12035	AMG-208	Inhibitor	99.86%	Phase 2
HY-16446	SAR125844	Inhibitor	98.17%	Phase 2
HY-50683	JNJ-38877605	Inhibitor	99.95%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99455	Bafisontamab	Inhibitor	96.00%	Phase 3

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114357A	DS-1205b free base	Inhibitor	99.92%	Unkown
HY-157387	c-Met-IN-22	Inhibitor	/	Unkown
HY-123237	KRC-108	Inhibitor	/	Unkown
HY-162803	c-Met-IN-24	Inhibitor	/	Unkown
HY-161372	PARP1/c-Met-IN-1	Inhibitor	/	Unkown
HY-120908	c-Met-IN-16	Inhibitor	/	Unkown
HY-149675	VEGFR-2/c-Met-IN-2	Inhibitor	/	Unkown
HY-168135	PROTAC c-Met degrader-1	Degrader	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Met	NCBI	NCBI:4233
Canis familiaris	Met	NCBI	NCBI:403438
Macaca fascicularis	Met	NCBI	NCBI:102123512
Susscrofa domestica	Met	NCBI
Rattus norvegicus	Met	NCBI	NCBI:24553
Macaca mulatta	Met	NCBI	NCBI:704562

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