6-Methoxyflavone

Cat. No.: HY-W097625 Purity: 99.87%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

6-Methoxyflavone is a methoxyflavone that can be isolated from Pimelea simplex F. Muell. and P. decora Domin.. 6-Methoxyflavone exhibits anti-inflammatory effects and neuropathic pain relieving properties in chemotherapy-induced peripheral neuropathy (CIPN). 6-Methoxyflavone can be used in the research of nephritis.

For research use only. We do not sell to patients.

6-Methoxyflavone Chemical Structure

CAS No. : 26964-24-9

Size	Stock	Quantity
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All NF-κB Isoform Specific Products:

View All Isoforms

NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

View All p38 MAPK Isoform Specific Products:

View All Isoforms

p38 MAPK p38α p38β MAPK13 p38δ p38γ

View All Toll-like Receptor (TLR) Isoform Specific Products:

View All Isoforms

TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A2780 ADR	IC₅₀	13 μM Compound: 8	Inhibition of P-gp expressed in A2780adr cells by calcein AM accumulation assay Inhibition of P-gp expressed in A2780adr cells by calcein AM accumulation assay	[PMID: 21354800]
MCF7	IC₅₀	10 μM Compound: 8	Inhibition of BCRP expressed in MCF-7 MX cells using Hoechst 33342 staining Inhibition of BCRP expressed in MCF-7 MX cells using Hoechst 33342 staining	[PMID: 21354800]
MDCK	IC₅₀	15 μM Compound: 8	Inhibition of MDR1 expressed in MDCK cells using rhodamine 123 staining by flow cytometry Inhibition of MDR1 expressed in MDCK cells using rhodamine 123 staining by flow cytometry	[PMID: 21354800]
MDCK	IC₅₀	3.4 μM Compound: 8	Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining	[PMID: 21354800]

Molecular Weight

252.27

Formula

C₁₆H₁₂O₃

CAS No.

26964-24-9

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C=C(C2=CC=CC=C2)OC3=CC=C(OC)C=C13

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 5 mg/mL (19.82 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.9640 mL	19.8201 mL	39.6402 mL
5 mM	0.7928 mL	3.9640 mL	7.9280 mL
10 mM	0.3964 mL	1.9820 mL	3.9640 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.87%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (248 KB) HNMR (118 KB) RP-HPLC (235 KB)

Handling Instructions (2659 KB)

References

[1]. Freeman P W, et al. The constituents of Australian Pimelea species. II. The isolation of unusual flavones from P. simplex and P. decora[J]. Australian journal of chemistry, 1981, 34(8): 1779-1784.

[2]. Shahid M, Subhan F, Ahmad N, et al. The flavonoid 6-methoxyflavone allays cisplatin-induced neuropathic allodynia and hypoalgesia[J]. Biomedicine & pharmacotherapy, 2017, 95: 1725-1733. [Content Brief]

[3]. Wang X, et al. 6-Hydroxyflavone and derivatives exhibit potent anti-inflammatory activity among mono-, di-and polyhydroxylated flavones in kidney mesangial cells[J]. PLoS One, 2015, 10(3): e0116409. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.9640 mL	19.8201 mL	39.6402 mL	99.1006 mL
	5 mM	0.7928 mL	3.9640 mL	7.9280 mL	19.8201 mL
	10 mM	0.3964 mL	1.9820 mL	3.9640 mL	9.9101 mL
	15 mM	0.2643 mL	1.3213 mL	2.6427 mL	6.6067 mL