Myd88 - myeloid differentiation primary response gene 88 Gene

Mus musculus

Gene ID: 17874 | Gene type: protein coding

About Myd88

Chromosome 9: 119,165,000-119,170,477 reverse strand.GRCm39:CM001002.3

This gene has 3 transcripts (splice variants), 200 orthologues and is associated with 86 phenotypes. Ubiquitous expression in lung adult (RPKM 14.9), spleen adult (RPKM 14.1) and 28 other tissues.

Summary

Enables Toll-like Receptor binding activity and interleukin-1 receptor binding activity. Involved in several processes, including cellular response to oxidised low-density lipoprotein particle stimulus; positive regulation of cytokine production; and response to bacterium. Acts upstream of or within several processes, including positive regulation of intracellular signal transduction; regulation of cytokine production; and response to bacterium. Located in cytosol and plasma membrane. Is expressed in cerebral cortex; embryo; and telencephalon. Used to study Coronavirus infectious disease. Human ortholog(s) of this gene implicated in Waldenstroem's macroglobulinemia; colorectal carcinoma; and primary immunodeficiency disease. Orthologous to human MyD88 (MyD88 innate immune signal transduction adaptor). [provided by Alliance of Genome Resources, Apr 2022]

Myd88 Products(1)

mRNA	Protein	Name
NM_010851.3	NP_034981.1	myeloid differentiation primary response protein MyD88

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP-dependent histone chaperone activity	IMP IMP: Inferred from mutant phenotype	18319258	MGI
enables Toll-like receptor binding	IPI IPI: Inferred from physical interaction	25848864	MGI
enables interleukin-1 receptor binding	IDA IDA: Inferred from direct assay	10854325	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10854325	MGI
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	16236719	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of JNK cascade	IMP IMP: Inferred from mutant phenotype	12855817	MGI
acts upstream of or within MyD88-dependent toll-like receptor signaling pathway	IGI IGI: Inferred from genetic interaction	12719478	MGI
acts upstream of or within MyD88-dependent toll-like receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12872135	MGI
acts upstream of or within cell surface receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12719478	MGI
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	17660297	MGI
involved in cellular response to oxidised low-density lipoprotein particle stimulus	IMP IMP: Inferred from mutant phenotype	20037584	MGI
acts upstream of chemokine production	IGI IGI: Inferred from genetic interaction	12855817	MGI
involved in chromatin organization	IMP IMP: Inferred from mutant phenotype	18319258	MGI
acts upstream of or within defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	11067888	MGI
involved in defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	17635956	MGI
involved in defense response to protozoan	IMP IMP: Inferred from mutant phenotype	17660297	MGI
acts upstream of or within establishment of endothelial intestinal barrier	IMP IMP: Inferred from mutant phenotype	22155109	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	18509511	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	31164412	MGI
acts upstream of or within immunoglobulin mediated immune response	IMP IMP: Inferred from mutant phenotype	15800576	MGI
acts upstream of or within induced systemic resistance	IMP IMP: Inferred from mutant phenotype	25084278	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	18509511	MGI
involved in interleukin-1-mediated signaling pathway	IDA IDA: Inferred from direct assay	10854325	MGI
acts upstream of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	11067888	MGI
acts upstream of or within leukocyte activation involved in inflammatory response	IGI IGI: Inferred from genetic interaction	22419116	MGI
acts upstream of or within lipopolysaccharide-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	12855817	MGI
acts upstream of macrophage cytokine production	IGI IGI: Inferred from genetic interaction	12872135	MGI
acts upstream of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	10607756	MGI
acts upstream of or within microglia differentiation	IMP IMP: Inferred from mutant phenotype	18509511	MGI
acts upstream of or within neurogenesis	IMP IMP: Inferred from mutant phenotype	18509511	MGI
acts upstream of or within neutrophil activation involved in immune response	IGI IGI: Inferred from genetic interaction	22419116	MGI
acts upstream of or within neutrophil-mediated killing of bacterium	IGI IGI: Inferred from genetic interaction	22419116	MGI
involved in phagocytosis	IMP IMP: Inferred from mutant phenotype	30883606	MGI
acts upstream of or within positive regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	12855817	MGI
acts upstream of or within positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	19265123	MGI
acts upstream of or within positive regulation of NF-kappaB transcription factor activity	IGI IGI: Inferred from genetic interaction	12855817	MGI
acts upstream of or within positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	12855817	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IGI IGI: Inferred from genetic interaction	12855817	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	12855817	MGI
acts upstream of or within positive regulation of chemokine production	IGI IGI: Inferred from genetic interaction	12855817	MGI
involved in positive regulation of cytokine production involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	20037584	MGI
involved in positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	20037584	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20037584	MGI
involved in positive regulation of interleukin-17 production	IMP IMP: Inferred from mutant phenotype	18203139	MGI
involved in positive regulation of interleukin-23 production	IMP IMP: Inferred from mutant phenotype	18203139	MGI
acts upstream of or within positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	11067888	MGI
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	18203139	MGI
acts upstream of or within positive regulation of lymphocyte proliferation	IMP IMP: Inferred from mutant phenotype	10607756	MGI
acts upstream of or within positive regulation of macrophage cytokine production	IGI IGI: Inferred from genetic interaction	12872135	MGI
acts upstream of or within positive regulation of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	10607756	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	30224457	MGI
acts upstream of or within positive regulation of tumor necrosis factor production	IGI IGI: Inferred from genetic interaction	12872135	MGI
acts upstream of or within positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	10607756	MGI
acts upstream of or within regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	17615359	MGI
acts upstream of or within regulation of chemokine (C-X-C motif) ligand 1 production	IMP IMP: Inferred from mutant phenotype	25084278	MGI
acts upstream of or within regulation of chemokine (C-X-C motif) ligand 2 production	IMP IMP: Inferred from mutant phenotype	25084278	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	17475835	MGI
involved in regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	18203139	MGI
acts upstream of or within regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	25084278	MGI
acts upstream of or within regulation of neutrophil migration	IMP IMP: Inferred from mutant phenotype	25084278	MGI
acts upstream of or within regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	25084278	MGI
acts upstream of or within response to lipopolysaccharide	IGI IGI: Inferred from genetic interaction	12872135	MGI
acts upstream of or within response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	10607756	MGI
acts upstream of or within response to molecule of fungal origin	IMP IMP: Inferred from mutant phenotype	12719478	MGI
acts upstream of or within response to peptidoglycan	IMP IMP: Inferred from mutant phenotype	10607756	MGI
acts upstream of or within response to virus	IMP IMP: Inferred from mutant phenotype	14993594	MGI
involved in skin development	IMP IMP: Inferred from mutant phenotype	31164412	MGI
acts upstream of tumor necrosis factor production	IGI IGI: Inferred from genetic interaction	12872135	MGI
acts upstream of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	10607756	MGI
acts upstream of or within type I interferon production	IMP IMP: Inferred from mutant phenotype	15800576	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	16751103	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16751103	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Myd88 Protein Structure

Death_MyD88

TIR

0
100
200
296 a.a.

Protein Preferred Names

Protein Names

myeloid differentiation primary response protein MyD88

myeloid differentiation primary response protein 88

Related Agents

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112137	Trehalose-6,6'-dibehenate		≥98.0%	Phase 3
HY-135317	Emavusertib	Inhibitor	99.96%	Phase 2
HY-135317B	Emavusertib hydrochloride	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (27)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139397	TJ-M2010-5	Inhibitor	99.85%	Unkown
HY-50937	ST 2825	Inhibitor	99.92%	Unkown
HY-110204	Heclin		98.21%	Unkown
HY-N0703	Schaftoside	Inhibitor	99.67%	Unkown
HY-19744	T6167923	Inhibitor	99.40%	Unkown
HY-149992	MyD88-IN-1	Inhibitor	99.95%	Unkown
HY-110195	Smurf1-IN-A01		99.81%	Unkown
HY-18976	UF010		99.84%	Unkown
HY-Y0278	Chloranil	Inducer	98%	Unkown
HY-W011400	TLR1		99.43%	Unkown
HY-W014223	2,4′-Dihydroxybenzophenone	Inhibitor	98.00%	Unkown
HY-P10719A	Pepinh-MYD TFA	Inhibitor	/	Unkown
HY-P10719	Pepinh-MYD	Inhibitor	/	Unkown
HY-W097625	6-Methoxyflavone	Inhibitor	99.87%	Unkown
HY-RS08886	MYD88 Human Pre-designed siRNA Set A	Inhibitor	/	Unkown
HY-RS08887	Myd88 Mouse Pre-designed siRNA Set A	Inhibitor	/	Unkown
HY-173063	TLR8 antagonist-1	Inhibitor	/	Unkown
HY-RS08888	Myd88 Rat Pre-designed siRNA Set A	Inhibitor	/	Unkown
HY-P10178	Myristoylated ARF6 (2-13)	Inhibitor	/	Unkown
HY-170446	MyD88-IN-2	Inhibitor	/	Unkown
HY-N3979	Grossamide	Inhibitor	/	Unkown
HY-163775	Anti-inflammatory agent 88	Agonist	/	Unkown
HY-Y0278R	Chloranil (Standard)	Inducer	/	Unkown
HY-135317E	Emavusertib maleate	Inhibitor	/	Unkown
HY-135317C	Emavusertib tosylate	Inhibitor	/	Unkown
HY-135317D	Emavusertib mesylate	Inhibitor	/	Unkown
HY-135317F	Emavusertib phosphate	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Myd88	NCBI	NCBI:4615

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